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PI3K alpha [cytosol]
Stable Identifier
R-HSA-198379
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Signaling by KIT in disease (Homo sapiens)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants (Homo sapiens)
KIT mutants:PI3K catalyze synthesis of PIP3 (Homo sapiens)
PI3K:p-KIT mutant dimers [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Phosphorylated KIT mutants bind PI3K (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p-KIT mutant dimers [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Homo sapiens)
PI3K alpha, beta, gamma [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-stimulation by CD28 (Homo sapiens)
CD28 dependent PI3K/Akt signaling (Homo sapiens)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K binds CD28 (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Co-stimulation by ICOS (Homo sapiens)
PI3K binds ICOS (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
14-3-3 zeta binding allows recruitment of PI3K (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL is tyrosine phosphorylated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
CD28:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
ICOS:PI3K [plasma membrane] (Homo sapiens)
Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC1,RAC2,RHOG activate PI3K (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
G alpha (q) inhibits PI3K alpha (Homo sapiens)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
PI3K binds membrane-associated estrogen receptors (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PTK2 is recruited to methylated ESR1 (Homo sapiens)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Homo sapiens)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Direct recruitment of PI3K to p-KIT (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Synthesis of PIP3 from PIP2 by PI3K (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC2 GTPase cycle (Homo sapiens)
RAC2 binds effectors at the plasma membrane (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Homo sapiens)
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
PI3K alpha [cytosol] (Homo sapiens)
Participants
components
PI3K-regulatory subunits [cytosol]
(Homo sapiens)
PIK3CA [cytosol]
(Homo sapiens)
Participates
as a member of
RAC2 plasma membrane effectors [cytosol] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
PI3K alpha, beta, gamma [cytosol] (Homo sapiens)
as an input of
Phosphorylated KIT mutants bind PI3K (Homo sapiens)
PI3K binds membrane-associated estrogen receptors (Homo sapiens)
G alpha (q) inhibits PI3K alpha (Homo sapiens)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Homo sapiens)
RAC1,RAC2,RHOG activate PI3K (Homo sapiens)
Direct recruitment of PI3K to p-KIT (Homo sapiens)
as a component of
PI3K:p-KIT mutant dimers [plasma membrane] (Homo sapiens)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Homo sapiens)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Homo sapiens)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Homo sapiens)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Homo sapiens)
as a candidate of
Class 1A PI3Ks [cytosol] (Homo sapiens)
Inferred To
PI3K [cytosol]
(Caenorhabditis elegans)
PIK3CA:PIK3R1 [cytosol]
(Drosophila melanogaster)
PI3K alpha [cytosol]
(Bos taurus)
PI3K alpha [cytosol]
(Canis familiaris)
PI3K alpha [cytosol]
(Danio rerio)
PI3K alpha [cytosol]
(Gallus gallus)
PI3K alpha [cytosol]
(Mus musculus)
PI3K alpha [cytosol]
(Rattus norvegicus)
PI3K alpha [cytosol]
(Sus scrofa)
PI3K alpha [cytosol]
(Xenopus tropicalis)
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