Reactome | PRKAR2A [cytosol]

PRKAR2A [cytosol]

Stable Identifier

R-HSA-57840

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cAMP-dependent protein kinase type II-alpha regulatory chain, RIIalpha

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)
      - cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - ROBO receptors bind AKAP5 (Homo sapiens)
        
        AKAP5 recruits PKA to ROBO2 (Homo sapiens)
        
        PRKAR2A-PKA type II [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)
        
        ROBO2:AKAP5:PRKAR2A-PKA type II [plasma membrane] (Homo sapiens)
        
        PRKAR2A-PKA type II [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Homo sapiens)
        
        cAMP binds PKA tetramer (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)
        
        cAMP induces dissociation of inactive PKA tetramers (Homo sapiens)
        
        PKA tetramer:4xcAMP [cytosol] (Homo sapiens)
        
        PKA tetramer [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)
        
        cAMP:PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PKA regulatory subunit [cytosol] (Homo sapiens)
        
        PRKAR2A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P13861 PRKAR2A

Gene Names

PRKAR2A, PKR2, PRKAR2

Chain

initiator methionine:, chain:2-404

Reference Genes

BioGPS Gene:5576 PRKAR2A

COSMIC (genes):PRKAR2A PRKAR2A

CTD Gene:5576 PRKAR2A

dbSNP Gene:5576 PRKAR2A

ENSEMBL:ENSG00000114302 PRKAR2A

HGNC:9391 PRKAR2A

KEGG:hsa:5576 PRKAR2A

Monarch:5576 PRKAR2A

NCBI Gene:5576 PRKAR2A

OMIM:176910 PRKAR2A

UCSC:P13861 PRKAR2A

Reference Transcript

Other Identifiers

116_at

11739647_a_at

11739648_a_at

11746478_a_at

11760103_at

11761290_x_at

16953735

204842_PM_x_at

204842_x_at

204843_PM_s_at

204843_s_at

213052_PM_at

213052_at

225000_PM_at

225000_at

225011_PM_at

225011_at

2673733

2673734

2673735

2673736

2673737

2673738

2673739

2673740

2673741

2673742

2673743

2673744

2673745

2673747

2673749

2673750

2673753

2673759

2673760

2673761

2673762

38905_at

46315_at

5576

65962_at

8087210

A_23_P22214

A_24_P943335

A_32_P142991

GE59721

GE79300

GO:0001932

GO:0003824

GO:0004862

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005886

GO:0005925

GO:0005930

GO:0005952

GO:0007339

GO:0008603

GO:0016020

GO:0016301

GO:0016740

GO:0019904

GO:0030552

GO:0031588

GO:0031625

GO:0032991

GO:0034236

GO:0035556

GO:0043226

GO:0044853

GO:0070062

GO:0097546

GO:0098772

GO:0141162

HMNXSV003024942

HMNXSV003041145

Hs.286241.0.S1_3p_at

Hs.286241.0.S2_3p_at

Hs.289075.1.S1_3p_at

ILMN_1681888

PH_hs_0020943

TC03001389.hg

X14968_at

g12803842_3p_a_at

g4758957_3p_a_at

Participates

as a component of

as an input of

NBEA binds PRKAR2A (Homo sapiens)

as a member of

PKA regulatory subunit [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAR2A [ciliary base]

Inferred To

PRKAR2A [cytosol] (Bos taurus)

PRKAR2A [cytosol] (Canis familiaris)

PRKAR2A [cytosol] (Danio rerio)

PRKAR2A [cytosol] (Drosophila melanogaster)

PRKAR2A [cytosol] (Gallus gallus)

PRKAR2A [cytosol] (Mus musculus)

PRKAR2A [cytosol] (Rattus norvegicus)

PRKAR2A [cytosol] (Saccharomyces cerevisiae)

PRKAR2A [cytosol] (Schizosaccharomyces pombe)

PRKAR2A [cytosol] (Sus scrofa)

PRKAR2A [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001308911.1, NP_001308912.1, XP_016862304.1, XP_011532244.1, NP_004148.1

Guide to Pharmacology - Targets

1474

OpenTargets

ENSG00000114302

ENSEMBL

ENST00000296446, ENSP00000265563, ENSP00000394041, ENST00000706574, ENSP00000296446, ENST00000265563, ENST00000454963, ENSP00000516459

HPA

ENSG00000114302-PRKAR2A

PRO

P13861

Pharos - Targets

P13861

GlyGen

P13861

HMDB Protein

HMDBP08138

PDB

5XBY, 4ZP3, 5H78, 2IZX, 2KYG

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92667 AKAP1	2	AKAP1 [cytosol] (R-HSA-992752) AKAP1 [mitochondrial outer membrane] (R-HSA-8951815)	0.813	8
UniProt:P24588 AKAP5	2	AKAP5 [plasma membrane] (R-HSA-381669) AKAP5 [cytosol] (R-HSA-416331)	0.76	5
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.759	4
UniProt:P03259-2			0.645	5
UniProt:P22694 PRKACB	3	PRKACB [ciliary base] (R-HSA-5610404) PRKACB [cytosol] (R-HSA-57846) PRKACB [nucleoplasm] (R-HSA-111937)	0.643	4
UniProt:P31323 PRKAR2B	2	PRKAR2B [ciliary base] (R-HSA-5610414) PRKAR2B [cytosol] (R-HSA-57842)	0.643	4
ChEBI:17489 3',5'-CYCLIC AMP			0.59	2
UniProt:O43823 AKAP8			0.571	3
UniProt:Q02952 AKAP12	1	AKAP12 [plasma membrane] (R-HSA-9715082)	0.564	2
UniProt:P22612 PRKACG	3	PRKACG [ciliary base] (R-HSA-5610405) PRKACG [cytosol] (R-HSA-57848) PRKACG [nucleoplasm] (R-HSA-111938)	0.527	2
UniProt:P0DTD1-PRO_0000449630 REP			0.527	2
UniProt:Q86UN6 AKA28			0.527	3
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:O75969 AKAP3			0.508	2
ChEBI:64403 8-AHA-CAMP			0.499	6
ChEBI:64404 8-AHA-OMETHYLADENOSINE			0.499	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:P38484 IFNGR2	1	IFNGR2 [plasma membrane] (R-HSA-629620)	0.463	2

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