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VDR [nucleoplasm]
Stable Identifier
R-HSA-375512
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NR1I1, VDR_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Nuclear Receptor transcription pathway (Homo sapiens)
Formation of NR-MED1 Coactivator Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
NR-MED1 Coactivator Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
Formation of NR-NCOR Corepressor Complex (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
NR-NCOR CoRepressor Complex [nucleoplasm] (Homo sapiens)
NR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Vitamin D (calciferol) metabolism (Homo sapiens)
1,25(OH)2D binds VDR (Homo sapiens)
1,25(OH)2D:VDR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
VDR agonists bind VDR (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
VDR:VDR agonists [nucleoplasm] (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11473 VDR
Gene Names
VDR, NR1I1
Chain
chain:1-427
Reference Genes
BioGPS Gene:7421 VDR
COSMIC (genes):VDR VDR
CTD Gene:7421 VDR
dbSNP Gene:7421 VDR
ENSEMBL:ENSG00000111424 VDR
HGNC:12679 VDR
KEGG:hsa:7421 VDR
Monarch:7421 VDR
NCBI Gene:7421 VDR
OMIM:601769 VDR
UCSC:P11473 VDR
Reference Transcript
RefSeq:XM_006719587.3 VDR
RefSeq:XM_011538720.2 VDR
RefSeq:NM_000376.2 VDR
RefSeq:NM_001017535.1 VDR
RefSeq:NM_001017536.1 VDR
Other Identifiers
11728776_s_at
11728777_a_at
11750983_a_at
11758546_x_at
1388_g_at
1410_at
16763764
204253_PM_s_at
204253_s_at
204254_PM_s_at
204254_s_at
204255_PM_s_at
204255_s_at
3452817
3452819
3452820
3452821
3452822
3452824
3452825
3452826
3452827
3452831
3452833
3452835
3452842
3452848
3452849
57460_at
7421
7962689
A_23_P162589
GE57479
GO:0000122
GO:0000785
GO:0000902
GO:0000978
GO:0000981
GO:0001501
GO:0003677
GO:0003700
GO:0004879
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006816
GO:0006874
GO:0007595
GO:0008270
GO:0008285
GO:0008289
GO:0009887
GO:0010628
GO:0010839
GO:0010980
GO:0012501
GO:0016071
GO:0022414
GO:0022600
GO:0030154
GO:0030501
GO:0030522
GO:0035435
GO:0038185
GO:0038186
GO:0042789
GO:0043226
GO:0043235
GO:0043565
GO:0045618
GO:0045892
GO:0045944
GO:0046697
GO:0046872
GO:0046965
GO:0048384
GO:0048856
GO:0050892
GO:0055085
GO:0060057
GO:0060058
GO:0060089
GO:0060558
GO:0060745
GO:0070561
GO:0070564
GO:0070644
GO:0090575
GO:0140110
GO:1902098
GO:1902121
GO:1903412
HMNXSV003010726
HMNXSV003043975
Hs.2062.0.A2_3p_a_at
Hs.2062.0.A3_3p_a_at
ILMN_1666203
ILMN_1869034
ILMN_2319952
J03258_at
PH_hs_0000277
TC12001439.hg
TC12002858.hg
g4507882_3p_a_at
Participates
as a member of
NR [nucleoplasm] (Homo sapiens)
as an input of
PIAS4 SUMOylates VDR with SUMO2 (Homo sapiens)
VDR agonists bind VDR (Homo sapiens)
1,25(OH)2D binds VDR (Homo sapiens)
as a component of
VDR:VDR agonists [nucleoplasm] (Homo sapiens)
1,25(OH)2D:VDR [nucleoplasm] (Homo sapiens)
Other forms of this molecule
polySUMO2-VDR [nucleoplasm]
Inferred To
nhr-8 [nucleoplasm]
(Caenorhabditis elegans)
vdr [nucleoplasm]
