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MKRN1 [cytosol]
Stable Identifier
R-HSA-976042
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase makorin-1, MKRN1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the cytosol (Homo sapiens)
AKT phosphorylates MKRN1 (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
AKT phosphorylates MKRN1 (Homo sapiens)
MKRN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHC7 MKRN1
Gene Names
MKRN1, RNF61
Chain
chain:1-482
Reference Genes
BioGPS Gene:23608 MKRN1
COSMIC (genes):MKRN1 MKRN1
CTD Gene:23608 MKRN1
dbSNP Gene:23608 MKRN1
ENSEMBL:ENSG00000133606 MKRN1
HGNC:7112 MKRN1
KEGG Gene (Homo sapiens):23608 MKRN1
Monarch:23608 MKRN1
NCBI Gene:23608 MKRN1
OMIM:607754 MKRN1
UCSC:Q9UHC7 MKRN1
Reference Transcript
RefSeq:XM_011515998.1 MKRN1
RefSeq:XM_011515997.2 MKRN1
RefSeq:NM_001145125.1 MKRN1
RefSeq:NM_013446.3 MKRN1
Other Identifiers
0000060575
11718558_s_at
11728691_a_at
11745175_a_at
11751335_a_at
11751336_x_at
11754758_a_at
11757664_s_at
201285_at
209845_at
23608
3076176
3076177
3076179
3076180
3076181
3076183
3076185
3076186
3076187
3076188
3076189
3076191
3076192
3076194
3076199
3076200
3076213
3076214
3076215
3076216
3181086
3464558
37650_at
3974622
3983622
4028786
51678_at
8143387
A_23_P59798
A_24_P29703
A_24_P410627
GE58538
GE61600
GO:0000209
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006464
GO:0008150
GO:0016567
GO:0016740
GO:0043167
GO:0046872
GO:0061630
ILMN_1671583
PH_hs_0000807
g6563239_3p_at
g7305272_3p_at
Participant Of
hasCandidate
E3 ligases in proteasomal degradation [cytosol]
input
AKT phosphorylates MKRN1
Other forms of this molecule
p-S109-MKRN1 [cytosol]
Inferred To
Dmel\CG5347 [cytosol] (Drosophila melanogaster)
lep-2 [cytosol] (Caenorhabditis elegans)
Dmel\CG5334 [cytosol] (Drosophila melanogaster)
Mkrn1 [cytosol] (Drosophila melanogaster)
Mkrn1 [cytosol] (Mus musculus)
Mkrn1 [cytosol] (Rattus norvegicus)
Dmel\CG12477 [cytosol] (Drosophila melanogaster)
MKRN1 [cytosol] (Bos taurus)
MKRN1 [cytosol] (Canis familiaris)
MKRN1 [cytosol] (Dictyostelium discoideum)
MKRN1 [cytosol] (Gallus gallus)
MKRN1 [cytosol] (Schizosaccharomyces pombe)
MKRN1 [cytosol] (Sus scrofa)
cps3 [cytosol] (Schizosaccharomyces pombe)
DMAC2 [cytosol] (Sus scrofa)
Homologues of MKRN1 [cytosol] (Bos taurus)
Homologues of MKRN1 [cytosol] (Canis familiaris)
Homologues of MKRN1 [cytosol] (Dictyostelium discoideum)
Homologues of MKRN1 [cytosol] (Drosophila melanogaster)
Homologues of MKRN1 [cytosol] (Schizosaccharomyces pombe)
Homologues of MKRN1 [cytosol] (Sus scrofa)
mkrn1 [cytosol] (Danio rerio)
mkrn1 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_038474.2
,
XP_011514300.1
,
NP_001138597.1
,
XP_011514299.1
OpenTargets
ENSG00000133606
GeneCards
Q9UHC7
HPA
ENSG00000133606-MKRN1
Ensembl
ENST00000474576
,
ENSP00000255977
,
ENSG00000133606
,
ENST00000443720
,
ENSP00000417863
,
ENST00000255977
,
ENSP00000416369
PRO
Q9UHC7
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.602
8
UniProt:Q13895 BYSL
2
BYSL [cytosol]
(R-HSA-6791518)
BYSL [nucleoplasm]
(R-HSA-6791526)
0.556
3
UniProt:Q9UER7 DAXX
2
DAXX [nucleoplasm]
(R-HSA-3222068)
SUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.556
3
UniProt:Q9Y2X8 UBE2D4
1
UBE2D4 [cytosol]
(R-HSA-947623)
0.556
3
UniProt:P51668 UBE2D1
3
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
UBE2D1 [cytosol]
(R-HSA-174236)
0.556
3
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
5
UniProt:Q5VVQ6 YOD1
1
YOD1 [cytosol]
(R-HSA-6781909)
0.556
5
UniProt:P54727 RAD23B
2
RAD23B [cytosol]
(R-HSA-8850589)
RAD23B [nucleoplasm]
(R-HSA-62590)
0.556
3
UniProt:P57075-2 UBASH3A
0.556
3
UniProt:Q3B820 F161A
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
0.556
3
UniProt:Q96DC9 OTUB2
2
OTUB2 [cytosol]
(R-HSA-933410)
OTUB2 [nucleoplasm]
(R-HSA-6783260)
0.556
3
UniProt:P41227 NAA10
0.556
5
UniProt:P38936 CDKN1A
5
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
0.524
5
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