Reactome | DCTN2 [cytosol]

DCTN2 [cytosol]

Stable Identifier

R-HSA-380302

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynactin subunit 2, Dynamitin

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
    - HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
      - Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
      - Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - Kinesins:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPI-mediated anterograde transport (Homo sapiens)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
    - Golgi-to-ER retrograde transport (Homo sapiens)
      - COPI-independent Golgi-to-ER retrograde traffic (Homo sapiens)
        
        Dynein drives COPI-independent retrograde traffic from the Golgi to the ER (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        RAB6:GTP displaces PAFAH1B1 from dynein:dynactin complex (Homo sapiens)
        
        Dynein:Dynactin:microtubules:PAFAH1B1 [cytosol] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)
        
        RAB6:GTP:BICD dimer:COPI-independent retrograde cargo:Dynein:Dynactin:microtubules [Golgi membrane] (Homo sapiens)
        
        Dynein:Dynactin:microtubule [cytosol] (Homo sapiens)
        
        Dynactin [cytosol] (Homo sapiens)
        
        Dynactin arm [cytosol] (Homo sapiens)
        
        Dynactin shoulder [cytosol] (Homo sapiens)
        
        Dynamitin tetramer [cytosol] (Homo sapiens)
        
        DCTN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13561 DCTN2

Gene Names

DCTN2, DCTN50

Chain

initiator methionine:, chain:2-401

Reference Genes

BioGPS Gene:10540 DCTN2

COSMIC (genes):DCTN2 DCTN2

CTD Gene:10540 DCTN2

dbSNP Gene:10540 DCTN2

ENSEMBL:ENSG00000175203 DCTN2

HGNC:2712 DCTN2

KEGG:hsa:10540 DCTN2

Monarch:10540 DCTN2

NCBI Gene:10540 DCTN2

OMIM:607376 DCTN2

UCSC:Q13561 DCTN2

Reference Transcript

Other Identifiers

10540

11756957_a_at

11758722_at

16766590

200932_PM_s_at

200932_s_at

214384_PM_s_at

214384_s_at

3458615

3458616

3458617

3458618

3458619

3458620

3458621

3458622

3458623

3458624

3458625

3458626

3458627

3458628

3458629

3458630

3458631

3458632

3458633

3458634

3458635

3458636

3458637

3458638

3458639

3458640

3458641

3458642

3458643

3458646

3458647

3458648

3458649

3458650

3458651

3458652

3458653

3458654

3458655

3458656

3458657

3458658

3458659

3458660

3458661

38475_at

7964466

91437_at

A_23_P360167

A_23_P76059

GE59211

GO:0000776

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005869

GO:0005874

GO:0007010

GO:0007017

GO:0007052

GO:0007080

GO:0008092

GO:0016020

GO:0019901

GO:0030286

GO:0030426

GO:0030507

GO:0031982

GO:0032402

GO:0042802

GO:0043226

GO:0070062

GO:0071539

HMNXSV003047166

Hs.84153.3.A1_3p_at

ILMN_1662232

PH_hs_0023515

TC12001627.hg

U50733_at

g13259506_3p_a_at

Participates

as a component of

Inferred To

LOC100856399 [cytosol] (Canis familiaris)

dctn2 [cytosol] (Xenopus tropicalis)

dnc-2 [cytosol] (Caenorhabditis elegans)

Dctn2 [cytosol] (Mus musculus)

Dctn2 [cytosol] (Rattus norvegicus)

dynB [cytosol] (Dictyostelium discoideum)

DCTN2 [cytosol] (Bos taurus)

DCTN2 [cytosol] (Gallus gallus)

DCTN2 [cytosol] (Plasmodium falciparum)

DCTN2 [cytosol] (Sus scrofa)

DCTN2-p50 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_006391.1, NP_001248341.1, NP_001248342.1

ENSEMBL

ENST00000434715, ENST00000548249, ENST00000543672, ENSP00000447824, ENSP00000408910, ENSP00000439376

OpenTargets

ENSG00000175203

HPA

ENSG00000175203-DCTN2

PRO

Q13561

Pharos - Targets

Q13561

GlyGen

Q13561

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14203 DCTN1	7	DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711969) DCTN1(1-599)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711960) DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol] (R-HSA-9701997) DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711959) DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711953) DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711962) DCTN1 [cytosol] (R-HSA-535580)	0.779	9
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.742	7
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.725	6
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.725	5
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	12
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.643	5
UniProt:Q9UL45 BLOC1S6	1	BLOC1S6 [cytosol] (R-HSA-429816)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P78537 BLOC1S1	2	BLOC1S1 [Golgi membrane] (R-HSA-434324) BLOC1S1 [lysosomal membrane] (R-HSA-429821)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P59634 6	2	6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9705957) 6 [cytosol] (R-COV-9731048)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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