Reactome | GNB2 [plasma membrane]

GNB2 [plasma membrane]

Stable Identifier

R-HSA-164335

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-protein beta2 (GBB2) subunit

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein activation (Homo sapiens)
        
        The receptor:G-protein complex binds GTP (Homo sapiens)
        
        Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
        
        G-protein beta subunit [plasma membrane] (Homo sapiens)
        
        GNB2 [plasma membrane] (Homo sapiens)
        
        The receptor:G-protein complex releases GDP (Homo sapiens)
        
        Opioid:MOR:G-protein complex [plasma membrane] (Homo sapiens)
        
        Heterotrimeric G-protein [plasma membrane] (Homo sapiens)
        
        G-protein beta subunit [plasma membrane] (Homo sapiens)
        
        GNB2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62879 GNB2

Gene Names

GNB2

Chain

initiator methionine:1, chain:2-340

Reference Genes

BioGPS Gene:2783 GNB2

COSMIC (genes):GNB2 GNB2

CTD Gene:2783 GNB2

dbSNP Gene:2783 GNB2

ENSEMBL:ENSG00000172354.10 GNB2

HGNC:4398 GNB2

KEGG Gene (Homo sapiens):2783 GNB2

Monarch:2783 GNB2

NCBI Gene:2783 GNB2

OMIM:139390 GNB2

UCSC:P62879 GNB2

Reference Transcript

RefSeq:NM_005273.3 GNB2

Other Identifiers

0003830193

11756576_a_at

11756984_a_at

11756994_a_at

11756995_a_at

17049443

200852_3p_x_at

200852_PM_x_at

200852_x_at

2783

3015741

3015743

3015747

3015748

3015749

3015750

3015751

3015752

3015754

3015757

3015759

3015760

3015761

3015763

3015764

38831_f_at

38832_r_at

8134890

A_23_P82296

GO:0003924

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005834

GO:0005886

GO:0005925

GO:0007165

GO:0007186

GO:0016020

GO:0016787

GO:0023052

GO:0030159

GO:0031982

GO:0032991

GO:0043226

GO:0044877

GO:0048471

GO:0051020

GO:0055085

GO:0060090

GO:0070062

GO:1901379

HMNXSV003024661

ILMN_1658928

M36429_s_at

PH_hs_0029380

TC07000630.hg

g4885282_3p_x_at

Participates

as a candidate of

G-protein beta subunit [plasma membrane] (Homo sapiens)

Other forms of this molecule

Unfolded GNB2 [cytosol]

Partially folded GNB2 [cytosol]

GNB2 [cytosol]

Inferred To

Gnb2 [plasma membrane] (Mus musculus)

Gnb2 [plasma membrane] (Rattus norvegicus)

gpb-1 [plasma membrane] (Caenorhabditis elegans)

GNB2 [plasma membrane] (Bos taurus)

GNB2 [plasma membrane] (Canis familiaris)

GNB2 [plasma membrane] (Sus scrofa)

im:7138539 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_005264.2

OpenTargets

ENSG00000172354

HPA

ENSG00000172354-GNB2

GeneCards

P62879

Ensembl

ENSP00000305260, ENST00000303210, ENSP00000377501, ENSP00000400286, ENSP00000377503, ENST00000427895, ENSP00000390543, ENST00000393926, ENSG00000172354, ENST00000419828, ENST00000393924

PRO

P62879

Pharos - Targets

P62879

HMDB Protein

HMDBP08399

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	10
UniProt:P37840 SNCA	4	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:Q9NT62 ATG3	8	ATG3 [cytosol] (R-HSA-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379)	0.556	3
UniProt:P61077 UBE2D3	3	Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191) UBE2D3 [cytosol] (R-HSA-934630) UBE2D3 [nucleoplasm] (R-HSA-205341)	0.556	3
UniProt:P61081 UBE2M	5	AcM-UBE2M [nucleoplasm] (R-HSA-8952502) G76-NEDD8-C111-AcM-UBE2M [nucleoplasm] (R-HSA-8952508) UBE2M [cytosol] (R-HSA-947619) AcM-UBE2M [cytosol] (R-HSA-8951627) G76-NEDD8-C111-AcM-UBE2M [cytosol] (R-HSA-4419894)	0.556	3
UniProt:O14933 UBE2L6	2	UBE2L6 [cytosol] (R-HSA-936014) UBE2L6 [nucleoplasm] (R-HSA-5653666)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.556	3
UniProt:Q9NPD8 UBE2T	3	Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362) UBE2T [nucleoplasm] (R-HSA-420942)	0.556	3
UniProt:Q969M7 UBE2F	3	G76-NEDD8-C116-AcM-UBE2F [cytosol] (R-HSA-8951758) AcM-UBE2F [cytosol] (R-HSA-8951623) UBE2F [cytosol] (R-HSA-947635)	0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	3
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.547	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9

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