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PRKAR2A [ciliary base]
Stable Identifier
R-HSA-5610412
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary base
Synonyms
cAMP-dependent protein kinase type II-alpha regulatory chain
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
cAMP dissociates PKA, promoting GLI processing (Homo sapiens)
PKA regulatory subunits:cAMP [ciliary base] (Homo sapiens)
PKA regulatory subunits [ciliary base] (Homo sapiens)
PRKAR2A [ciliary base] (Homo sapiens)
PKA tetramer [ciliary base] (Homo sapiens)
PKA regulatory subunits [ciliary base] (Homo sapiens)
PRKAR2A [ciliary base] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13861 PRKAR2A
Gene Names
PRKAR2A, PKR2, PRKAR2
Chain
initiator methionine:, chain:2-404
Reference Genes
BioGPS Gene:5576 PRKAR2A
COSMIC (genes):PRKAR2A PRKAR2A
CTD Gene:5576 PRKAR2A
dbSNP Gene:5576 PRKAR2A
ENSEMBL:ENSG00000114302 PRKAR2A
HGNC:9391 PRKAR2A
KEGG:hsa:5576 PRKAR2A
Monarch:5576 PRKAR2A
NCBI Gene:5576 PRKAR2A
OMIM:176910 PRKAR2A
UCSC:P13861 PRKAR2A
Reference Transcript
RefSeq:NM_001321982.1 PRKAR2A
RefSeq:XM_017006815.1 PRKAR2A
RefSeq:NM_004157.3 PRKAR2A
RefSeq:NM_001321983.1 PRKAR2A
RefSeq:XM_011533942.2 PRKAR2A
Other Identifiers
116_at
11739647_a_at
11739648_a_at
11746478_a_at
11760103_at
11761290_x_at
16953735
204842_PM_x_at
204842_x_at
204843_PM_s_at
204843_s_at
213052_PM_at
213052_at
225000_PM_at
225000_at
225011_PM_at
225011_at
2673733
2673734
2673735
2673736
2673737
2673738
2673739
2673740
2673741
2673742
2673743
2673744
2673745
2673747
2673749
2673750
2673753
2673759
2673760
2673761
2673762
38905_at
46315_at
5576
65962_at
8087210
A_23_P22214
A_24_P943335
A_32_P142991
GE59721
GE79300
GO:0001932
GO:0003824
GO:0004862
GO:0005515
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005886
GO:0005925
GO:0005930
GO:0005952
GO:0007339
GO:0008603
GO:0016020
GO:0016301
GO:0016740
GO:0019904
GO:0030552
GO:0031588
GO:0031625
GO:0032991
GO:0034236
GO:0035556
GO:0043226
GO:0044853
GO:0070062
GO:0097546
GO:0098772
GO:0141162
HMNXSV003024942
HMNXSV003041145
Hs.286241.0.S1_3p_at
Hs.286241.0.S2_3p_at
Hs.289075.1.S1_3p_at
ILMN_1681888
PH_hs_0020943
TC03001389.hg
X14968_at
g12803842_3p_a_at
g4758957_3p_a_at
Participates
as a member of
PKA regulatory subunits [ciliary base] (Homo sapiens)
Other forms of this molecule
PRKAR2A [cytosol]
Inferred To
PRKAR2A [ciliary base]
(Bos taurus)
PRKAR2A [ciliary base]
(Canis familiaris)
PRKAR2A [ciliary base]
(Danio rerio)
PRKAR2A [ciliary base]
(Drosophila melanogaster)
PRKAR2A [ciliary base]
(Gallus gallus)
PRKAR2A [ciliary base]
(Mus musculus)
PRKAR2A [ciliary base]
(Rattus norvegicus)
PRKAR2A [ciliary base]
(Saccharomyces cerevisiae)
PRKAR2A [ciliary base]
(Schizosaccharomyces pombe)
PRKAR2A [ciliary base]
(Sus scrofa)
PRKAR2A [ciliary base]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001308911.1
,
NP_001308912.1
,
XP_016862304.1
,
XP_011532244.1
,
NP_004148.1
Guide to Pharmacology - Targets
1474
OpenTargets
ENSG00000114302
ENSEMBL
ENST00000296446
,
ENSP00000265563
,
ENSP00000394041
,
ENST00000706574
,
ENSP00000296446
,
ENST00000265563
,
ENST00000454963
,
ENSP00000516459
HPA
ENSG00000114302-PRKAR2A
PRO
P13861
Pharos - Targets
P13861
GlyGen
P13861
HMDB Protein
HMDBP08138
PDB
5XBY
,
4ZP3
,
5H78
,
2IZX
,
2KYG
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92667 AKAP1
2
AKAP1 [cytosol]
(R-HSA-992752)
AKAP1 [mitochondrial outer membrane]
(R-HSA-8951815)
0.813
8
UniProt:P24588 AKAP5
2
AKAP5 [plasma membrane]
(R-HSA-381669)
AKAP5 [cytosol]
(R-HSA-416331)
0.76
5
UniProt:P17612 PRKACA
4
PRKACA [cytosol]
(R-HSA-57844)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
0.759
4
UniProt:P03259-2
0.645
5
UniProt:P22694 PRKACB
3
PRKACB [ciliary base]
(R-HSA-5610404)
PRKACB [cytosol]
(R-HSA-57846)
PRKACB [nucleoplasm]
(R-HSA-111937)
0.643
4
UniProt:P31323 PRKAR2B
2
PRKAR2B [ciliary base]
(R-HSA-5610414)
PRKAR2B [cytosol]
(R-HSA-57842)
0.643
4
ChEBI:17489 3',5'-CYCLIC AMP
0.59
2
UniProt:O43823 AKAP8
0.571
3
UniProt:Q02952 AKAP12
1
AKAP12 [plasma membrane]
(R-HSA-9715082)
0.564
2
UniProt:P22612 PRKACG
3
PRKACG [ciliary base]
(R-HSA-5610405)
PRKACG [cytosol]
(R-HSA-57848)
PRKACG [nucleoplasm]
(R-HSA-111938)
0.527
2
UniProt:P0DTD1-PRO_0000449630 REP
0.527
2
UniProt:Q86UN6 AKA28
0.527
3
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.527
2
UniProt:P63167 DYNLL1
6
DYNLL1 [cytosol]
(R-HSA-387105)
DYNLL1 [plasma membrane]
(R-HSA-54017)
DYNLL1 [ficolin-1-rich granule membrane]
(R-HSA-6801518)
DYNLL1 [tertiary granule membrane]
(R-HSA-6801482)
DYNLL1 [cilium]
(R-HSA-5624863)
DYNLL1 [ciliary tip]
(R-HSA-5625335)
0.527
2
UniProt:O75969 AKAP3
0.508
2
ChEBI:64403 8-AHA-CAMP
0.499
6
ChEBI:64404 8-AHA-OMETHYLADENOSINE
0.499
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
UniProt:P38484 IFNGR2
1
IFNGR2 [plasma membrane]
(R-HSA-629620)
0.463
2
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