Reactome | UBE2D1 [nucleoplasm]

UBE2D1 [nucleoplasm]

Stable Identifier

R-HSA-174197

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

UbcH5/Ubc4

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        UBE2D1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51668 UBE2D1

Gene Names

UBE2D1, SFT, UBC5A, UBCH5, UBCH5A

Chain

chain:1-147

Reference Genes

BioGPS Gene:7321 UBE2D1

COSMIC (genes):UBE2D1 UBE2D1

CTD Gene:7321 UBE2D1

dbSNP Gene:7321 UBE2D1

ENSEMBL:ENSG00000072401 UBE2D1

HGNC:12474 UBE2D1

KEGG:hsa:7321 UBE2D1

Monarch:7321 UBE2D1

NCBI Gene:7321 UBE2D1

OMIM:602961 UBE2D1

UCSC:P51668 UBE2D1

Reference Transcript

RefSeq:NM_003338.4 UBE2D1

Other Identifiers

1164_at

11723042_at

11723043_at

16705064

211764_PM_s_at

211764_s_at

214590_PM_s_at

214590_s_at

3247758

3247764

3247765

3247766

3247767

3247768

3247769

3247771

3247772

3247773

3247774

3247775

37826_at

7321

7927658

A_24_P13032

A_24_P364025

GE79396

GO:0000122

GO:0000151

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006511

GO:0016567

GO:0016740

GO:0019787

GO:0030163

GO:0030514

GO:0031398

GO:0031625

GO:0032991

GO:0043161

GO:0043226

GO:0061630

GO:0061631

GO:0070936

GO:0140096

GO:1902916

GO:1904262

HMNXSV003032080

Hs.318435.0.S2_3p_s_at

ILMN_1787988

PH_hs_0007586

TC10000360.hg

g13543662_3p_s_at

Participates

as a member of

as a component of

Other forms of this molecule

UBE2D1 [cytosol]

Ub-C85-UBE2D1 [cytosol]

Inferred To

ube2d1b [nucleoplasm] (Danio rerio)

Homologues of UBE2D1 [nucleoplasm] (Dictyostelium discoideum)

UBE2D1 [nucleoplasm] (Bos taurus)

UBE2D1 [nucleoplasm] (Canis familiaris)

UBE2D1 [nucleoplasm] (Dictyostelium discoideum)

UBE2D1 [nucleoplasm] (Gallus gallus)

UBE2D1 [nucleoplasm] (Sus scrofa)

Ghost homologue of UBE2D1 [nucleoplasm] (Xenopus tropicalis)

Ube2d1 [nucleoplasm] (Mus musculus)

Ube2d1 [nucleoplasm] (Rattus norvegicus)

let-70 [nucleoplasm] (Caenorhabditis elegans)

ubcB [nucleoplasm] (Dictyostelium discoideum)

eff [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_003329.1

Guide to Pharmacology - Targets

3228

OpenTargets

ENSG00000072401

ENSEMBL

ENSP00000363019, ENST00000373910

HPA

ENSG00000072401-UBE2D1

PRO

P51668

Pharos - Targets

P51668

HMDB Protein

HMDBP00572

PDB

2C4P, 5TUT, 2YHO, 5FER, 3PTF, 7ZJ3, 3OJ4, 4QPL, 4AP4, 6D4P

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.851	15
UniProt:Q9Y4L5 RNF115	1	RNF115 [cytosol] (R-HSA-8850904)	0.83	12
UniProt:Q9BV68 RNF126	1	RNF126 [cytosol] (R-HSA-8851642)	0.817	7
UniProt:Q96BH1 RNF25	1	RNF25 [cytosol] (R-HSA-975976)	0.801	6
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.8	6
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.795	10
UniProt:Q8ND25 ZNRF1	1	ZNRF1 [cytosol] (R-HSA-8850903)	0.788	9
UniProt:Q9Y3C5 RNF11			0.788	9
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.782	6
UniProt:Q86UW9 DTX2	1	DTX2 [cytosol] (R-HSA-1604436)	0.781	7
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.781	7
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.742	5
UniProt:Q9H000 MKRN2			0.718	6
UniProt:Q9UJV3-2 MID2			0.718	6
UniProt:Q9P0P0 RNF181	1	RNF181 [cytoplasm] (R-HSA-8939317)	0.666	4
UniProt:Q9BZR9 TRIM8	1	TRIM8 [cytosol] (R-HSA-5624332)	0.666	4
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.666	6
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.666	4
UniProt:Q8N9I9 DTX3			0.666	6
UniProt:Q9UBS8 RNF14	1	RNF14 [cytosol] (R-HSA-5688974)	0.666	4
UniProt:Q96GF1 RNF185	1	RNF185 [endoplasmic reticulum membrane] (R-HSA-8861819)	0.666	4
UniProt:Q13064 MKRN3			0.666	4
IntAct:EBI-4399559 UBIQ			0.623	3
UniProt:Q9Y508 RNF114	1	RNF114 [cytosol] (R-HSA-8850894)	0.621	3
UniProt:Q8N5U6 RNF10			0.621	3
UniProt:Q9CZW6	1	RNF146 [cytosol] (R-MMU-3640827)	0.558	2
UniProt:P62990 UBIQ			0.558	2
UniProt:Q9HCM9-2 TRIM39			0.556	5
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:Q9BVG3 TRIM62	1	TRIM62 [cytosol] (R-HSA-5624340)	0.556	3
UniProt:Q86XT4 TRIM50	1	TRIM50 [cytosol] (R-HSA-5688976)	0.556	5
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9UHC7 MKRN1	2	p-S109-MKRN1 [cytosol] (R-HSA-8948758) MKRN1 [cytosol] (R-HSA-976042)	0.556	3
UniProt:Q8N6D2 RNF182	1	RNF182 [cytosol] (R-HSA-976010)	0.556	3
UniProt:Q96B67 ARRD3			0.556	5
UniProt:Q9HAC8 UBTD1			0.556	3
IntAct:EBI-22462114 CCSB ORF ID			0.556	3
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.556	3
IntAct:EBI-23192465 CCSB ORF ID			0.556	3
UniProt:Q96EP1-2 CHFR			0.556	3
UniProt:O75382 TRIM3	1	TRIM3 [cytosol] (R-HSA-5624344)	0.556	3
UniProt:Q6PCD5 RFWD3			0.553	2
UniProt:Q9UKV5 AMFR	1	AMFR [endoplasmic reticulum membrane] (R-HSA-975999)	0.553	2
UniProt:Q9NS56 TOPORS	2	monoSUMO1-K560-TOPORS [nucleoplasm] (R-HSA-4551754) TOPORS [nucleoplasm] (R-HSA-2993791)	0.547	2
UniProt:O88846	1	RNF4 [cytosol] (R-RNO-975974)	0.544	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.527	2
UniProt:Q96EP1 CHFR			0.488	2
UniProt:Q9NZS9 BFAR			0.488	2
UniProt:Q86Y13 DZIP3	1	DZIP3 [cytosol] (R-HSA-976002)	0.488	2

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