Reactome | HIST1H1C [nucleoplasm]

HIST1H1C [nucleoplasm]

Stable Identifier

R-HSA-211237

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

histone H1.2

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
        
        SAHF formation (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1C [nucleoplasm] (Homo sapiens)
        
        Histone H1 bound chromatin DNA [nucleoplasm] (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1C [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16403 H1-2

Gene Names

H1-2, H1F2, HIST1H1C

Chain

initiator methionine:1, chain:2-213

Reference Genes

BioGPS Gene:3006 H1-2

CTD Gene:3006 H1-2

dbSNP Gene:3006 H1-2

ENSEMBL:ENSG00000187837.4 H1-2

HGNC:4716 H1-2

KEGG Gene (Homo sapiens):3006 H1-2

Monarch:3006 H1-2

NCBI Gene:3006 H1-2

OMIM:142710 H1-2

UCSC:P16403 H1-2

Reference Transcript

RefSeq:NM_005319.3 H1-2

Other Identifiers

0001990139

11742683_x_at

17016372

209398_PM_at

209398_at

2946234

2946235

2946236

2946237

2946238

3006

37018_at

8124397

A_23_P122443

GE81491

GO:0000122

GO:0000786

GO:0000791

GO:0003677

GO:0003690

GO:0003723

GO:0005198

GO:0005515

GO:0005622

GO:0005634

GO:0005694

GO:0006310

GO:0006325

GO:0006334

GO:0006351

GO:0006355

GO:0006357

GO:0030261

GO:0030527

GO:0031490

GO:0031492

GO:0032991

GO:0036211

GO:0043226

GO:0045910

GO:0065003

GO:0080182

GO:0098532

HMNXSV003036784

ILMN_1757406

PH_hs_0000789

TC06001345.hg

TC06003537.hg

X57129_at

g12803628_3p_at

Participates

as a candidate of

Histone H1 [nucleoplasm] (Homo sapiens)

Inferred To

si:ch1073-153i20.4 [nucleoplasm] (Danio rerio)

LOC116407574 [nucleoplasm] (Xenopus tropicalis)

HIST1H1C [nucleoplasm] (Danio rerio)

HIST1H1C [nucleoplasm] (Sus scrofa)

HIST1H1C [nucleoplasm] (Xenopus tropicalis)

si:ch73-36p18.1 [nucleoplasm] (Danio rerio)

H1 [nucleoplasm] (Dictyostelium discoideum)

Homologues of HIST1H1C [nucleoplasm] (Danio rerio)

Homologues of HIST1H1C [nucleoplasm] (Xenopus tropicalis)

LOC101730703 [nucleoplasm] (Xenopus tropicalis)

LOC101733134 [nucleoplasm] (Xenopus tropicalis)

HHO1 [nucleoplasm] (Saccharomyces cerevisiae)

LOC101734931 [nucleoplasm] (Xenopus tropicalis)

LOC101732876 [nucleoplasm] (Xenopus tropicalis)

si:ch211-113a14.24 [nucleoplasm] (Danio rerio)

si:ch1073-159d7.7 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_005310.1

OpenTargets

ENSG00000187837

GeneCards

P16403

HPA

ENSG00000187837-H1-2

Ensembl

ENSG00000187837, ENST00000343677, ENSP00000339566

PRO

P16403

Pharos - Targets

P16403

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.643	3
UniProt:P67809 YBX1	3	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.462	3