Reactome | ANXA1 [cytosol]

ANXA1 [cytosol]

Stable Identifier

R-HSA-5263630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Annexin A1, ANXA1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04083 ANXA1

Gene Names

ANXA1, ANX1, LPC1

Chain

initiator methionine:1, chain:2-346, peptide:2-26

Reference Genes

BioGPS Gene:301 ANXA1

COSMIC (genes):ANXA1 ANXA1

CTD Gene:301 ANXA1

dbSNP Gene:301 ANXA1

ENSEMBL:ENSG00000135046 ANXA1

HGNC:533 ANXA1

KEGG:hsa:301 ANXA1

Monarch:301 ANXA1

NCBI Entrez Gene:301 ANXA1

OMIM:151690 ANXA1

UCSC:P04083 ANXA1

Reference Transcript

Other Identifiers

11717514_a_at

11744953_a_at

11744954_x_at

11744955_a_at

11759797_at

17085901

201012_PM_at

201012_at

301

3174820

3174821

3174823

3174824

3174826

3174827

3174828

3174829

3174830

3174831

3174832

3174833

3174834

3174835

3174836

3174838

3174840

3174841

3174842

3174845

3174846

3174847

3174848

3174850

3174851

3174852

3174853

3174856

3174857

37403_at

8155849

A_14_P122797

A_23_P94501

GE59671

GE84897

GO:0001533

GO:0001780

GO:0001786

GO:0001891

GO:0002250

GO:0002376

GO:0002548

GO:0002685

GO:0004859

GO:0005102

GO:0005509

GO:0005515

GO:0005543

GO:0005544

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005884

GO:0005886

GO:0005912

GO:0005925

GO:0005929

GO:0006909

GO:0006954

GO:0007165

GO:0007166

GO:0007187

GO:0008289

GO:0008360

GO:0009986

GO:0010008

GO:0012506

GO:0014839

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0016328

GO:0018149

GO:0019834

GO:0030036

GO:0030154

GO:0030216

GO:0030312

GO:0030659

GO:0031012

GO:0031340

GO:0031410

GO:0031514

GO:0031901

GO:0031982

GO:0032652

GO:0032717

GO:0032743

GO:0033031

GO:0035924

GO:0042102

GO:0042119

GO:0042127

GO:0042383

GO:0042995

GO:0043066

GO:0043226

GO:0045087

GO:0045627

GO:0045629

GO:0045920

GO:0046632

GO:0046872

GO:0046883

GO:0048306

GO:0048870

GO:0050482

GO:0050727

GO:0051051

GO:0051240

GO:0070062

GO:0071385

GO:0071621

GO:0090050

GO:0090303

GO:0097350

GO:0098542

GO:0098609

GO:0098641

GO:0098772

GO:1900087

HMNXSV003032171

ILMN_2184184

PH_hs_0023492

TC09000335.hg

X05908_at

g4502100_3p_s_at

Participates

as a component of

CAV3:TRIM72:DYSF:ANXA6:ANXA1:ANXA2 [plasma membrane] (Homo sapiens)

as an input of

CAV3:TRIM72:DYSF binds ANXAs (Homo sapiens)

as a protein marker of

pancreatic ductal cell (Homo sapiens)

Other forms of this molecule

ANXA1 [extracellular region]

Cross References

RefSeq

NP_000691.1, XP_011516911.1, XP_054218829.1

OpenTargets

ENSG00000135046

ENSEMBL

ENST00000257497, ENSP00000366109, ENSG00000135046, ENST00000376911, ENSP00000257497

HPA

ENSG00000135046-ANXA1

GeneCards

ANXA1

PRO

P04083

Pharos - Targets

P04083

GlyGen

P04083

PDB

5VFW, 1AIN, 1QLS, 1BO9

HMDB Protein

HMDBP07452

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.772	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.558	3
UniProt:Q13546 RIPK1	20	RIPK1 [cytosol] (R-HSA-168651) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) p-S166-RIPK1 [cytosol] (R-HSA-5218872) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S320-RIPK1 [cytosol] (R-HSA-9815498) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1(1-324) [cytosol] (R-HSA-5212664) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324N [cytosol] (R-HSA-9693930) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308)	0.556	5
UniProt:Q9C0E8-2 LNPK			0.556	3
UniProt:Q9NVM1 EVA1B			0.556	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.556	6
UniProt:Q6P5S2 LEG1H			0.556	3
UniProt:Q96EF9 ZHX1R			0.556	3
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) STK4(327-487) [cytosol] (R-HSA-2028668) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258)	0.527	2
UniProt:Q8N878 FRMD1			0.527	2
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.527	2
UniProt:P43631 KIR2DS2	1	KIR2DS2 [plasma membrane] (R-HSA-199534)	0.527	2
UniProt:A0A0F6AZQ1 A0A0F6AZQ1			0.499	2
UniProt:A0A0F6B5H5 A0A0F6B5H5			0.499	2

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