Reactome | AIP [nucleoplasm]

AIP [nucleoplasm]

Stable Identifier

R-HSA-8937156

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

AH receptor-interacting protein, AIP_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00170 AIP

Gene Names

AIP, aryl hydrocarbon receptor interacting protein, XAP2

Chain

chain:1-330

Reference Genes

BioGPS Gene:9049 AIP

COSMIC (genes):AIP AIP

CTD Gene:9049 AIP

dbSNP Gene:9049 AIP

ENSEMBL:ENSG00000110711 AIP

ENSEMBL_homo_sapiens_GENE:ENSG00000110711.11 AIP

HGNC:358 AIP

KEGG Gene (Homo sapiens):9049 AIP

Monarch:9049 AIP

NCBI Gene:9049 AIP

OMIM:605555 AIP

UCSC:O00170 AIP

Reference Transcript

Other Identifiers

11715980_at

16727908

201781_PM_s_at

201781_s_at

201782_PM_s_at

201782_s_at

3337140

3337141

3337142

3337145

3337147

3337149

3337150

3337152

3337153

36586_at

7941927

9049

GO:0003712

GO:0003713

GO:0003755

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006457

GO:0006626

GO:0006805

GO:0006886

GO:0007005

GO:0010738

GO:0016020

GO:0016853

GO:0017162

GO:0022417

GO:0023052

GO:0034751

GO:0036004

GO:0043226

GO:0045893

GO:0051082

GO:0051604

GO:0140096

GO:0140110

HMNXSV003056212

Hs.75305.0.S1_3p_a_at

ILMN_2103841

PH_hs_0024902

PH_hs_0035930

TC11000693.hg

U78521_at

Participates

as a component of

Other forms of this molecule

AIP [cytosol]

Inferred To

Aip [nucleoplasm] (Mus musculus)

Aip [nucleoplasm] (Rattus norvegicus)

Dmel\CG1847 [nucleoplasm] (Drosophila melanogaster)

aipr-1 [nucleoplasm] (Caenorhabditis elegans)

AIP [nucleoplasm] (Bos taurus)

AIP [nucleoplasm] (Canis familiaris)

AIP [nucleoplasm] (Dictyostelium discoideum)

AIP [nucleoplasm] (Gallus gallus)

AIP [nucleoplasm] (Plasmodium falciparum)

AIP [nucleoplasm] (Sus scrofa)

aip [nucleoplasm] (Danio rerio)

aip [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001289888.1, NP_001289889.1, NP_003968.3

OpenTargets

ENSG00000110711

HPA

ENSG00000110711-AIP

GeneCards

O00170

Ensembl

ENSP00000279146, ENSG00000110711, ENST00000279146

PRO

O00170

Pharos - Targets

O00170

Orphanet

18425

PDB

4APO, 8QMO, 7ZUB, 2LKN, 4AIF

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.829	8
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.643	5
UniProt:O00408 PDE2A	1	PDE2A [cytosol] (R-HSA-418499)	0.602	6
UniProt:P68400 CSNK2A1	2	CSNK2A1 [nucleoplasm] (R-HSA-6805057) CSNK2A1 [cytosol] (R-HSA-201713)	0.59	2
UniProt:O60809 PRA10			0.589	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q6PHR2 ULK3	1	ULK3 [ciliary tip] (R-HSA-5635039)	0.527	2
UniProt:P13385 TDGF1	1	N-aspartyl-glycosylphosphatidylinositolethanolamine-TDGF1(31-188) [plasma membrane] (R-HSA-452300)	0.527	3
UniProt:Q96HB5 CC120			0.527	4
UniProt:Q5VTA0 PRA17			0.527	2
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.527	2
UniProt:Q0VAF6 SYCN			0.499	2
UniProt:Q92985 IRF7	5	K63polyUb-IRF7 [endosome membrane] (R-HSA-975154) IRF7 [endosome membrane] (R-HSA-450274) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) IRF7 [cytosol] (R-HSA-450281)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8
UniProt:P35869 AHR	2	AHR [cytosol] (R-HSA-8936842) AHR [nucleoplasm] (R-HSA-8937190)	0.463	3

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