Reactome | HIST1H1C [nucleoplasm]

HIST1H1C [nucleoplasm]

Stable Identifier

R-HSA-211237

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

histone H1.2

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
        
        SAHF formation (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1C [nucleoplasm] (Homo sapiens)
        
        Histone H1 bound chromatin DNA [nucleoplasm] (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1C [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16403 H1-2

Gene Names

H1-2, H1F2, HIST1H1C

Chain

initiator methionine:, chain:2-213

Reference Genes

COSMIC (genes):HIST1H1C H1-2

ENSEMBL:ENSG00000187837 HIST1H1C

HGNC:4716 H1-2

UCSC:P16403 H1-2

Other Identifiers

11742683_x_at

17016372

209398_PM_at

209398_at

2946233

2946234

2946235

2946236

2946237

2946238

3006

37018_at

8124397

A_23_P122443

GE81491

GO:0000122

GO:0000786

GO:0000791

GO:0003677

GO:0003690

GO:0003723

GO:0005198

GO:0005515

GO:0005634

GO:0005694

GO:0006325

GO:0006334

GO:0006355

GO:0006357

GO:0030261

GO:0030527

GO:0031490

GO:0031492

GO:0043226

GO:0045910

GO:0065003

HMNXSV003036784

ILMN_1757406

PH_hs_0000789

PH_hs_0039512

TC06001345.hg

TC06003537.hg

X57129_at

g12803628_3p_at

Participates

as a candidate of

Histone H1 [nucleoplasm] (Homo sapiens)

Inferred To

H1f2 [nucleoplasm] (Rattus norvegicus)

HHO1 [nucleoplasm] (Saccharomyces cerevisiae)

HIST1H1C [nucleoplasm] (Danio rerio)

H1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of HIST1H1C [nucleoplasm] (Danio rerio)

si:dkey-261m9.14 [nucleoplasm] (Danio rerio)

histh1l1 [nucleoplasm] (Danio rerio)

H1-2 [nucleoplasm] (Mus musculus)

Cross References

ENSEMBL

ENSP00000339566, ENST00000343677

OpenTargets

ENSG00000187837

HPA

ENSG00000187837-H1-2

PRO

P16403

Pharos - Targets

P16403

GlyGen

P16403

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.725	4
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.643	4
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.564	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.564	2
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.564	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	3

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