Reactome | IGF1R(31-736) [plasma membrane]

IGF1R(31-736) [plasma membrane]

Stable Identifier

R-HSA-2404169

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

IGF1R, IGF1R alpha peptide, Insulin-like growth factor 1 receptor ecNumber2.7.10.1/ecNumber, IGF1R_HUMAN

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External Reference Information

External Reference

UniProt:P08069 IGF1R

Gene Names

IGF1R

Chain

signal peptide:1-30, chain:31-736, chain:741-1367

Reference Genes

BioGPS Gene:3480 IGF1R

COSMIC (genes):IGF1R IGF1R

CTD Gene:3480 IGF1R

dbSNP Gene:3480 IGF1R

ENSEMBL:ENSG00000140443 IGF1R

ENSEMBL_homo_sapiens_GENE:ENSG00000140443.15 IGF1R

HGNC:5465 IGF1R

KEGG Gene (Homo sapiens):3480 IGF1R

Monarch:3480 IGF1R

NCBI Gene:3480 IGF1R

OMIM:147370 IGF1R

UCSC:P08069 IGF1R

Reference Transcript

Other Identifiers

11718704_at

11718705_at

11718706_s_at

11718707_a_at

11752328_a_at

11757745_s_at

1335_at

16805495

203627_PM_at

203627_at

203628_PM_at

203628_at

225330_PM_at

225330_at

243358_PM_at

243358_at

34718_at

3480

3610799

3610801

3610803

3610805

3610806

3610814

3610841

3610842

3610846

3610854

3610856

3610857

3610861

3610862

3610866

3610868

3610871

3610872

3610873

3610875

3610879

3610880

3610882

3610885

3610886

3610887

3610888

3610900

3610901

3610902

3610903

3610904

3610959

3610960

3610961

3610962

3610963

3610964

3610965

3610966

3610967

3610968

3610969

60450_at

64083_at

64981_at

7986359

7986383

A_14_P120932

A_23_P205986

A_23_P417282

GE80962

GO:0000166

GO:0000910

GO:0001965

GO:0002376

GO:0003230

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005009

GO:0005010

GO:0005158

GO:0005215

GO:0005515

GO:0005520

GO:0005524

GO:0005886

GO:0005899

GO:0005901

GO:0006468

GO:0006629

GO:0006955

GO:0007163

GO:0007165

GO:0007169

GO:0007409

GO:0008284

GO:0008286

GO:0009725

GO:0010656

GO:0012501

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0021549

GO:0021766

GO:0022414

GO:0023052

GO:0030010

GO:0030154

GO:0030315

GO:0030335

GO:0030424

GO:0031175

GO:0031667

GO:0031994

GO:0032467

GO:0032868

GO:0032869

GO:0033197

GO:0033690

GO:0034224

GO:0034330

GO:0035094

GO:0035867

GO:0036211

GO:0038083

GO:0042802

GO:0043025

GO:0043066

GO:0043226

GO:0043231

GO:0043235

GO:0043243

GO:0043279

GO:0043409

GO:0043410

GO:0043491

GO:0043548

GO:0043559

GO:0043560

GO:0044849

GO:0044877

GO:0045056

GO:0045471

GO:0046328

GO:0046777

GO:0048009

GO:0048661

GO:0048680

GO:0048856

GO:0048870

GO:0051054

GO:0051897

GO:0060089

GO:0071260

GO:0071333

GO:0071392

GO:0071393

GO:0071394

GO:0071549

GO:0071560

GO:0090031

GO:0090398

GO:0097062

GO:0097242

GO:0120162

GO:0140096

GO:0140318

GO:1902065

GO:1902911

GO:1903944

GO:1904045

GO:1904193

GO:1904385

GO:1904646

GO:1990314

HMNXSV003003826

HMNXSV003052249

Hs.104679.0.S1_3p_at

Hs.239176.0.S2_3p_at

Hs.239176.0.S3_3p_at

Hs.293960.0.A1_3p_at

ILMN_1675048

ILMN_1744023

PH_hs_0012894

TC15000949.hg

X04434_at

Participates

as a component of

Other forms of this molecule

IGF1R(741-1367) [plasma membrane]

p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]

