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EIF2S3 [cytosol]
Stable Identifier
R-HSA-72514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2-gamma, eIF-2-gamma, eukaryotic translation initiation factor 2 gamma subunit, eukaryotic translation initiation factor 2, subunit 3, Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 gamma subunit
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Translation of ATF5 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Translation of PPP1R15A (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha) (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Translation of DDIT3 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
De novo formation of eIF2:GTP (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Met-tRNAi binds to eIF2:GTP to form the ternary complex (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
ternary complex [cytosol] (Homo sapiens)
eIF2:GTP [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
PERK regulates gene expression (Homo sapiens)
EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Translation of ATF4 (Homo sapiens)
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
ABCF1 binds EIF2 (Homo sapiens)
ABCF1:EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
EIF2S1:EIF2S2:EIF2S3 [cytosol] (Homo sapiens)
EIF2S3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41091 EIF2S3
Gene Names
EIF2S3, EIF2G
Chain
initiator methionine:1, chain:2-472
Reference Genes
BioGPS Gene:1968 EIF2S3
COSMIC (genes):EIF2S3 EIF2S3
CTD Gene:1968 EIF2S3
dbSNP Gene:1968 EIF2S3
ENSEMBL:ENSG00000130741 EIF2S3
HGNC:3267 EIF2S3
KEGG Gene (Homo sapiens):1968 EIF2S3
Monarch:1968 EIF2S3
NCBI Gene:1968 EIF2S3
OMIM:300161 EIF2S3
UCSC:P41091 EIF2S3
Reference Transcript
RefSeq:NM_001415.3 EIF2S3
Other Identifiers
0002470142
11719066_a_at
11719067_s_at
11757858_s_at
11757910_x_at
1272_at
1968
205321_at
224935_at
224936_at
3404722
35934_at
3971879
3971880
3971882
3971883
3971885
3971887
3971888
3971889
3971890
3971891
3971892
3971893
3971899
3971900
3971901
3971902
3971903
44646_r_at
8166493
A_23_P137031
GE80077
GO:0000166
GO:0001731
GO:0003674
GO:0003723
GO:0003743
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005850
GO:0006412
GO:0006413
GO:0006810
GO:0008135
GO:0008150
GO:0009058
GO:0016787
GO:0022607
GO:0022618
GO:0032991
GO:0034641
GO:0043167
GO:0043226
GO:0045296
GO:0045903
GO:0055085
GO:0065003
GO:0070062
Hs.30376.1.A1_3p_at
Hs.30376.1.A2_3p_at
ILMN_1665717
L19161_at
PH_hs_0030533
TC0X000114.hg
TC0X001625.hg
g4503506_3p_at
Participant Of
hasComponent
EIF2S1:EIF2S2:EIF2S3 [cytosol]
p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]
Inferred To
eif2s3 [cytosol] (Danio rerio)
eif2s3 [cytosol] (Dictyostelium discoideum)
eIF2gamma [cytosol] (Drosophila melanogaster)
tif213 [cytosol] (Schizosaccharomyces pombe)
GCD11 [cytosol] (Saccharomyces cerevisiae)
Eif2s3 [cytosol] (Rattus norvegicus)
LOC100624149 [cytosol] (Sus scrofa)
EIF2S3 [cytosol] (Bos taurus)
EIF2S3 [cytosol] (Canis familiaris)
EIF2S3 [cytosol] (Gallus gallus)
EIF2S3 [cytosol] (Plasmodium falciparum)
EIF2S3 [cytosol] (Xenopus tropicalis)
Eif2s3x [cytosol] (Mus musculus)
eif-2gamma [cytosol] (Caenorhabditis elegans)
Cross References
RefSeq
NP_001406.1
OpenTargets
ENSG00000130741
IntEnz
3.6.5.3
HPA
ENSG00000130741-EIF2S3
GeneCards
P41091
Ensembl
ENSP00000253039
,
ENST00000253039
,
ENSG00000130741
PRO
P41091
Orphanet
24504
HMDB Protein
HMDBP08451
PDB
6FEC
,
6K72
,
6O85
,
6K71
,
6O81
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15534 PER1
4
p-S-PER1 [nucleoplasm]
(R-HSA-3325590)
p-S-PER1 [cytosol]
(R-HSA-400310)
PER1 [cytosol]
(R-HSA-400373)
Ub-p-S-PER1 [cytosol]
(R-HSA-517831)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:P38936 CDKN1A
5
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
CDKN1A [cytosol]
(R-HSA-182512)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
0.556
3
UniProt:Q06547-2 GABPB1
1
NRF2 beta-2 subunit [nucleoplasm]
(R-HSA-1592200)
0.556
3
UniProt:Q06547-3 GABPB1
1
NRF2 gamma-1 subunit [nucleoplasm]
(R-HSA-1592216)
0.556
3
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