Reactome | RBBP4 [nucleoplasm]

RBBP4 [nucleoplasm]

Stable Identifier

R-HSA-212223

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RbAp48, CAF1C

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q09028 RBBP4

Gene Names

RBBP4, RBAP48

Chain

initiator methionine:1, chain:2-425

Reference Genes

BioGPS Gene:5928 RBBP4

COSMIC (genes):RBBP4 RBBP4

CTD Gene:5928 RBBP4

dbSNP Gene:5928 RBBP4

ENSEMBL:ENSG00000162521 RBBP4

ENSEMBL:ENSG00000162521.19 RBBP4

HGNC:9887 RBBP4

KEGG Gene (Homo sapiens):5928 RBBP4

Monarch:5928 RBBP4

NCBI Gene:5928 RBBP4

OMIM:602923 RBBP4

UCSC:Q09028 RBBP4

Reference Transcript

Other Identifiers

11717239_s_at

11717240_at

1318_at

16662134

210371_PM_s_at

210371_s_at

217301_PM_x_at

217301_x_at

225396_PM_at

225396_at

2328991

2328992

2328993

2328997

2329000

2329004

2329005

2329006

2329007

2329008

2329009

2329010

2329011

2329012

2329013

2329018

2329019

2329020

2329021

2329022

2329023

237333_PM_at

237333_at

244872_PM_at

2685376

2685379

2685382

2685383

2849593

2849594

2849595

2849597

2849603

2958818

2958991

3413945

40418_at

45346_at

5928

62219_r_at

72157_at

7899813

A_14_P106341

A_14_P134827

A_23_P326691

A_23_P45902

A_24_P468810

A_33_P3232562

A_33_P3338559

GE59990

GE86924

GO:0000118

GO:0000122

GO:0000228

GO:0000781

GO:0000785

GO:0000978

GO:0003677

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006260

GO:0006325

GO:0006334

GO:0006335

GO:0006338

GO:0006351

GO:0006355

GO:0007049

GO:0007420

GO:0008094

GO:0008285

GO:0016575

GO:0016580

GO:0016581

GO:0016589

GO:0023052

GO:0030154

GO:0030336

GO:0030512

GO:0031492

GO:0032991

GO:0033186

GO:0035098

GO:0036211

GO:0042393

GO:0042659

GO:0042826

GO:0043226

GO:0045892

GO:0045893

GO:0048856

GO:0048870

GO:0065003

GO:0140097

GO:0140657

GO:1902455

GO:1902459

GO:1904949

GO:2000736

HMNXSV003033305

Hs.16003.3.S1_3p_x_at

Hs.271441.0.A1_3p_at

Hs.308800.0.A1_3p_at

Hs.331328.0.A1_3p_at

ILMN_1653514

ILMN_2062524

PH_hs_0037097

PH_hs_0039854

TC01000433.hg

X74262_at

g13111850_3p_a_at

Participates

as a component of

as an output of

RBBP4 gene expression is inhibited by E2F6 (Homo sapiens)

as an input of

Formation of PRC2-EZH2 complex (Homo sapiens)

as a member of

RBBP4,7 [nucleoplasm] (Homo sapiens)

Inferred To

MSI1 [nucleoplasm] (Saccharomyces cerevisiae)

Rbbp4 [nucleoplasm] (Mus musculus)

Rbbp4 [nucleoplasm] (Rattus norvegicus)

rba-1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of RBBP4 [nucleoplasm] (Caenorhabditis elegans)

Homologues of RBBP4 [nucleoplasm] (Dictyostelium discoideum)

Homologues of RBBP4 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RBBP4 [nucleoplasm] (Schizosaccharomyces pombe)

Caf1-55 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of RBBP4 [nucleoplasm] (Sus scrofa)

WTM1 [nucleoplasm] (Saccharomyces cerevisiae)

prw1 [nucleoplasm] (Schizosaccharomyces pombe)

WTM2 [nucleoplasm] (Saccharomyces cerevisiae)

mis16 [nucleoplasm] (Schizosaccharomyces pombe)

rbbD [nucleoplasm] (Dictyostelium discoideum)

UME1 [nucleoplasm] (Saccharomyces cerevisiae)

HAT2 [nucleoplasm] (Saccharomyces cerevisiae)

RBBP4 [nucleoplasm] (Bos taurus)

RBBP4 [nucleoplasm] (Canis familiaris)

RBBP4 [nucleoplasm] (Dictyostelium discoideum)

RBBP4 [nucleoplasm] (Gallus gallus)

RBBP4 [nucleoplasm] (Schizosaccharomyces pombe)

rbbp4 [nucleoplasm] (Danio rerio)

rbbp4 [nucleoplasm] (Xenopus tropicalis)

lin-53 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001128728.1, NP_005601.1, NP_001128727.1

OpenTargets

ENSG00000162521

GeneCards

Q09028

HPA

ENSG00000162521-RBBP4

Ensembl

ENSP00000362584, ENSP00000398242, ENSP00000362592, ENST00000373485, ENST00000373493, ENSP00000396057, ENST00000414241, ENST00000458695, ENSG00000162521

