Reactome | RPS3A [cytosol]

RPS3A [cytosol]

Stable Identifier

R-HSA-72373

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 3A, P49241, 40S ribosomal protein S3a

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Homo sapiens)
        
        40S ribosomal complex [cytosol] (Homo sapiens)
        
        RPS3A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61247 RPS3A

Gene Names

RPS3A, FTE1, MFTL

Chain

initiator methionine:, chain:2-264

Reference Genes

BioGPS Gene:6189 RPS3A

COSMIC (genes):RPS3A RPS3A

CTD Gene:6189 RPS3A

dbSNP Gene:6189 RPS3A

ENSEMBL:ENSG00000145425 RPS3A

HGNC:10421 RPS3A

KEGG:hsa:6189 RPS3A

Monarch:6189 RPS3A

NCBI Gene:6189 RPS3A

OMIM:180478 RPS3A

UCSC:P61247 RPS3A

Reference Transcript

RefSeq:NM_001006.4 RPS3A

Other Identifiers

11716320_x_at

11762787_x_at

1653_at

16652759

16652761

16652763

16652765

16652767

16652777

16971413

16971433

17119388

18670013

18670014

18670015

18670016

18670017

18670018

18670019

18670020

18670021

18670022

18670023

18670024

18670025

18670026

18670027

18670028

18670029

18670030

200099_PM_s_at

200099_s_at

201257_PM_x_at

201257_x_at

212391_PM_x_at

212391_x_at

2612273

2640149

2683221

2747386

2747387

2747388

2747389

2747390

2747391

2747392

2747394

2747395

2747396

2747397

2747398

2747399

2747400

2747401

2747402

2747403

2747404

2747405

2747406

2864020

2864032

2870769

2870772

3061872

3061877

3062954

3062956

3062958

3062959

3062962

3062963

3084158

3084759

3122846

3124697

3124911

3255508

3255510

3255512

3259229

3359842

3379154

3482604

3596234

3596235

3596236

3621007

3621014

3790794

3790796

3957133

6189

7894205

7894971

7894982

7988031

8097782

8097790

8097792

8103222

8141050

8141222

A_14_P201526

A_21_P0000207

A_23_P144497

GE79078

GE86759

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0006413

GO:0022626

GO:0022627

GO:0030154

GO:0032040

GO:0042274

GO:0043066

GO:0043226

GO:0045202

GO:0048027

GO:0070062

GO:1990904

HMNXSV003004860

HMNXSV003011773

HMNXSV003018368

Hs.77039.1.S1_3p_x_at

ILMN_1657722

ILMN_1667288

ILMN_1673638

ILMN_2139943

M84711_at

PH_hs_0029871

RNA33685|snoRNA_scaRNA_281_75

RNA33778|snoRNA_scaRNA_374_65

TC04000748.hg

TC04000749.hg

g4506722_3p_x_at

Participates

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS3A [nucleoplasm]

Inferred To

RpS3A [cytosol] (Drosophila melanogaster)

Ghost homologue of RPS3A [cytosol] (Gallus gallus)

rps-1 [cytosol] (Caenorhabditis elegans)

Rps3a [cytosol] (Mus musculus)

Rps3a [cytosol] (Rattus norvegicus)

RPS1B [cytosol] (Saccharomyces cerevisiae)

rps101 [cytosol] (Schizosaccharomyces pombe)

rps3a [cytosol] (Danio rerio)

rps3a [cytosol] (Dictyostelium discoideum)

rps3a [cytosol] (Xenopus tropicalis)

RPS3A [cytosol] (Bos taurus)

RPS3A [cytosol] (Canis familiaris)

RPS3A [cytosol] (Plasmodium falciparum)

RPS3A [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_000997.1

ENSEMBL

ENST00000709893, ENSP00000517921, ENST00000274065, ENSP00000346050

OpenTargets

ENSG00000145425

HPA

ENSG00000145425-RPS3A

PRO

P61247

Pharos - Targets

P61247

GlyGen

P61247

PDB

6ZOK, 6IP8, 8JDM, 8XXN, 4V6X, 6XA1, 8XXL, 8OZ0, 7WU0, 8G5Y, 5A2Q, 5T2C, 6ZXE, 5AJ0, 7WTS, 8G6J, 7WTZ, 7QVP, 6ZOJ, 6ZVJ, 8T4S, 5VYC, 7WTW, 7XNY, 8Y0X, 6YBW, 7A09, 6OM0, 6ZM7, 8PPL, 6IP5, 6YBD, 6OLE, 8G61, 8JDL, 7R4X, 6QZP, 6ZP4, 6ZME, 6G5H, 6ZXG, 6G18, 6ZMI, 6G4W, 7MQA, 8IFD, 6ZMO, 7XNX, 6Z6N, 6G53, 8G60, 8JDK, 8G5Z, 6FEC, 7QP7, 6IP6, 6OLF, 6ZXH, 6Y57, 8XXM, 7MQ9, 8GLP, 7TQL, 6G5I, 7MQ8, 5LKS, 7WTV, 7K5I, 7WTX, 6ZVH, 6OLZ, 7WTU, 6G4S, 6G51, 6ZN5, 6Z6L, 6ZLW, 6OLG, 6ZON, 5FLX, 7QP6, 8PPK, 8Y0W, 8JDJ, 6ZXF, 5OA3, 6Y2L, 6OLI, 6ZXD, 6ZUO, 6OM7, 6ZV6, 6ZMW, 6Y0G, 4UG0, 7WTT, 8QOI, 6ZMT, 6Z6M, 8IFE

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62263 RPS14	2	RPS14 [cytosol] (R-HSA-72333) RPS14 [nucleoplasm] (R-HSA-6790669)	0.669	4
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.635	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	9
UniProt:Q9NX58 LYAR			0.564	2
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.564	2
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	3
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:P62280 RPS11	2	RPS11 [cytosol] (R-HSA-72327) RPS11 [nucleoplasm] (R-HSA-6791212)	0.527	2
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	4
UniProt:Q96HE9 PRR11			0.527	2
UniProt:Q96ME7 ZN512			0.527	2
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:Q1ED39 KNOP1			0.527	2
UniProt:O95793 STAU1			0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:P17026 ZNF22			0.527	2
UniProt:Q15397 PUM3			0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:P42696 RBM34			0.527	2
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.495	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	4
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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