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ADCYAP1(132-158) [extracellular region]
Stable Identifier
R-HSA-420144
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Pituitary adenylate cyclase-activating polypeptide-27, ADCYAP1, PACA_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Glucagon-type ligand receptors (Homo sapiens)
The PACAP receptor binds PACAP (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
ADCYAP1R1:ADCYAP1 peptides [plasma membrane] (Homo sapiens)
ADCYAP1 peptides [extracellular region] (Homo sapiens)
ADCYAP1(132-158) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18509 ADCYAP1
Gene Names
ADCYAP1
Chain
signal peptide:1-24, propeptide:25-79, peptide:82-129, peptide:132-169, peptide:132-158, propeptide:173-176
Reference Genes
BioGPS Gene:116 ADCYAP1
COSMIC (genes):ADCYAP1 ADCYAP1
CTD Gene:116 ADCYAP1
dbSNP Gene:116 ADCYAP1
ENSEMBL:ENSG00000141433 ADCYAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000141433.13 ADCYAP1
HGNC:241 ADCYAP1
KEGG Gene (Homo sapiens):116 ADCYAP1
Monarch:116 ADCYAP1
NCBI Gene:116 ADCYAP1
OMIM:102980 ADCYAP1
UCSC:P18509 ADCYAP1
Reference Transcript
RefSeq:NM_001117.4 ADCYAP1
RefSeq:NM_001099733.1 ADCYAP1
Other Identifiers
116
11729961_a_at
11729962_a_at
11738170_a_at
16850487
206281_PM_at
206281_at
230237_PM_at
230237_at
36754_at
3775921
3775922
3775923
3775924
3775930
3775932
3775936
3775937
3775938
3775939
3775940
3775941
3775942
3775943
3775944
48934_at
8019851
A_23_P38712
A_24_P335781
A_33_P3392092
GE59860
GO:0005102
GO:0005179
GO:0005184
GO:0005515
GO:0005576
GO:0006351
GO:0006355
GO:0007189
GO:0007190
GO:0007204
GO:0007218
GO:0007267
GO:0007399
GO:0007565
GO:0008277
GO:0010628
GO:0016521
GO:0019933
GO:0022414
GO:0023052
GO:0030073
GO:0030154
GO:0031175
GO:0032879
GO:0032880
GO:0036211
GO:0043005
GO:0043204
GO:0043547
GO:0045786
GO:0045860
GO:0045944
GO:0048018
GO:0048856
GO:0051428
GO:0060124
GO:0070374
GO:0071651
GO:0098772
GO:0120162
HMNXSV003030076
Hs.95469.0.A1_3p_at
ILMN_1763344
PH_hs_0004082
S83513_s_at
TC18000007.hg
g10947062_3p_at
Participates
as a member of
ADCYAP1 peptides [extracellular region] (Homo sapiens)
Other forms of this molecule
ADCYAP1(82-129) [extracellular region]
ADCYAP1(132-169) [extracellular region]
ADCYAP1(2-742) [Golgi membrane]
Inferred To
ADCYAP1 [extracellular region]
(Bos taurus)
ADCYAP1 [extracellular region]
(Canis familiaris)
ADCYAP1 [extracellular region]
(Sus scrofa)
PACAP [extracellular region]
(Gallus gallus)
adcyap1b [extracellular region]
(Danio rerio)
Adcyap1 [extracellular region]
(Mus musculus)
Adcyap1 [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_001108.2
,
NP_001093203.1
OpenTargets
ENSG00000141433
HPA
ENSG00000141433-ADCYAP1
GeneCards
P18509
Ensembl
ENSG00000141433
,
ENST00000579794
,
ENST00000450565
,
ENSP00000462647
,
ENSP00000411658
ZINC target
P18509
PRO
P18509
Pharos - Targets
P18509
PDB
6VN7
,
6M1I
,
1GEA
,
8E3X
,
2JOD
,
8E3Y
,
7VQX
,
6P9Y
,
6LPB
,
7WBJ
,
2D2P
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41586-3 ADCYAP1R1
0.558
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P10909 CLU
4
CLU(23-449) [extracellular region]
(R-HSA-349732)
CLU(23-449) [platelet alpha granule lumen]
(R-HSA-349733)
CLU(228-449) [extracellular region]
(R-HSA-6810626)
CLU(23-227) [extracellular region]
(R-HSA-6810660)
0.543
4
UniProt:Q6IN85 P4R3A
0.527
2
UniProt:Q02818 NUCB1
2
p-NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8957027)
NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8956751)
0.527
2
UniProt:Q8IWJ2 GCC2
3
GCC2 [cytosol]
(R-HSA-6813880)
GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713455)
GCC2(1-1204)-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713458)
0.527
2
UniProt:P17707 AMD1
1
AMD1(1-67) [cytosol]
(R-HSA-351223)
0.527
2
UniProt:Q9UHG2 PCS1N
0.527
2
UniProt:P54105 CLNS1A
1
CLNS1A [cytosol]
(R-HSA-191796)
0.527
2
UniProt:Q9H4B6 SAV1
2
SAV1 [cytosol]
(R-HSA-2028283)
p-SAV1 [cytosol]
(R-HSA-2028276)
0.527
2
UniProt:O95749 GGPS1
1
GGPS1 [cytosol]
(R-HSA-191415)
0.527
2
UniProt:Q9Y5J6 TIMM10B
1
4xHC-TIMM10B [mitochondrial inner membrane]
(R-HSA-1252043)
0.527
2
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.527
2
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