Reactome | EIF2S3 [cytosol]

EIF2S3 [cytosol]

Stable Identifier

R-HSA-72514

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF2-gamma, eIF-2-gamma, eukaryotic translation initiation factor 2 gamma subunit, eukaryotic translation initiation factor 2, subunit 3, Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 gamma subunit

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External Reference Information

External Reference

UniProt:P41091 EIF2S3

Gene Names

EIF2S3, EIF2G

Chain

initiator methionine:, chain:2-472

Reference Genes

BioGPS Gene:1968 EIF2S3

COSMIC (genes):EIF2S3 EIF2S3

CTD Gene:1968 EIF2S3

dbSNP Gene:1968 EIF2S3

ENSEMBL:ENSG00000130741 EIF2S3

ENSEMBL_homo_sapiens_GENE:ENSG00000130741.11 EIF2S3

HGNC:3267 EIF2S3

KEGG Gene (Homo sapiens):1968 EIF2S3

Monarch:1968 EIF2S3

NCBI Gene:1968 EIF2S3

OMIM:300161 EIF2S3

UCSC:P41091 EIF2S3

Reference Transcript

RefSeq:NM_001415.3 EIF2S3

Other Identifiers

11719066_a_at

11719067_s_at

11757858_s_at

11757910_x_at

1272_at

1968

205321_PM_at

205321_at

224935_PM_at

224935_at

224936_PM_at

224936_at

3404722

35934_at

3971879

3971880

3971882

3971883

3971885

3971887

3971888

3971889

3971890

3971891

3971892

3971893

3971899

3971900

3971901

3971902

3971903

44646_r_at

8166493

A_23_P137031

GE80077

GO:0000049

GO:0000166

GO:0001731

GO:0002181

GO:0003723

GO:0003743

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005850

GO:0006412

GO:0006413

GO:0008135

GO:0016787

GO:0043226

GO:0045182

GO:0045296

GO:0065003

GO:0070062

HMNXSV003012359

Hs.30376.1.A1_3p_at

Hs.30376.1.A2_3p_at

ILMN_1665717

L19161_at

PH_hs_0030533

TC0X000114.hg

TC0X001625.hg

g4503506_3p_at

Participates

as a component of

Inferred To

eif2s3 [cytosol] (Xenopus tropicalis)

EIF2S3B [cytosol] (Sus scrofa)

EIF2S3 [cytosol] (Bos taurus)

EIF2S3 [cytosol] (Canis familiaris)

EIF2S3 [cytosol] (Danio rerio)

EIF2S3 [cytosol] (Dictyostelium discoideum)

EIF2S3 [cytosol] (Drosophila melanogaster)

EIF2S3 [cytosol] (Gallus gallus)

EIF2S3 [cytosol] (Plasmodium falciparum)

EIF2S3 [cytosol] (Rattus norvegicus)

EIF2S3 [cytosol] (Saccharomyces cerevisiae)

EIF2S3 [cytosol] (Schizosaccharomyces pombe)

Eif2s3x [cytosol] (Mus musculus)

eif-2gamma [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001406.1

OpenTargets

ENSG00000130741

IntEnz

3.6.5.3

GeneCards

P41091

HPA

ENSG00000130741-EIF2S3

Ensembl

ENSP00000253039, ENSG00000130741, ENST00000253039

PRO

P41091

Pharos - Targets

P41091

Orphanet

24504

HMDB Protein

HMDBP08451

PDB

6O85, 6K71, 6ZP4, 6ZMW, 6YBV, 7D43, 6K72, 8PHV, 6O81, 8PHD, 7QP6, 7A09, 7F66, 7F67, 6FEC, 7QP7

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6

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