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ADCYAP1(2-742) [Golgi membrane]
Stable Identifier
R-HSA-187679
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi membrane
Synonyms
Pituitary adenylate cyclase activating polypeptide precursor, PACA_HUMAN, ADCYAP1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Activation of TRKA receptors (Homo sapiens)
NGF-independant TRKA activation (Homo sapiens)
ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)
ADCYAP1(2-742) [Golgi membrane] (Homo sapiens)
ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 [Golgi membrane] (Homo sapiens)
ADCYAP1(2-742) [Golgi membrane] (Homo sapiens)
NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates (Homo sapiens)
ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 [Golgi membrane] (Homo sapiens)
ADCYAP1(2-742) [Golgi membrane] (Homo sapiens)
ADCYAP1(2-742):ADCYAP1R1:p-5Y-NTRK1,p-5Y-NTRK2 [Golgi membrane] (Homo sapiens)
ADCYAP1(2-742) [Golgi membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18509 ADCYAP1
Gene Names
ADCYAP1
Chain
signal peptide:1-24, propeptide:25-79, peptide:82-129, peptide:132-169, peptide:132-158, propeptide:173-176
Reference Genes
BioGPS Gene:116 ADCYAP1
COSMIC (genes):ADCYAP1 ADCYAP1
CTD Gene:116 ADCYAP1
dbSNP Gene:116 ADCYAP1
ENSEMBL:ENSG00000141433 ADCYAP1
ENSEMBL_homo_sapiens_GENE:ENSG00000141433.13 ADCYAP1
HGNC:241 ADCYAP1
KEGG Gene (Homo sapiens):116 ADCYAP1
Monarch:116 ADCYAP1
NCBI Gene:116 ADCYAP1
OMIM:102980 ADCYAP1
UCSC:P18509 ADCYAP1
Reference Transcript
RefSeq:NM_001117.4 ADCYAP1
RefSeq:NM_001099733.1 ADCYAP1
Other Identifiers
116
11729961_a_at
11729962_a_at
11738170_a_at
16850487
206281_PM_at
206281_at
230237_PM_at
230237_at
36754_at
3775921
3775922
3775923
3775924
3775930
3775932
3775936
3775937
3775938
3775939
3775940
3775941
3775942
3775943
3775944
48934_at
8019851
A_23_P38712
A_24_P335781
A_33_P3392092
GE59860
GO:0005102
GO:0005179
GO:0005184
GO:0005515
GO:0005576
GO:0006351
GO:0006355
GO:0007189
GO:0007190
GO:0007204
GO:0007218
GO:0007267
GO:0007399
GO:0007565
GO:0008277
GO:0010628
GO:0016521
GO:0019933
GO:0022414
GO:0023052
GO:0030073
GO:0030154
GO:0031175
GO:0032879
GO:0032880
GO:0036211
GO:0043005
GO:0043204
GO:0043547
GO:0045786
GO:0045860
GO:0045944
GO:0048018
GO:0048856
GO:0051428
GO:0060124
GO:0070374
GO:0071651
GO:0098772
GO:0120162
HMNXSV003030076
Hs.95469.0.A1_3p_at
ILMN_1763344
PH_hs_0004082
S83513_s_at
TC18000007.hg
g10947062_3p_at
Participates
as an input of
ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2 (Homo sapiens)
as a component of
ADCYAP1(2-742):ADCYAP1R1:p-5Y-NTRK1,p-5Y-NTRK2 [Golgi membrane] (Homo sapiens)
ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 [Golgi membrane] (Homo sapiens)
Other forms of this molecule
ADCYAP1(132-158) [extracellular region]
ADCYAP1(82-129) [extracellular region]
ADCYAP1(132-169) [extracellular region]
Cross References
RefSeq
NP_001108.2
,
NP_001093203.1
OpenTargets
ENSG00000141433
HPA
ENSG00000141433-ADCYAP1
GeneCards
P18509
Ensembl
ENSG00000141433
,
ENST00000579794
,
ENST00000450565
,
ENSP00000462647
,
ENSP00000411658
ZINC target
P18509
PRO
P18509
Pharos - Targets
P18509
PDB
6VN7
,
6M1I
,
1GEA
,
8E3X
,
2JOD
,
8E3Y
,
7VQX
,
6P9Y
,
6LPB
,
7WBJ
,
2D2P
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41586-3 ADCYAP1R1
0.558
2
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P10909 CLU
4
CLU(23-449) [extracellular region]
(R-HSA-349732)
CLU(23-449) [platelet alpha granule lumen]
(R-HSA-349733)
CLU(228-449) [extracellular region]
(R-HSA-6810626)
CLU(23-227) [extracellular region]
(R-HSA-6810660)
0.543
4
UniProt:Q6IN85 P4R3A
0.527
2
UniProt:Q02818 NUCB1
2
p-NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8957027)
NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8956751)
0.527
2
UniProt:Q8IWJ2 GCC2
3
GCC2 [cytosol]
(R-HSA-6813880)
GCC2(1-1204)-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713455)
GCC2(1-1204)-ALK(1059-1620) fusion [cytosol]
(R-HSA-9713458)
0.527
2
UniProt:P17707 AMD1
1
AMD1(1-67) [cytosol]
(R-HSA-351223)
0.527
2
UniProt:Q9UHG2 PCS1N
0.527
2
UniProt:P54105 CLNS1A
1
CLNS1A [cytosol]
(R-HSA-191796)
0.527
2
UniProt:Q9H4B6 SAV1
2
SAV1 [cytosol]
(R-HSA-2028283)
p-SAV1 [cytosol]
(R-HSA-2028276)
0.527
2
UniProt:O95749 GGPS1
1
GGPS1 [cytosol]
(R-HSA-191415)
0.527
2
UniProt:Q9Y5J6 TIMM10B
1
4xHC-TIMM10B [mitochondrial inner membrane]
(R-HSA-1252043)
0.527
2
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.527
2
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