Reactome | MKRN1 [cytosol]

MKRN1 [cytosol]

Stable Identifier

R-HSA-976042

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase makorin-1, MKRN1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UHC7 MKRN1

Gene Names

MKRN1, RNF61

Chain

chain:1-482

Reference Genes

BioGPS Gene:23608 MKRN1

COSMIC (genes):MKRN1 MKRN1

CTD Gene:23608 MKRN1

dbSNP Gene:23608 MKRN1

ENSEMBL:ENSG00000133606 MKRN1

HGNC:7112 MKRN1

KEGG Gene (Homo sapiens):23608 MKRN1

Monarch:23608 MKRN1

NCBI Gene:23608 MKRN1

OMIM:607754 MKRN1

UCSC:Q9UHC7 MKRN1

Reference Transcript

Other Identifiers

0000060575

11718558_s_at

11728691_a_at

11745175_a_at

11751335_a_at

11751336_x_at

11754758_a_at

11757664_s_at

201285_at

209845_at

23608

3076176

3076177

3076179

3076180

3076181

3076183

3076185

3076186

3076187

3076188

3076189

3076191

3076192

3076194

3076199

3076200

3076213

3076214

3076215

3076216

3181086

3464558

37650_at

3974622

3983622

4028786

51678_at

8143387

A_23_P59798

A_24_P29703

A_24_P410627

GE58538

GE61600

GO:0000209

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006464

GO:0008150

GO:0016567

GO:0016740

GO:0043167

GO:0046872

GO:0061630

ILMN_1671583

PH_hs_0000807

g6563239_3p_at

g7305272_3p_at

Participant Of

hasCandidate

E3 ligases in proteasomal degradation [cytosol]

input

AKT phosphorylates MKRN1

Other forms of this molecule

p-S109-MKRN1 [cytosol]

Inferred To

Dmel\CG5347 [cytosol] (Drosophila melanogaster)

lep-2 [cytosol] (Caenorhabditis elegans)

Dmel\CG5334 [cytosol] (Drosophila melanogaster)

Mkrn1 [cytosol] (Drosophila melanogaster)

Mkrn1 [cytosol] (Mus musculus)

Mkrn1 [cytosol] (Rattus norvegicus)

Dmel\CG12477 [cytosol] (Drosophila melanogaster)

MKRN1 [cytosol] (Bos taurus)

MKRN1 [cytosol] (Canis familiaris)

MKRN1 [cytosol] (Dictyostelium discoideum)

MKRN1 [cytosol] (Gallus gallus)

MKRN1 [cytosol] (Schizosaccharomyces pombe)

MKRN1 [cytosol] (Sus scrofa)

kdm5a [cytosol] (Xenopus tropicalis)

cps3 [cytosol] (Schizosaccharomyces pombe)

DMAC2 [cytosol] (Sus scrofa)

Homologues of MKRN1 [cytosol] (Canis familiaris)

Homologues of MKRN1 [cytosol] (Dictyostelium discoideum)

Homologues of MKRN1 [cytosol] (Drosophila melanogaster)

Homologues of MKRN1 [cytosol] (Schizosaccharomyces pombe)

Homologues of MKRN1 [cytosol] (Sus scrofa)

mkrn1 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_038474.2, XP_011514300.1, XP_011514299.1, NP_001138597.1

OpenTargets

ENSG00000133606

HPA

ENSG00000133606-MKRN1

GeneCards

Q9UHC7

Ensembl

ENST00000443720, ENST00000255977, ENSG00000133606, ENSP00000416369, ENST00000474576, ENSP00000417863, ENSP00000255977

PRO

Q9UHC7

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.602	8
UniProt:P41227 NAA10			0.556	5
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	5
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.556	3
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.556	3
UniProt:P51668 UBE2D1	3	UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) UBE2D1 [cytosol] (R-HSA-174236)	0.556	3
UniProt:Q8N3F0 MTURN			0.556	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.556	5
UniProt:P54727 RAD23B	2	RAD23B [cytosol] (R-HSA-8850589) RAD23B [nucleoplasm] (R-HSA-62590)	0.556	3
UniProt:P57075-2 UBASH3A			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q96DC9 OTUB2	2	OTUB2 [cytosol] (R-HSA-933410) OTUB2 [nucleoplasm] (R-HSA-6783260)	0.556	3
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585)	0.524	5

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