PRO

Q09028

Pharos - Targets

Q09028

PDB

5XXQ, 6WKR, 4PBY, 6C24, 7AOA, 3GFC, 2XU7, 6C23, 5WAK, 4R7A, 6G16, 6BW4, 5VTB, 5WAI, 5XWR, 7KSR, 6BW3, 7N40, 5FXY, 5Y1U, 7R1D, 7KSO, 6ZRD, 6ZRC, 6NQ3, 7M40, 4PC0, 4PBZ, 7KTP

Interactors (72)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.895	8
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.832	10
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.788	7
UniProt:P68431 H3C1	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.788	5
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.725	5
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.725	5
UniProt:P28370 SMCA1			0.723	5
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.69	4
UniProt:O14929 HAT1	1	HAT1 [nucleoplasm] (R-HSA-3662337)	0.666	4
UniProt:Q8IX07 ZFPM1	1	ZFPM1 [nucleoplasm] (R-HSA-996748)	0.655	4
UniProt:Q6ZN18 AEBP2	1	AEBP2 [nucleoplasm] (R-HSA-5082342)	0.648	4
UniProt:Q03112 MECOM	2	MECOM [cytosol] (R-HSA-5634790) MECOM [nucleoplasm] (R-HSA-8943897)	0.645	4
UniProt:Q13112 CAF1B			0.643	4
UniProt:Q96GY3 LIN37	1	LIN37 [nucleoplasm] (R-HSA-389101)	0.643	3
UniProt:Q13111 CAF1A			0.643	3
UniProt:O14519 CDKA1			0.643	3
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.643	3
UniProt:Q5TKA1 LIN9	1	LIN9 [nucleoplasm] (R-HSA-389108)	0.643	3
UniProt:Q12830 BPTF			0.643	3
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.643	4
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.643	3
UniProt:Q14839 CHD4	1	CHD4 [nucleoplasm] (R-HSA-3702078)	0.643	4
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.643	4
UniProt:Q96ST3 SIN3A	2	SIN3A [nucleoplasm] (R-HSA-351657) monoSUMO1-SIN3A [nucleoplasm] (R-HSA-4086071)	0.643	3
UniProt:Q9UBB5 MBD2	1	MBD2 [nucleoplasm] (R-HSA-427367)	0.643	3
UniProt:Q9HAZ2 PRDM16	1	PRDM16 [cytosol] (R-HSA-5634812)	0.618	3
UniProt:Q9NVP2 ASF1B			0.564	2
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:P30038 ALDH4A1	1	ALDH4A1 [mitochondrial matrix] (R-HSA-70673)	0.556	3
UniProt:O94985-2 CLSTN1			0.556	3
UniProt:Q9BRL8 Q9BRL8			0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:P36544 CHRNA7	1	CHRNA7 [plasma membrane] (R-HSA-507830)	0.556	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.556	3
UniProt:P51692 STAT5B	5	STAT5B [cytosol] (R-HSA-380737) p-Y699-STAT5B [cytosol] (R-HSA-507939) p-STAT5B [cytosol] (R-HSA-8983127) p-STAT5B [nucleoplasm] (R-HSA-8982834) p-Y699-STAT5B [nucleoplasm] (R-HSA-508016)	0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:P60201-2 PLP1			0.556	3
UniProt:P21333-2 FLNA			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P02768-3 ALB			0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:Q92800 EZH1			0.527	2
UniProt:Q9Y483 MTF2	1	MTF2 [nucleoplasm] (R-HSA-5084119)	0.527	3
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.527	2
UniProt:Q9H165 BCL11A	2	BCL11A(1-219)insDHPPA-ALK(1058-1620) fusion [cytosol] (R-HSA-9713444) BCL11A(1-219)insDHPPA-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713447)	0.527	2
UniProt:Q8NCD3 HJURP	1	HJURP [nucleoplasm] (R-HSA-606331)	0.527	2
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.527	2
UniProt:Q8IXM2 BAP18			0.527	2
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.527	2
UniProt:Q96JN0 LCOR			0.527	2
UniProt:Q52LA3 LIN52	2	p-S28-LIN52 [nucleoplasm] (R-HSA-1362251) LIN52 [nucleoplasm] (R-HSA-389107)	0.527	2
UniProt:Q96KM6 ZNF512B	1	ZNF512B [cytosol] (R-HSA-9715175)	0.527	2
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.527	2
UniProt:Q96N64 PWP2A			0.527	2
UniProt:Q6MZP7 LIN54	1	LIN54 [nucleoplasm] (R-HSA-389103)	0.527	2
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.527	2
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.527	3
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.527	3
UniProt:P84243 H3-3A	17	MeK-H3F3A [nucleoplasm] (R-HSA-427369) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) H3R17me2a [nucleoplasm] (R-HSA-9822613) H3F3A [extracellular region] (R-HSA-977567) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.527	2
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.527	2
UniProt:P10244 MYBL2	1	MYBL2 [nucleoplasm] (R-HSA-389106)	0.527	2
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.527	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.499	2
UniProt:A2A935	1	Prdm16 [cytosol] (R-MMU-5634812)	0.462	3
UniProt:Q8N5A5 ZGPAT			0.462	2
UniProt:Q08999 RBL2	2	RBL2 [nucleoplasm] (R-HSA-389102) p-T401,S672,S1035-RBL2 [nucleoplasm] (R-HSA-1226084)	0.462	4
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2

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