Inferred To

IGF1R(31-736) [plasma membrane] (Bos taurus)

IGF1R(31-736) [plasma membrane] (Canis familiaris)

IGF1R(31-736) [plasma membrane] (Drosophila melanogaster)

IGF1R(31-736) [plasma membrane] (Gallus gallus)

IGF1R(31-736) [plasma membrane] (Mus musculus)

IGF1R(31-736) [plasma membrane] (Rattus norvegicus)

IGF1R(31-736) [plasma membrane] (Sus scrofa)

IGF1R(31-736) [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001278787.1, NP_000866.1

ZINC - World Drugs

IGF1R_HUMAN

Guide to Pharmacology - Targets

1801

OpenTargets

ENSG00000140443

ZINC - FDA approved

IGF1R_HUMAN

ZINC - Substances

IGF1R_HUMAN

ZINC - Biogenic

IGF1R_HUMAN

ZINC target

P08069

PRO

P08069

PDB

6VWG, 8TAN, 7V3P, 3QQU, 1M7N, 8PYJ, 3NW5, 6VWH, 4D2R, 7XLC, 8PYI, 3NW6, 3LW0, 1K3A, 6JK8, 3LVP, 1P4O, 7U23, 3D94, 5U8R, 8PYN, 3F5P, 5HZN, 5FXS, 1IGR, 2OJ9, 8PYM, 3I81, 7XGD, 4XSS, 5FXQ, 3NW7, 7S8V, 8PYL, 6VWI, 2ZM3, 1JQH, 7S0Q, 5U8Q, 5FXR, 8PYK, 6VWJ, 3O23, 7YRR, 7PH8

ZINC - Investigational

IGF1R_HUMAN

ZINC - Metabolites

IGF1R_HUMAN

HPA

ENSG00000140443-IGF1R

GeneCards

P08069

Ensembl

ENSG00000140443, ENST00000650285, ENSP00000497069

Pharos - Targets

P08069

Orphanet

16817

ZINC - Predictions - Purchasable

IGF1R_HUMAN

HMDB Protein

HMDBP01188

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.832	7
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.803	6
UniProt:P05019 IGF1	2	IGF1 [platelet alpha granule lumen] (R-HSA-139878) IGF1 [extracellular region] (R-HSA-2404178)	0.783	8
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.772	5
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.688	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.669	6
UniProt:Q9NZN5 ARHGEF12	1	ARHGEF12 [cytosol] (R-HSA-416560)	0.65	7
UniProt:P63103	2	YWHAZ [nucleoplasm] (R-BTA-450469) YWHAZ [cytosol] (R-BTA-206099)	0.593	3
UniProt:Q9UJU2 LEF1	2	LEF1 [nucleoplasm] (R-HSA-3214972) pT155,S166-LEF1 [nucleoplasm] (R-HSA-4411389)	0.576	5
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	3
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.567	8
UniProt:P05556 ITGB1	2	ITGB1 [endosome membrane] (R-HSA-9611157) ITGB1 [plasma membrane] (R-HSA-57596)	0.564	2
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.536	2
UniProt:Q13322 GRB10	2	p-Y GRB10 [cytosol] (R-HSA-9706168) GRB10 [cytosol] (R-HSA-110009)	0.527	2
UniProt:P29353-2 SHC1	6	SHC1-2 [plasma membrane] (R-HSA-2404168) p-S29,3Y-SHC1-2 [cytosol] (R-HSA-8934453) SHC1-2 [cytosol] (R-HSA-1169488) p-Y317-SHC1-2 [cytosol] (R-HSA-8851895) p-Y239,Y240,Y317-SHC1-2 [cytosol] (R-HSA-1433505) p-Y239,Y240,Y317-SHC1-2 [plasma membrane] (R-HSA-1169507)	0.508	2
UniProt:P35813 PPM1A	2	PPM1A [cytosol] (R-HSA-380928) PPM1A [nucleoplasm] (R-HSA-205813)	0.508	2
UniProt:P29350 PTPN6	5	PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.508	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.499	3
UniProt:Q14449 GRB14	1	GRB14 [cytosol] (R-HSA-204771)	0.488	2
UniProt:Q64010	1	Crk [cytosol] (R-MMU-2980677)	0.462	3