Reactome | decanoyl-FASN [cytosol]

decanoyl-FASN [cytosol]

Stable Identifier

R-HSA-5655935

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

decanoyl-fatty acid synthase, decanoyl-FAS

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49327 FASN

Gene Names

FASN, FAS

Chain

chain:1-2511

Reference Genes

BioGPS Gene:2194 FASN

COSMIC (genes):FASN FASN

CTD Gene:2194 FASN

dbSNP Gene:2194 FASN

ENSEMBL:ENSG00000169710 FASN

ENSEMBL_homo_sapiens_GENE:ENSG00000169710.9 FASN

HGNC:3594 FASN

KEGG Gene (Homo sapiens):2194 FASN

Monarch:2194 FASN

NCBI Gene:2194 FASN

OMIM:600212 FASN

UCSC:P49327 FASN

Reference Transcript

Other Identifiers

11743314_a_at

16850107

212218_PM_s_at

212218_s_at

217006_PM_x_at

217006_x_at

2194

2802091

3774634

3774636

3774637

3774639

3774641

3774642

3774643

3774645

3774647

3774649

3774650

3774651

3774652

3774653

3774655

3774657

3774658

3774659

3774660

3774661

3774662

3774663

3774664

3774666

3774667

3774668

3774669

3774670

3774671

3774672

3774673

3774674

3774677

3774678

3774679

3774680

3774681

3774682

3774683

3774684

3774685

3774686

3774687

3774688

3774689

3774690

3774693

3774694

3774698

38429_at

8019392

A_23_P44132

A_33_P3329344

GE59061

GO:0001649

GO:0002068

GO:0003723

GO:0003824

GO:0004312

GO:0004313

GO:0004314

GO:0004315

GO:0004316

GO:0004317

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005794

GO:0005829

GO:0005886

GO:0006629

GO:0006631

GO:0006633

GO:0006954

GO:0008152

GO:0008610

GO:0008611

GO:0008659

GO:0008693

GO:0009058

GO:0009888

GO:0016020

GO:0016295

GO:0016296

GO:0016297

GO:0016419

GO:0016491

GO:0016740

GO:0016746

GO:0016787

GO:0016829

GO:0019171

GO:0030154

GO:0030223

GO:0030224

GO:0030879

GO:0031177

GO:0031410

GO:0042470

GO:0042587

GO:0043226

GO:0044788

GO:0045296

GO:0047117

GO:0047450

GO:0047451

GO:0048856

GO:0070062

GO:0071353

GO:0090557

HMNXSV003010470

Hs.11050.2.A2_3p_s_at

Hs.83190.1.S1_3p_a_at

ILMN_1784871

PH_hs_0004753

S80437_s_at

TC17001973.hg

Participates

as a component of

decanoyl-FASN dimer [cytosol] (Homo sapiens)

Other forms of this molecule

FASN [cytosol]

Modified Residues

Name

O-phosphopantetheine-L-serine (decanoyl group) at 2156

Coordinate

2156

Modification

decanoyl group

PsiMod Name

O-phosphopantetheine-L-serine [MOD:00159]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phosphopantetheine-L-serine.

Cross References

RefSeq

XP_011521840.1, NP_004095.4

ZINC - World Drugs

FAS_HUMAN

Guide to Pharmacology - Targets

2608

OpenTargets

ENSG00000169710

ZINC - FDA approved

FAS_HUMAN

ZINC - Substances

FAS_HUMAN

ZINC - Biogenic

FAS_HUMAN

ZINC target

P49327

PRO

P49327

PDB

2JFD, 3TJM, 8G7X, 6NNA, 1XKT, 4W82, 8EYI, 4W9N, 7MHD, 5C37, 2JFK, 3HHD, 4PIV, 8EYK, 7MHE, 2PX6, 8GKC, 4Z49, 2CG5

ZINC - Metabolites

FAS_HUMAN

GeneCards

P49327

HPA

ENSG00000169710-FASN

Ensembl

ENSG00000169710, ENST00000306749, ENSP00000304592

Pharos - Targets

P49327

ZINC - Predictions - Purchasable

FAS_HUMAN

HMDB Protein

HMDBP00035

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	11
UniProt:Q99IB8-PRO_0000045603			0.556	6
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.547	2
UniProt:Q8IV20 LACC1			0.539	8
UniProt:Q8N8N7 PTGR2	1	PTGR2 [cytosol] (R-HSA-8940670)	0.527	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.527	2
UniProt:Q16665 HIF1A	7	HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.463	4

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