(Xenopus tropicalis)
daf-12 [nucleoplasm]
(Caenorhabditis elegans)
nhr-48 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of VDR [nucleoplasm]
(Caenorhabditis elegans)
VDR [nucleoplasm]
(Bos taurus)
VDR [nucleoplasm]
(Canis familiaris)
VDR [nucleoplasm]
(Danio rerio)
VDR [nucleoplasm]
(Gallus gallus)
VDR [nucleoplasm]
(Mus musculus)
VDR [nucleoplasm]
(Rattus norvegicus)
VDR [nucleoplasm]
(Sus scrofa)
Hr96 [nucleoplasm]
(Drosophila melanogaster)
Cross References
ZINC - World Drugs
VDR_HUMAN
Guide to Pharmacology - Targets
605
OpenTargets
ENSG00000111424
ENSEMBL
ENSP00000447173
,
ENST00000550325
,
ENST00000395324
,
ENSP00000378734
,
ENSP00000449573
,
ENST00000549336
ZINC - FDA approved
VDR_HUMAN
ZINC - Substances
VDR_HUMAN
ZINC - Biogenic
VDR_HUMAN
ZINC target
P11473
PRO
P11473
GlyGen
P11473
PDB
3CS6
,
3X31
,
4G2I
,
1DB1
,
3WWR
,
3B0T
,
4ITF
,
1IE8
,
3A78
,
3A2J
,
1TXI
,
3W0C
,
1KB6
,
1S19
,
1S0Z
,
3M7R
,
8IQN
,
2HB8
,
2HAS
,
3TKC
,
3OGT
,
5GT4
,
3AUQ
,
3AZ1
,
2HAM
,
3W0Y
,
5YSY
,
3CS4
,
3X36
,
5YT2
,
3P8X
,
3AX8
,
1IE9
,
3VHW
,
3A2I
,
4ITE
,
7QPP
,
8IQT
,
1KB4
,
3WGP
,
1KB2
,
5V39
,
3A3Z
,
3AZ3
,
2HB7
,
3W0A
,
3AUR
,
1YNW
,
3AZ2
,
3A40
,
3KPZ
,
2HAR
ZINC - Investigational
VDR_HUMAN
ZINC - Metabolites
VDR_HUMAN
HPA
ENSG00000111424-VDR
Pharos - Targets
P11473
Orphanet
VDR
ZINC - Predictions - Purchasable
VDR_HUMAN
HMDB Protein
HMDBP01798
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19793 RXRA
4
RXRA [nucleoplasm]
(R-HSA-381319)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
0.791
6
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.743
4
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.667
5
UniProt:Q15788 NCOA1
3
NCOA1 [nucleoplasm]
(R-HSA-442496)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
0.656
3
UniProt:Q13501 SQSTM1
7
SQSTM1 [cytosol]
(R-HSA-193937)
SQSTM1 [nucleoplasm]
(R-HSA-210961)
ub K420 p-S349 SQSTM1 [cytosol]
(R-HSA-9766536)
p-S349 SQSTM1 [cytosol]
(R-HSA-9766524)
K7 ub-SQSTM1 [cytosol]
(R-HSA-9759088)
SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711954)
SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9711967)
0.591
4
UniProt:P28700 Rxra
5
RXRA [cytosol]
(R-MMU-9619757)
phospho-p-S21-RXRA [nucleoplasm]
(R-MMU-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-MMU-4341130)
Rxra [nucleoplasm]
(R-MMU-442483)
RXRA [nucleoplasm]
(R-MMU-381319)
0.576
3
UniProt:Q15645 PCH2
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.547
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.537
6
UniProt:Q15596 NCOA2
3
NCOA2 [nucleoplasm]
(R-HSA-376398)
NCOA2 (869-1464) [nucleoplasm]
(R-HSA-5603186)
monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm]
(R-HSA-4085305)
0.524
2
UniProt:P26045 PTPN3
3
PTPN3 [cytosol]
(R-HSA-8867650)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [plasma membrane]
(R-HSA-5490317)
0.524
4
IntAct:EBI-9915211 CO1A1
0.524
2
UniProt:Q9JLI4 NCOA6
0.508
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.499
2
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