Reactome | DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711969

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynactin subunit 1, DCTN1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
24445538	Kinase fusions are frequent in Spitz tumours and spitzoid melanomas Wiesner, T, He, J, Yelensky, R, Esteve-Puig, R, Botton, T, Yeh, I, Lipson, D, Otto, G, Brennan, K, Murali, R, Garrido, M, Miller, VA, Ross, JS, Berger, MF, Sparatta, A, Palmedo, G, Cerroni, L, Busam, KJ, Kutzner, H, Cronin, MT, Stephens, PJ, Bastian, BC	Nat Commun	2014
25813404	Novel ALK fusion partners in lung cancer Iyevleva, AG, Raskin, GA, Tiurin, VI, Sokolenko, AP, Mitiushkina, NV, Aleksakhina, SN, Garifullina, AR, Strelkova, TN, Merkulov, VO, Ivantsov, AO, Kuligina, ESh, Pozharisski, KM, Togo, AV, Imyanitov, EN	Cancer Lett	2015

External Reference Information

External Reference

UniProt:Q14203 DCTN1

Gene Names

DCTN1

Chain

chain:1-1278

Reference Genes

BioGPS Gene:1639 DCTN1

COSMIC (genes):DCTN1 DCTN1

CTD Gene:1639 DCTN1

dbSNP Gene:1639 DCTN1

ENSEMBL:ENSG00000204843 DCTN1

HGNC:2711 DCTN1

KEGG:hsa:1639 DCTN1

Monarch:1639 DCTN1

NCBI Gene:1639 DCTN1

OMIM:601143 DCTN1

UCSC:Q14203 DCTN1

Reference Transcript

Participates

as a member of

ALK fusion proteins [cytosol] (Homo sapiens)

as a component of

DCTN1(1-1065)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

DCTN1 [cytosol]

DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 1066 from UniProt:Q9UM73 ALK

Coordinate

1066

Disease

Name	Identifier	Synonyms
malignant spindle cell melanoma	DOID:3162	spindle cell malignant melanoma, Spitzoid malignant melanoma, spindle cell melanoma, desmoplastic melanoma

Cross References

RefSeq

NP_075408.1, NP_004073.2, NP_001177766.1, NP_001177765.1, NP_001128513.1, NP_001128512.1

COSMIC

COSF1625

OpenTargets

ENSG00000204843

ENSEMBL

ENSP00000487724, ENST00000409438, ENST00000409567, ENST00000628224, ENSP00000387270, ENSP00000487279, ENSP00000377571, ENST00000394003, ENST00000409240, ENSG00000204843, ENSP00000386843, ENST00000633691, ENSP00000386406

Mondo

0006427

GeneCards

DCTN1

HPA

ENSG00000204843-DCTN1

PRO

Q14203

Pharos - Targets

Q14203

GlyGen

Q14203

Orphanet

DCTN1

PDB

1TXQ, 2HL3, 2HKN, 2COY, 2HQH, 2HKQ, 2HL5, 3E2U, 3TQ7

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.9	9
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.789	7
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.779	9
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.779	8
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.779	9
UniProt:P30622-1 CLIP1			0.76	7
UniProt:Q9NZ32 ACTR10	4	ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080) ACTR10 [cytosol] (R-HSA-6801556)	0.712	7
UniProt:O75935 DCTN3	1	DCTN3 [cytosol] (R-HSA-380264)	0.712	7
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.712	7
UniProt:P47755 CAPZA2	2	CAPZA2(265-276) [extracellular region] (R-HSA-879417) CAPZA2 [cytosol] (R-HSA-879448)	0.706	7
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.704	9
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [secretory granule lumen] (R-HSA-6801082)	0.65	6
UniProt:P54256 HAP1			0.646	4
UniProt:P52907 CAPZA1	2	CAPZA1 [cytosol] (R-HSA-879363) CAPZA1(265-276) [extracellular region] (R-HSA-879421)	0.638	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.635	3
UniProt:Q9BTE1 DCTN5	1	DCTN5 [cytosol] (R-HSA-2029012)	0.615	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	10
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.615	3
UniProt:P30622 CLIP1	3	CLIP1 [cytosol] (R-HSA-377732) CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane] (R-HSA-9842572) CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane] (R-HSA-9842573)	0.595	3
UniProt:O08788	1	Dctn1 [cytosol] (R-MMU-380301)	0.564	2
UniProt:Q99KJ8	1	Dctn2 [cytosol] (R-MMU-380302)	0.564	2
UniProt:Q9Z0Y1	1	Dctn3 [cytosol] (R-MMU-380264)	0.564	2
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:Q13409 DYNC1I2	1	DYNC1I2 [cytosol] (R-HSA-201607)	0.483	2
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.483	2
UniProt:Q7Z460 CLASP1	1	CLASP1 [cytosol] (R-HSA-376230)	0.483	3
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.48	2
UniProt:Q6DN90 IQEC1			0.471	2
UniProt:Q9JK25	1	Clip1 [cytosol] (R-RNO-377732)	0.463	2
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [ciliary tip] (R-HSA-5625333) DYNC2LI1 [cilium] (R-HSA-5624862)	0.462	2

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