Reactome | EIF2S3 [cytosol]

EIF2S3 [cytosol]

Stable Identifier

R-HSA-72514

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF2-gamma, eIF-2-gamma, eukaryotic translation initiation factor 2 gamma subunit, eukaryotic translation initiation factor 2, subunit 3, Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 gamma subunit

Icon

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P41091 EIF2S3

Gene Names

EIF2S3, EIF2G

Chain

initiator methionine:, chain:2-472

Reference Genes

BioGPS Gene:1968 EIF2S3

COSMIC (genes):EIF2S3 EIF2S3

CTD Gene:1968 EIF2S3

dbSNP Gene:1968 EIF2S3

ENSEMBL:ENSG00000130741 EIF2S3

HGNC:3267 EIF2S3

KEGG:hsa:1968 EIF2S3

Monarch:1968 EIF2S3

NCBI Gene:1968 EIF2S3

OMIM:300161 EIF2S3

UCSC:P41091 EIF2S3

Reference Transcript

RefSeq:NM_001415.3 EIF2S3

Other Identifiers

11719066_a_at

11719067_s_at

11757858_s_at

11757910_x_at

1272_at

17102162

1968

205321_PM_at

205321_at

224935_PM_at

224935_at

224936_PM_at

224936_at

3404722

35934_at

3971878

3971879

3971880

3971882

3971883

3971885

3971886

3971887

3971888

3971889

3971890

3971891

3971892

3971893

3971894

3971895

3971899

3971900

3971901

3971902

3971903

44646_r_at

8166493

A_23_P137031

GE61645

GE80077

GO:0000049

GO:0001731

GO:0002183

GO:0003723

GO:0003743

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005737

GO:0005829

GO:0005850

GO:0006412

GO:0006413

GO:0008135

GO:0016787

GO:0043226

GO:0045182

GO:0045296

GO:0065003

GO:0070062

GO:1990856

HMNXSV003012359

HMNXSV003018795

Hs.30376.1.A1_3p_at

Hs.30376.1.A2_3p_at

ILMN_1665717

L19161_at

PH_hs_0030533

TC0X000114.hg

TC0X001625.hg

g4503506_3p_at

p17151

Participates

as a component of

Inferred To

eif2s3 [cytosol] (Xenopus tropicalis)

EIF2S3B [cytosol] (Sus scrofa)

EIF2S3 [cytosol] (Bos taurus)

EIF2S3 [cytosol] (Canis familiaris)

EIF2S3 [cytosol] (Danio rerio)

EIF2S3 [cytosol] (Dictyostelium discoideum)

EIF2S3 [cytosol] (Drosophila melanogaster)

EIF2S3 [cytosol] (Gallus gallus)

EIF2S3 [cytosol] (Plasmodium falciparum)

EIF2S3 [cytosol] (Rattus norvegicus)

EIF2S3 [cytosol] (Saccharomyces cerevisiae)

EIF2S3 [cytosol] (Schizosaccharomyces pombe)

Eif2s3x [cytosol] (Mus musculus)

eif-2gamma [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001406.1

OpenTargets

ENSG00000130741

ENSEMBL

ENSP00000253039, ENST00000253039

IntEnz

3.6.5.3

HPA

ENSG00000130741-EIF2S3

PRO

P41091

Pharos - Targets

P41091

Orphanet

EIF2S3

GlyGen

P41091

PDB

6K71, 8PPL, 8OZ0, 7F66, 8QZZ, 6YBV, 6ZMW, 6FEC, 8PHD, 6O85, 7QP7, 6K72, 6ZP4, 7F67, 6O81, 7A09, 8PHV, 7D43, 7QP6

HMDB Protein

HMDBP08451

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6

Cite Us!