Reactome | PPP1CB A56P [cytosol]

PPP1CB A56P [cytosol]

Stable Identifier

R-HSA-9660543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP1CB, Serine/threonine protein phosphatase PP1-beta catalytic subunit , PP-1B

Icon

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Signaling by MRAS-complex mutants (Homo sapiens)
      - Gain-of-function MRAS complexes activate RAF signaling (Homo sapiens)
        
        Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
        
        mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
        
        S-GCC MRAS:GTP:SHOC2:PP1 mutants [plasma membrane] (Homo sapiens)
        
        PPP1CB mutants [cytosol] (Homo sapiens)
        
        PPP1CB A56P [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62140 PPP1CB

Gene Names

PPP1CB

Chain

initiator methionine:, chain:2-327

Reference Genes

BioGPS Gene:5500 PPP1CB

COSMIC (genes):PPP1CB PPP1CB

CTD Gene:5500 PPP1CB

dbSNP Gene:5500 PPP1CB

ENSEMBL:ENSG00000213639 PPP1CB

HGNC:9282 PPP1CB

KEGG:hsa:5500 PPP1CB

Monarch:5500 PPP1CB

NCBI Gene:5500 PPP1CB

OMIM:600590 PPP1CB

UCSC:P62140 PPP1CB

Reference Transcript

Other Identifiers

11725614_s_at

11725615_a_at

11725616_at

11746720_a_at

11757308_s_at

16878522

16878541

201407_PM_s_at

201407_s_at

201408_PM_at

201408_at

201409_PM_s_at

201409_s_at

2475210

2475211

2475212

2475213

2475214

2475216

2475226

2475227

2475228

2475232

2475233

2475234

2475235

2475237

2475241

2475242

2475244

2475245

2475246

2475247

2475248

2475249

2475250

2475251

5500

68234_r_at

78737_at

8041122

A_14_P125869

A_24_P396720

A_24_P405298

GE60066

GO:0000165

GO:0000781

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005925

GO:0005975

GO:0005977

GO:0006091

GO:0006470

GO:0016787

GO:0016791

GO:0017018

GO:0019901

GO:0030155

GO:0032922

GO:0042752

GO:0043153

GO:0043226

GO:0046872

GO:0048511

GO:0050115

GO:0051301

GO:0070062

GO:0072357

GO:0140096

HMNXSV003012482

Hs.21537.0.S2_3p_a_at

Hs.21537.0.S4_3p_s_at

ILMN_2405018

ILMN_2405023

PH_hs_0001870

TC02004955.hg

X80910_at

g4506004_3p_a_at

Participates

as a member of

PPP1CB mutants [cytosol] (Homo sapiens)

Other forms of this molecule

PPP1CB [cytosol]

PPP1CB P49R [cytosol]

PPP1CB [nucleoplasm]

Modified Residues

Name

L-alanine 56 replaced with L-proline

Coordinate

PsiMod

L-alanine removal [MOD:01631]

A protein modification that effectively removes or replaces an L-alanine.

L-proline residue [MOD:00024]

A protein modification that effectively converts a source amino acid residue to L-proline.

Disease

Name	Identifier	Synonyms
Noonan syndrome	DOID:3490	Turner's phenotype, karyotype normal (disorder)

Cross References

RefSeq

NP_002700.1, NP_996759.1

ClinGen

CA346581171

ENSEMBL

ENST00000703173, ENSP00000398839, ENSP00000296122, ENSP00000515219, ENST00000395366, ENSP00000378769, ENSP00000414918, ENST00000441461, ENST00000296122, ENST00000420282

OpenTargets

ENSG00000213639

IntEnz

3.1.3.53

HPA

ENSG00000213639-PPP1CB

PRO

P62140

Pharos - Targets

P62140

GlyGen

P62140

Orphanet

PPP1CB

HMDB Protein

HMDBP01775

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.902	8
UniProt:Q12972 PPP1R8	1	PPP1R8 [nucleoplasm] (R-HSA-9770253)	0.816	6
UniProt:Q9UQK1 PPP1R3C	2	K48polyUb-PPP1R3C [cytosol] (R-HSA-3781005) PPP1R3C [cytosol] (R-HSA-3777102)	0.782	9
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.725	4
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.676	4
UniProt:Q6UXN9 WDR82	1	WDR82 [nucleoplasm] (R-HSA-9821474)	0.671	4
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.581	3
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.569	3
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583)	0.556	3
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.527	4
UniProt:Q8NI77 KIF18A	1	KIF18A [cytosol] (R-HSA-376239)	0.508	2
UniProt:O08785 Clock	2	p-S-Clock [nucleoplasm] (R-MMU-508670) Clock [cytosol] (R-MMU-508720)	0.508	2
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.508	2
UniProt:O60828 PQBP1	1	PQBP1 [nucleoplasm] (R-HSA-8867889)	0.508	2
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.508	2
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.508	2
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.463	2

Cite Us!