Reactome | RPL7A [cytosol]

RPL7A [cytosol]

Stable Identifier

R-HSA-72488

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L7a, Surfeit locus protein 3, PLA-X polypeptide

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL7A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62424 RPL7A

Gene Names

RPL7A, SURF-3, SURF3

Chain

chain:1-266

Reference Genes

BioGPS Gene:6130 RPL7A

COSMIC (genes):RPL7A RPL7A

CTD Gene:6130 RPL7A

dbSNP Gene:6130 RPL7A

ENSEMBL:ENSG00000148303 RPL7A

HGNC:10364 RPL7A

KEGG:hsa:6130 RPL7A

Monarch:6130 RPL7A

NCBI Gene:6130 RPL7A

OMIM:185640 RPL7A

UCSC:P62424 RPL7A

Reference Transcript

RefSeq:NM_000972.2 RPL7A

Other Identifiers

11755604_x_at

17090740

17119726

17119728

17119730

17119732

217740_PM_x_at

217740_x_at

224930_PM_x_at

224930_x_at

234873_3p_x_at

234873_PM_x_at

234873_x_at

2638606

2728134

2782401

2782403

2782408

2782409

2782410

3192821

3192822

3192823

3192824

3192825

3192826

3192828

3192829

3192830

3192831

3192833

3192834

3192835

3192836

3192837

3192838

3192839

3192840

3192841

3192842

3192843

3192844

3192845

3192846

3192847

3192848

3192849

3192850

3192851

3192852

3192853

3291919

3291922

3291923

3291924

3291925

3450844

3481155

3570294

3570299

3805035

3937063

3937064

3937066

4050763

4050764

4050765

4050766

4050767

4050768

4050770

4050771

4050772

4050773

4050775

4050776

4050777

4050778

4050779

4050780

4050781

4050782

4050783

4050784

4050785

4050786

4050787

4050788

4050789

4050790

4050791

4050792

6130

8022972

8158998

8159004

8159006

A_21_P0000216

A_21_P0000217

A_21_P0000249

A_21_P0000250

A_23_P135084

GE79244

GO:0000470

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006396

GO:0006412

GO:0016020

GO:0022625

GO:0022626

GO:0042254

GO:0043226

GO:0045202

GO:0045296

GO:1990904

HMNXSV003001723

HMNXSV003017900

HMNXSV003030196

HMNXSV003038724

HMNXSV003058070

ILMN_1740749

ILMN_2135175

ILMN_2160160

M36072_at

PH_hs_0030120

PH_hs_0037400

RNA33694|snoRNA_scaRNA_290_75

RNA33724|snoRNA_scaRNA_320_72

RNA33732|snoRNA_scaRNA_328_71

RNA33768|snoRNA_scaRNA_364_68

TC09000772.hg

g4506660_3p_x_at

Participates

as a component of

Inferred To

rpl7a [cytosol] (Danio rerio)

rpl7a [cytosol] (Dictyostelium discoideum)

rpl7a [cytosol] (Xenopus tropicalis)

RPL7A [cytosol] (Bos taurus)

RPL7A [cytosol] (Canis familiaris)

RPL7A [cytosol] (Gallus gallus)

RPL7A [cytosol] (Plasmodium falciparum)

RPL7A [cytosol] (Sus scrofa)

Rpl7a [cytosol] (Mus musculus)

Rpl7a [cytosol] (Rattus norvegicus)

rpl-7A [cytosol] (Caenorhabditis elegans)

rpl8 [cytosol] (Schizosaccharomyces pombe)

RPL8B [cytosol] (Saccharomyces cerevisiae)

RpL7A [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000148303

ENSEMBL

ENSG00000148303, ENST00000323345, ENST00000630979, ENSP00000361076, ENSP00000487443, ENSG00000280858

HPA

ENSG00000148303-RPL7A

GeneCards

RPL7A

PRO

P62424

Pharos - Targets

P62424

GlyGen

P62424

PDB

6IP5, 8FKZ, 8G6J, 8FLB, 8FKT, 8XSX, 8FL6, 9G8M, 8QFD, 6Y0G, 7ZJX, 6LU8, 8G61, 8IPY, 8FL2, 8JDK, 8K2C, 6Y2L, 6XA1, 8Y0X, 6OLE, 8INK, 8IPX, 8OJ8, 8P2K, 9GMO, 6Z6N, 6IP6, 8FKQ, 8IR1, 8FLA, 8IFE, 7XNY, 5LKS, 8FKV, 4UG0, 8IR3, 8FKW, 8IDY, 8YOP, 8A3D, 8IPD, 8IDT, 6LQM, 8FL4, 7ZJW, 8FLC, 8G60, 6OLF, 8JDJ, 6OLI, 6LSS, 6Z6L, 8OHD, 8IFD, 8FLD, 8INE, 8FKR, 8XSZ, 8IE3, 8FL7, 8FKX, 8FKP, 6Y57, 6IP8, 6OLZ, 7QVP, 6ZM7, 6Y6X, 8Y0W, 5AJ0, 8JDM, 8G5Z, 8G5Y, 7A01, 8OJ0, 6ZMI, 7OW7, 6LSR, 5T2C, 7XNX, 8XSY, 8FLE, 6OM7, 8FKY, 8FKS, 8FKU, 8YOO, 8FL9, 7BHP, 8FLF, 8FL3, 8GLP, 4V6X, 6OLG, 6W6L, 6ZME, 8JDL, 6ZMO, 8INF, 6OM0, 6ZVK, 6Z6M, 6QZP, 8QOI, 7F5S, 8OJ5

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.564	3
UniProt:P62277 RPS13	2	RPS13 [cytosol] (R-HSA-72331) RPS13 [nucleoplasm] (R-HSA-6791198)	0.527	3
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	5
UniProt:P40429 RPL13A	2	RPL13A [cytosol] (R-HSA-72412) p-RPL13A [cytosol] (R-HSA-156829)	0.527	4
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.527	2
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	6
UniProt:Q9H6S0 YTHDC2	1	YTHDC2 [nucleoplasm] (R-HSA-9935827)	0.527	2
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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