Reactome | MKRN1 [cytosol]

MKRN1 [cytosol]

Stable Identifier

R-HSA-976042

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase makorin-1, MKRN1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UHC7 MKRN1

Gene Names

MKRN1, RNF61

Chain

chain:1-482

Reference Genes

BioGPS Gene:23608 MKRN1

COSMIC (genes):MKRN1 MKRN1

CTD Gene:23608 MKRN1

dbSNP Gene:23608 MKRN1

ENSEMBL:ENSG00000133606 MKRN1

HGNC:7112 MKRN1

KEGG Gene (Homo sapiens):23608 MKRN1

Monarch:23608 MKRN1

NCBI Gene:23608 MKRN1

OMIM:607754 MKRN1

UCSC:Q9UHC7 MKRN1

Reference Transcript

Other Identifiers

0000060575

11718558_s_at

11728691_a_at

11745175_a_at

11751335_a_at

11751336_x_at

11754758_a_at

11757664_s_at

201285_at

209845_at

23608

3076176

3076177

3076179

3076180

3076181

3076183

3076185

3076186

3076187

3076188

3076189

3076191

3076192

3076194

3076199

3076200

3076213

3076214

3076215

3076216

3181086

3464558

37650_at

3974622

3983622

4028786

51678_at

567

8143387

A_23_P59798

A_24_P29703

A_24_P410627

AAF17214

AAF17487

AAF18979

AAH25955

AAH37400

AAH64838

AB209298

AC069335

AF117233

AF192784

AF192789

AF192790

AF192791

AF192792

AF192793

AK127030

AK315552

AL136812

AM236048

BAD92535

BAG37929

BAG54426

BC025955

BC037400

BC064838

C9IY57

C9IZP5

C9J031

C9JYI0

C9JYX8

CAB66746

CAJ84705

CCDS47725

CCDS5860

CH236950

CH471070

EAL24026

EAW83949

ENSG00000133606

ENSP00000255977

ENSP00000416369

ENSP00000417863

ENST00000255977

ENST00000255977.6

ENST00000443720

ENST00000443720.6

ENST00000474576

ENST00000474576.5

EntrezGene:23608

EntrezGene:MKRN1

F8WAS8

F8WBJ4

F8WEY8

g6563239_3p_at

g7305272_3p_at

GE58538

GE61600

GO:0000209

GO:0003674

GO:0003723

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0006464

GO:0008150

GO:0016567

GO:0016740

GO:0043167

GO:0046872

GO:0061630

H7C4H5

H7C588

HGNC:7112

HPA000567

ILMN_1671583

IPR000571

IPR001841

IPR013083

IPR017907

IPR018957

IPR031644

IPR036855

IPR041367

MIM:607754

MKRN1

MKRN1-201

MKRN1-202

MKRN1-208

NM_001145125

NM_001291663

NM_013446

NP_001138597

NP_001278592

NP_038474

PF00097

PF15815

PF18044

PH_hs_0000807

SM00184

SM00356

UPI0000001C5F

UPI0000141757

UPI0001B79267

XM_011515996

XM_011515997

XM_011515998

XP_011514298

XP_011514299

XP_011514300

Participant Of

hasCandidate

E3 ligases in proteasomal degradation [cytosol]

input

AKT phosphorylates MKRN1

Other forms of this molecule

p-S109-MKRN1 [cytosol]

Inferred To

MKRN1 [cytosol] (Bos taurus)

MKRN1 [cytosol] (Caenorhabditis elegans)

MKRN1 [cytosol] (Canis familiaris)

MKRN1 [cytosol] (Danio rerio)

MKRN1 [cytosol] (Dictyostelium discoideum)

MKRN1 [cytosol] (Drosophila melanogaster)

MKRN1 [cytosol] (Gallus gallus)

MKRN1 [cytosol] (Mus musculus)

MKRN1 [cytosol] (Rattus norvegicus)

MKRN1 [cytosol] (Sus scrofa)

MKRN1 [cytosol] (Xenopus tropicalis)

Homologues of MKRN1 [cytosol] (Bos taurus)

Homologues of MKRN1 [cytosol] (Canis familiaris)

Homologues of MKRN1 [cytosol] (Dictyostelium discoideum)

Homologues of MKRN1 [cytosol] (Drosophila melanogaster)

Homologues of MKRN1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_038474.2, NP_001138597.1, XP_011514299.1, XP_011514300.1

OpenTargets

ENSG00000133606

GeneCards

Q9UHC7

PRO

Q9UHC7

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.602	8
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.524	5
UniProt:P41227 NAA10			0.488	2
UniProt:Q96DC9 OTUB2	2	OTUB2 [nucleoplasm] (R-HSA-6783260) OTUB2 [cytosol] (R-HSA-933410)	0.488	2
UniProt:Q3B820 F161A			0.488	2
UniProt:P57075-2 UBASH3A			0.488	2
UniProt:P54727 RAD23B	2	RAD23B [nucleoplasm] (R-HSA-62590) RAD23B [cytosol] (R-HSA-8850589)	0.488	2
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.488	2
UniProt:Q8N3F0 MTURN			0.488	2
UniProt:P51668 UBE2D1	3	UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160) UBE2D1 [cytosol] (R-HSA-174236)	0.488	2
UniProt:Q9Y2X8 UBE2D4	1	UBE2D4 [cytosol] (R-HSA-947623)	0.488	2
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.488	2
UniProt:Q9UER7 DAXX	2	DAXX [nucleoplasm] (R-HSA-3222068) SUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.488	2
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.488	2
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.488	2