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MKRN1 [cytosol]
Stable Identifier
R-HSA-976042
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase makorin-1, MKRN1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates MKRN1 (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
AKT phosphorylates MKRN1 (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHC7 MKRN1
Gene Names
MKRN1, RNF61
Chain
chain:1-482
Reference Genes
BioGPS Gene:23608 MKRN1
COSMIC (genes):MKRN1 MKRN1
CTD Gene:23608 MKRN1
dbSNP Gene:23608 MKRN1
ENSEMBL:ENSG00000133606 MKRN1
HGNC:7112 MKRN1
KEGG:hsa:23608 MKRN1
Monarch:23608 MKRN1
NCBI Gene:23608 MKRN1
OMIM:607754 MKRN1
UCSC:Q9UHC7 MKRN1
Reference Transcript
RefSeq:NM_013446.3 MKRN1
RefSeq:XM_011515997.2 MKRN1
RefSeq:NM_001145125.1 MKRN1
RefSeq:XM_011515998.1 MKRN1
Other Identifiers
11718558_s_at
11728691_a_at
11745175_a_at
11751335_a_at
11751336_x_at
11754758_a_at
11757664_s_at
201285_PM_at
201285_at
209845_PM_at
209845_at
23608
3076176
3076177
3076179
3076180
3076181
3076183
3076184
3076185
3076186
3076187
3076188
3076189
3076190
3076191
3076192
3076193
3076194
3076199
3076200
3076201
3076202
3076208
3076209
3076210
3076211
3076212
3076213
3076214
3076215
3076216
3181086
3464558
37650_at
3974622
3983622
4028786
51678_at
8143387
A_23_P59798
A_24_P29703
A_24_P410627
GE58538
GE61600
GO:0000209
GO:0003723
GO:0003824
GO:0005515
GO:0005575
GO:0005829
GO:0016567
GO:0016740
GO:0046872
GO:0061630
GO:0140096
HMNXSV003005987
HMNXSV003013462
ILMN_1671583
PH_hs_0000807
g6563239_3p_at
g7305272_3p_at
Participates
as an input of
AKT phosphorylates MKRN1 (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Other forms of this molecule
p-S109-MKRN1 [cytosol]
Inferred To
lep-2 [cytosol]
(Caenorhabditis elegans)
Mkrn1 [cytosol]
(Drosophila melanogaster)
Mkrn1 [cytosol]
(Mus musculus)
Mkrn1 [cytosol]
(Rattus norvegicus)
MKRN1 [cytosol]
(Bos taurus)
MKRN1 [cytosol]
(Canis familiaris)
MKRN1 [cytosol]
(Dictyostelium discoideum)
MKRN1 [cytosol]
(Gallus gallus)
MKRN1 [cytosol]
(Sus scrofa)
cps3 [cytosol]
(Schizosaccharomyces pombe)
mkrn1 [cytosol]
(Danio rerio)
mkrn1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011514300.1
,
NP_038474.2
,
XP_011514299.1
,
NP_001138597.1
ENSEMBL
ENST00000255977
,
ENST00000443720
,
ENSP00000255977
,
ENST00000474576
,
ENSP00000417863
,
ENSP00000416369
OpenTargets
ENSG00000133606
HPA
ENSG00000133606-MKRN1
PRO
Q9UHC7
Pharos - Targets
Q9UHC7
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.602
8
UniProt:P41227 NAA10
0.556
5
UniProt:Q96DC9 OTUB2
2
OTUB2 [cytosol]
(R-HSA-933410)
OTUB2 [nucleoplasm]
(R-HSA-6783260)
0.556
3
UniProt:Q3B820 F161A
0.556
3
UniProt:P57075-2 UBASH3A
0.556
3
UniProt:P54727 RAD23B
2
RAD23B [cytosol]
(R-HSA-8850589)
RAD23B [nucleoplasm]
(R-HSA-62590)
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
5
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:Q9Y2X8 UBE2D4
1
UBE2D4 [cytosol]
(R-HSA-947623)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.556
3
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.556
3
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
5
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
UniProt:P38936 CDKN1A
5
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
CDKN1A [cytosol]
(R-HSA-182512)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.524
5
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