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UBE2D1 [cytosol]
Stable Identifier
R-HSA-174236
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UbcH5/Ubc4
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Association of Securin with Cdc20:APC/C complex (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
Association of cell cycle proteins with the APC/C:Cdh1 complex (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated cell cycle proteins (Homo sapiens)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Homo sapiens)
cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of Cyclin B (Homo sapiens)
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated Cyclin B (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Homo sapiens)
Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin (Homo sapiens)
Association of Securin with Cdc20:APC/C complex (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated Securin (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:p-APC/C:PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
Association of Nek2A with MCC:APC/C (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Degradation of multiubiquitinated Nek2A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Multiubiquitination of Nek2A (Homo sapiens)
Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
Association of Cyclin A with the APC/C (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Degradation multiubiquitinated Cyclin A (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
Association of Cdh1 with the APC/C (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Dissociation of Cdc20 from APC/C complex (Homo sapiens)
CDC20:p-APC/C [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Binding of the MCC complex to the APC/C complex (Homo sapiens)
MCC:APC/C complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
CDK-mediated phosphorylation and removal of Cdc6 (Homo sapiens)
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Homo sapiens)
phospho-APC/C:Cdh1 complex [cytosol] (Homo sapiens)
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Transfer of ubiquitin from E1 to E2 (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Ubiquitin:E2 conjugating enzymes [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
UBE2D2,UBE2D1,(CDC34) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
UBE2D2,UBE2D1,(CDC34) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DDX41 ubiquitination by TRIM21 (Homo sapiens)
UBE2D1/2/3/4:ubiquitin [cytosol] (Homo sapiens)
UBE2D1/2/3/4 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
Negative regulators of DDX58/IFIH1 signaling (Homo sapiens)
RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS (Homo sapiens)
E2 enzyme (UBE2K, UbcH5a-c) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
RNF125:E2 enzyme (UBE2K, UbcH5a-c):K48-polyubiquitin [cytosol] (Homo sapiens)
E2 enzyme (UBE2K, UbcH5a-c) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Homo sapiens)
UBE2D2,UBE2D1,(CDC34) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1, RIP1-mediated IKK complex recruitment (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
RIP1 ubiqutin ligases [cytosol] (Homo sapiens)
c-IAP1:UBE2D [cytosol] (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
c-IAP2:UBE2D [cytosol] (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
IKK complex recruitment mediated by RIP1 (Homo sapiens)
K63-linked ubiquitination of RIP1 bound to the activated TLR complex (Homo sapiens)
RIP1 ubiqutin ligases [cytosol] (Homo sapiens)
c-IAP1:UBE2D [cytosol] (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
c-IAP2:UBE2D [cytosol] (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
RNF181 polyubiquinates BCL10 (Homo sapiens)
UBE2D1,UBE2D2,UBE2D3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
E2 ubiquitin conjugating enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
UBA6 conjugates ubiquitin to cytosolic E2 enzymes (Homo sapiens)
E2 ubiquitin conjugating enzyme (UBA6 substrate) [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
PELI1 ubiquitinates RIPK3 at K363 (Homo sapiens)
UbcH5a,b,c E2 Conjugating Enzyme:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Protein localization (Homo sapiens)
