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Unfolded GNB2 [cytosol]
Stable Identifier
R-HSA-6814202
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Unfolded G-protein subunit beta-2
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Chaperonin-mediated protein folding (Homo sapiens)
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding (Homo sapiens)
ATP binds G-protein beta associated TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB2 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB2 [cytosol] (Homo sapiens)
ATP hydrolysis promotes folding of G-protein beta by TRiC/CCT (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ATP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB2 [cytosol] (Homo sapiens)
TRiC/CCT binds unfolded G-protein beta subunit (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB2 [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit:CCT/TRiC:ADP [cytosol] (Homo sapiens)
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Unfolded GNB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62879 GNB2
Gene Names
GNB2
Chain
initiator methionine:, chain:2-340
Reference Genes
BioGPS Gene:2783 GNB2
COSMIC (genes):GNB2 GNB2
CTD Gene:2783 GNB2
dbSNP Gene:2783 GNB2
ENSEMBL:ENSG00000172354 GNB2
ENSEMBL_homo_sapiens_GENE:ENSG00000172354.10 GNB2
HGNC:4398 GNB2
KEGG Gene (Homo sapiens):2783 GNB2
Monarch:2783 GNB2
NCBI Gene:2783 GNB2
OMIM:139390 GNB2
UCSC:P62879 GNB2
Reference Transcript
RefSeq:NM_005273.3 GNB2
Other Identifiers
11756576_a_at
11756984_a_at
11756994_a_at
11756995_a_at
17049443
200852_3p_x_at
200852_PM_x_at
200852_x_at
2783
3015741
3015743
3015747
3015748
3015749
3015750
3015751
3015752
3015754
3015757
3015759
3015760
3015761
3015763
3015764
38831_f_at
38832_r_at
8134890
A_23_P82296
GO:0003824
GO:0003924
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005765
GO:0005773
GO:0005829
GO:0005834
GO:0005886
GO:0005925
GO:0007165
GO:0007186
GO:0016020
GO:0016787
GO:0023052
GO:0030159
GO:0031982
GO:0043226
GO:0044877
GO:0048471
GO:0051020
GO:0055085
GO:0060090
GO:0070062
GO:1901379
HMNXSV003024661
ILMN_1658928
M36429_s_at
PH_hs_0029380
TC07000630.hg
g4885282_3p_x_at
Participates
as a member of
Unfolded G-protein beta subunit [cytosol] (Homo sapiens)
Other forms of this molecule
GNB2 [cytosol]
Partially folded GNB2 [cytosol]
GNB2 [plasma membrane]
Inferred To
STE4 [cytosol]
(Saccharomyces cerevisiae)
git5 [cytosol]
(Schizosaccharomyces pombe)
GNB2 [cytosol]
(Bos taurus)
GNB2 [cytosol]
(Canis familiaris)
GNB2 [cytosol]
(Sus scrofa)
gpb-1 [cytosol]
(Caenorhabditis elegans)
G-protein beta 2 subunit [cytosol]
(Mus musculus)
Gnb2 [cytosol]
(Rattus norvegicus)
Gbeta13F [cytosol]
(Drosophila melanogaster)
gpbA [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_005264.2
OpenTargets
ENSG00000172354
HPA
ENSG00000172354-GNB2
GeneCards
P62879
Ensembl
ENSP00000377503
,
ENSP00000400286
,
ENST00000303210
,
ENSG00000172354
,
ENST00000393926
,
ENST00000427895
,
ENST00000419828
,
ENSP00000390543
,
ENSP00000305260
,
ENSP00000377501
,
ENST00000393924
PRO
P62879
Pharos - Targets
P62879
PDB
9AVL
HMDB Protein
HMDBP08399
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.725
12
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:Q9NT62 ATG3
8
ATG3 [cytosol]
(R-HSA-5671860)
CysO264-ATG3-MAP1LC3A [cytosol]
(R-HSA-9819371)
CysO264-ATG3-GABARAP [cytosol]
(R-HSA-9819379)
CysO264-ATG3-GABARAPL3 [cytosol]
(R-HSA-5683569)
CysO264-ATG3-MAP1LC3B [cytosol]
(R-HSA-9819365)
CysO264-ATG3-GABARAPL1 [cytosol]
(R-HSA-9819381)
CysO264-ATG3-MAP1LC3C [cytosol]
(R-HSA-9819377)
CysO264-ATG3-GABARAPL2 [cytosol]
(R-HSA-9819376)
0.556
3
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
0.556
3
UniProt:P61081 UBE2M
5
AcM-UBE2M [nucleoplasm]
(R-HSA-8952502)
G76-NEDD8-C111-AcM-UBE2M [nucleoplasm]
(R-HSA-8952508)
UBE2M [cytosol]
(R-HSA-947619)
AcM-UBE2M [cytosol]
(R-HSA-8951627)
G76-NEDD8-C111-AcM-UBE2M [cytosol]
(R-HSA-4419894)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:O14933 UBE2L6
2
UBE2L6 [cytosol]
(R-HSA-936014)
UBE2L6 [nucleoplasm]
(R-HSA-5653666)
0.556
3
UniProt:Q9NPD8 UBE2T
3
Ub-C86-UBE2T [nucleoplasm]
(R-HSA-8864217)
UBE2T [nucleoplasm]
(R-HSA-420942)
MonoUb-K91,K182-UBE2T [nucleoplasm]
(R-HSA-6785362)
0.556
3
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.556
3
UniProt:Q9H0Y0 ATG10
2
GlyK166-ATG10 [cytosol]
(R-HSA-5683572)
ATG10 [cytosol]
(R-HSA-5671733)
0.556
3
UniProt:P61077 UBE2D3
3
UBE2D3 [nucleoplasm]
(R-HSA-205341)
UBE2D3 [cytosol]
(R-HSA-934630)
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
0.556
3
UniProt:Q969M7 UBE2F
3
G76-NEDD8-C116-AcM-UBE2F [cytosol]
(R-HSA-8951758)
AcM-UBE2F [cytosol]
(R-HSA-8951623)
UBE2F [cytosol]
(R-HSA-947635)
0.556
3
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.547
2
UniProt:Q13371 PDCL
2
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
PDCL [cytosol]
(R-HSA-6813727)
0.527
3
UniProt:P04083 ANXA1
2
ANXA1 [cytosol]
(R-HSA-5263630)
ANXA1 [extracellular region]
(R-HSA-444539)
0.527
2
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
3
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