Reactome | SMN1 [nucleoplasm]

SMN1 [nucleoplasm]

Stable Identifier

R-HSA-191892

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SMN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16637 SMN1

Gene Names

SMN1, SMN, SMNT, SMN2, SMNC

Chain

initiator methionine:, chain:2-294

Reference Genes

COSMIC (genes):SMN1 SMN1

COSMIC (genes):SMN2 SMN1

dbSNP Gene:6606 SMN1

dbSNP Gene:6607 SMN1

ENSEMBL:ENSG00000172062 SMN1

ENSEMBL:ENSG00000205571 SMN1

Participates

as a component of

SMN complex [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SMN1 [cytosol]

Inferred To

Smn1 [nucleoplasm] (Mus musculus)

Smn1 [nucleoplasm] (Rattus norvegicus)

SMN [nucleoplasm] (Canis familiaris)

SMN [nucleoplasm] (Gallus gallus)

Ghost homologue of SMN1 [nucleoplasm] (Sus scrofa)

SMN1 [nucleoplasm] (Bos taurus)

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [cytosol] (R-HSA-192217) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215)	0.839	7
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.801	6
UniProt:P62308 SNRPG	2	SNRPG [cytosol] (R-HSA-191827) SNRPG [nucleoplasm] (R-HSA-71909)	0.793	6
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.788	7
UniProt:P62316 SNRPD2	2	SNRPD2 [cytosol] (R-HSA-191810) SNRPD2 [nucleoplasm] (R-HSA-71901)	0.725	5
UniProt:Q9Y3F4 STRAP	1	STRAP [cytosol] (R-HSA-2127556)	0.725	4
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.718	6
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.718	6
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.718	8
UniProt:Q13427 PPIG	2	PPIG [nucleoplasm] (R-HSA-9769592) PPIG [cytosol] (R-HSA-9728768)	0.666	4
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.643	5
UniProt:O14744 PRMT5	3	PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609) p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300)	0.597	3
UniProt:P62320	3	Snrpd3 [nucleoplasm] (R-MMU-71903) Snrpd3 [nucleoplasm] (R-MMU-192219) Snrpd3 [cytosol] (R-MMU-191781)	0.561	3
UniProt:P62317	2	Snrpd2 [nucleoplasm] (R-MMU-71901) Snrpd2 [cytosol] (R-MMU-191810)	0.561	3
UniProt:P62315	3	Snrpd1 [nucleoplasm] (R-MMU-192215) Snrpd1 [cytosol] (R-MMU-191890) Snrpd1 [cytosol] (R-MMU-192217)	0.561	3
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.558	5
UniProt:Q96FZ7 CHMP6	2	CHMP6 [endosome membrane] (R-HSA-9631195) CHMP6 [cytosol] (R-HSA-917736)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q9Y3Y2 CHTOP	1	CHTOP [nucleoplasm] (R-HSA-8849147)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.547	2
UniProt:P62307	2	Snrpf [nucleoplasm] (R-MMU-71907) Snrpf [cytosol] (R-MMU-191852)	0.544	2
UniProt:Q9NY12 GAR1	1	GAR1 [nucleoplasm] (R-HSA-6790707)	0.544	2
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.524	3
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.508	2

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