Reactome | DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711969

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynactin subunit 1, DCTN1_HUMAN

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
24445538	Kinase fusions are frequent in Spitz tumours and spitzoid melanomas Palmedo, G, Botton, T, Yeh, I, Busam, KJ, Garrido, M, Cerroni, L, Bastian, BC, Murali, R, Wiesner, T, Kutzner, H, Ross, JS, Lipson, D, Cronin, MT, Berger, MF, He, J, Esteve-Puig, R, Stephens, PJ, Brennan, K, Miller, VA, Sparatta, A, Otto, G, Yelensky, R	Nat Commun	2014
25813404	Novel ALK fusion partners in lung cancer Pozharisski, KM, Aleksakhina, SN, Imyanitov, EN, Togo, AV, Sokolenko, AP, Ivantsov, AO, Mitiushkina, NV, Merkulov, VO, Strelkova, TN, Iyevleva, AG, Garifullina, AR, Tiurin, VI, Kuligina, ESh, Raskin, GA	Cancer Lett	2015

External Reference Information

External Reference

UniProt:Q14203 DCTN1

Gene Names

DCTN1

Chain

chain:1-1278

Reference Genes

BioGPS Gene:1639 DCTN1

COSMIC (genes):DCTN1 DCTN1

CTD Gene:1639 DCTN1

dbSNP Gene:1639 DCTN1

ENSEMBL:ENSG00000204843 DCTN1

ENSEMBL_homo_sapiens_GENE:ENSG00000204843.13 DCTN1

HGNC:2711 DCTN1

KEGG Gene (Homo sapiens):1639 DCTN1

Monarch:1639 DCTN1

NCBI Gene:1639 DCTN1

OMIM:601143 DCTN1

UCSC:Q14203 DCTN1

Reference Transcript

Other Identifiers

11715669_s_at

1639

16899150

201082_3p_s_at

201082_PM_s_at

201082_s_at

211780_3p_x_at

211780_PM_x_at

211780_x_at

2559966

2559968

2559969

2559970

2559971

2559972

2559973

2559975

2559976

2559978

2559979

2559980

2559983

2559987

2559989

2559991

2559993

2559994

2559995

2559996

2559997

2559998

2560000

2560001

2560002

2560003

2560004

2560005

2560007

2560010

2560013

2560014

2560020

2560021

2560022

2560024

2560025

2560026

2560027

2560030

36158_at

8053107

A_23_P142835

A_33_P3264577

GE60475

GO:0000132

GO:0000278

GO:0000776

GO:0000922

GO:0005515

GO:0005634

GO:0005635

GO:0005694

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005875

GO:0005929

GO:0005938

GO:0007010

GO:0007049

GO:0007097

GO:0007163

GO:0007399

GO:0007528

GO:0008017

GO:0008092

GO:0010457

GO:0015630

GO:0015631

GO:0016020

GO:0016192

GO:0019901

GO:0021517

GO:0030286

GO:0030424

GO:0030904

GO:0031116

GO:0031252

GO:0032402

GO:0032991

GO:0034330

GO:0034454

GO:0035371

GO:0036064

GO:0042147

GO:0043005

GO:0043025

GO:0043226

GO:0044782

GO:0045171

GO:0048156

GO:0048856

GO:0050877

GO:0050905

GO:0051081

GO:0051301

GO:0060236

GO:0061024

GO:0061744

GO:0065003

GO:0070050

GO:0072686

GO:0090063

GO:0099558

GO:0099738

GO:0120103

GO:1904398

GO:1905515

GO:1990535

ILMN_1793563

ILMN_2412807

PH_hs_0004258

PH_hs_0033522

TC02004342.hg

TC02004927.hg

X98801_at

g13259509_3p_s_at

g13544059_3p_s_at

Participates

as a member of

ALK fusion proteins [cytosol] (Homo sapiens)

as a component of

DCTN1(1-1065)-ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1 [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 1066 from UniProt:Q9UM73 ALK

Coordinate

1066

Disease

Name	Identifier	Synonyms
malignant spindle cell melanoma	DOID:3162	spindle cell malignant melanoma, Spitzoid malignant melanoma, spindle cell melanoma, desmoplastic melanoma

Cross References

RefSeq

NP_004073.2, NP_075408.1, NP_001128513.1, NP_001128512.1, NP_001177765.1, NP_001177766.1

COSMIC

COSF1625

OpenTargets

ENSG00000204843

GeneCards

Q14203

HPA

ENSG00000204843-DCTN1

Ensembl

ENSP00000386843, ENSG00000204843, ENST00000409438, ENSP00000386406, ENST00000633691, ENST00000409240, ENST00000628224, ENST00000409567, ENSP00000377571, ENSP00000487724, ENST00000394003, ENSP00000387270, ENSP00000487279

PRO

Q14203

Pharos - Targets

Q14203

Orphanet

16942

PDB

2COY, 3E2U, 2HQH, 2HL3, 2HL5, 2HKN, 1TXQ, 2HKQ, 3TQ7

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.9	9
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.779	9
UniProt:P30622-1 CLIP1			0.76	7
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.725	6
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.712	7
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.712	8
UniProt:O75935 DCTN3	1	DCTN3 [cytosol] (R-HSA-380264)	0.712	7
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.712	7
UniProt:Q9NZ32 ACTR10	4	ACTR10 [cytosol] (R-HSA-6801556) ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080)	0.712	7
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.704	9
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [secretory granule lumen] (R-HSA-6801082) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063)	0.65	6
UniProt:P54256 HAP1			0.646	4
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.638	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.635	3
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [extracellular region] (R-HSA-6806223) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [cytosol] (R-HSA-380285)	0.615	3
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.615	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	10
UniProt:P30622 CLIP1	3	CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane] (R-HSA-9842573) CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane] (R-HSA-9842572) CLIP1 [cytosol] (R-HSA-377732)	0.595	3
UniProt:Q9Z0Y1	1	Dctn3 [cytosol] (R-MMU-380264)	0.564	2
UniProt:Q99KJ8	1	Dctn2 [cytosol] (R-MMU-380302)	0.564	2
UniProt:O08788	1	Dctn1 [cytosol] (R-MMU-380301)	0.564	2
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:Q7Z460 CLASP1	1	CLASP1 [cytosol] (R-HSA-376230)	0.483	3
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.483	2
UniProt:Q13409 DYNC1I2	1	DYNC1I2 [cytosol] (R-HSA-201607)	0.483	2
UniProt:Q9BTE1 DCTN5	1	DCTN5 [cytosol] (R-HSA-2029012)	0.483	5
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.48	2
UniProt:Q6DN90 IQEC1			0.471	2
UniProt:Q9JK25	1	Clip1 [cytosol] (R-RNO-377732)	0.463	2
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [ciliary tip] (R-HSA-5625333) DYNC2LI1 [cilium] (R-HSA-5624862)	0.462	2

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