Peroxisomal protein import (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
PEX2:PEX10:PEX12 monoubiquitinates PEX5S,L at cysteine-11 (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
TNFR1-induced NFkappaB signaling pathway (Homo sapiens)
BIRC(cIAP1/2) ubiquitinates RIPK1 (Homo sapiens)
UBE2D1,2,3:Ubiquitin [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51668 UBE2D1
Gene Names
UBE2D1, SFT, UBC5A, UBCH5, UBCH5A
Chain
chain:1-147
Reference Genes
BioGPS Gene:7321 UBE2D1
COSMIC (genes):UBE2D1 UBE2D1
CTD Gene:7321 UBE2D1
dbSNP Gene:7321 UBE2D1
ENSEMBL:ENSG00000072401 UBE2D1
HGNC:12474 UBE2D1
KEGG Gene (Homo sapiens):7321 UBE2D1
Monarch:7321 UBE2D1
NCBI Gene:7321 UBE2D1
OMIM:602961 UBE2D1
UCSC:P51668 UBE2D1
Reference Transcript
RefSeq:NM_003338.4 UBE2D1
Other Identifiers
0006220592
1164_at
11723042_at
11723043_at
16705064
211764_s_at
214590_s_at
3247758
3247764
3247765
3247766
3247768
3247769
3247771
3247772
3247773
3247774
3247775
37826_at
7321
7927658
A_24_P13032
A_24_P364025
GE79396
GO:0000122
GO:0000151
GO:0000166
GO:0000209
GO:0000278
GO:0002756
GO:0003674
GO:0004842
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006511
GO:0006605
GO:0006625
GO:0006810
GO:0007049
GO:0007165
GO:0008150
GO:0009056
GO:0009058
GO:0015031
GO:0016567
GO:0016579
GO:0016740
GO:0019899
GO:0030509
GO:0031145
GO:0031398
GO:0031625
GO:0032991
GO:0034641
GO:0035666
GO:0043167
GO:0043226
GO:0061630
GO:0061631
GO:0070936
GO:1901990
GO:1902916
HMNXSV003032080
Hs.318435.0.S2_3p_s_at
ILMN_1787988
PH_hs_0007586
TC10000360.hg
g13543662_3p_s_at
Participates
as a member of
E2 ubiquitin conjugating enzyme (UBA1 substrate) [cytosol] (Homo sapiens)
E2 ubiquitin conjugating enzyme (UBA6 substrate) [cytosol] (Homo sapiens)
UBE2D1,2,3 [cytosol] (Homo sapiens)
UBE2D1,UBE2D2,UBE2D3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
UBE2D1/2/3/4 [cytosol] (Homo sapiens)
UBE2D2,UBE2D1,(CDC34) [cytosol] (Homo sapiens)
as a candidate of
E2 enzyme (UBE2K, UbcH5a-c) [cytosol] (Homo sapiens)
E2 Ubiquitin-conjugating enzyme [cytosol] (Homo sapiens)
as a component of
phosphorylated anaphase promoting complex (APC/C) [cytosol] (Homo sapiens)
Other forms of this molecule
Ub-C85-UBE2D1 [cytosol]
UBE2D1 [nucleoplasm]
Inferred To
UBE2D1 [cytosol]
(Bos taurus)
UBE2D1 [cytosol]
(Canis familiaris)
UBE2D1 [cytosol]
(Dictyostelium discoideum)
UBE2D1 [cytosol]
(Gallus gallus)
UBE2D1 [cytosol]
(Plasmodium falciparum)
UBE2D1 [cytosol]
(Sus scrofa)
Homologues of UBE2D1 [cytosol]
(Caenorhabditis elegans)
Homologues of UBE2D1 [cytosol]
(Danio rerio)
Homologues of UBE2D1 [cytosol]
(Dictyostelium discoideum)
Homologues of UBE2D1 [cytosol]
(Drosophila melanogaster)
Homologues of UBE2D1 [cytosol]
(Saccharomyces cerevisiae)
Homologues of UBE2D1 [cytosol]
(Schizosaccharomyces pombe)
uev-3 [cytosol]
(Caenorhabditis elegans)
ubc14 [cytosol]
(Schizosaccharomyces pombe)
ube2d1a [cytosol]
(Danio rerio)
ubc4 [cytosol]
(Schizosaccharomyces pombe)
ubc-22 [cytosol]
(Caenorhabditis elegans)
morgue [cytosol]
(Drosophila melanogaster)
UBC5 [cytosol]
(Saccharomyces cerevisiae)
ube2d1 [cytosol]
(Xenopus tropicalis)
ube2d1b [cytosol]
(Danio rerio)
eff [cytosol]
(Drosophila melanogaster)
Ube2d1 [cytosol]
(Mus musculus)
Ube2d1 [cytosol]
(Rattus norvegicus)
UBC4 [cytosol]
(Saccharomyces cerevisiae)
let-70 [cytosol]
(Caenorhabditis elegans)
ubcB [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_003329.1
OpenTargets
ENSG00000072401
HPA
ENSG00000072401-UBE2D1
GeneCards
P51668
Ensembl
ENST00000373910
,
ENSG00000072401
,
ENSP00000363019
PRO
P51668
PDB
2YHO
,
5FER
,
4AP4
,
4QPL
,
2C4P
,
5TUT
,
6D4P
,
3OJ4
,
3PTF
HMDB Protein
HMDBP00572
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98170 XIAP
3
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
XIAP [cytosol]
(R-HSA-50849)
0.782
6
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.742
5
UniProt:Q9P0P0 RNF181
1
RNF181 [cytoplasm]
(R-HSA-8939317)
0.666
4
UniProt:Q9CZW6
1
Rnf146 [cytosol]
(R-MMU-3640827)
0.558
2
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
UniProt:Q9UHC7 MKRN1
2
p-S109-MKRN1 [cytosol]
(R-HSA-8948758)
MKRN1 [cytosol]
(R-HSA-976042)
0.556
3
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.527
2
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