Reactome | XPO1 [nucleoplasm]

XPO1 [nucleoplasm]

Stable Identifier

R-HSA-165529

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CRM1

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by NPAS4 (Homo sapiens)
      - NPAS4 regulates expression of target genes (Homo sapiens)
        
        NPAS4 translocates to the cytosol (Homo sapiens)
        
        XPO1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14980 XPO1

Gene Names

XPO1, CRM1

Chain

chain:1-1071

Reference Genes

BioGPS Gene:7514 XPO1

COSMIC (genes):XPO1 XPO1

CTD Gene:7514 XPO1

dbSNP Gene:7514 XPO1

ENSEMBL:ENSG00000082898 XPO1

ENSEMBL_homo_sapiens_GENE:ENSG00000082898.19 XPO1

HGNC:12825 XPO1

KEGG Gene (Homo sapiens):7514 XPO1

Monarch:7514 XPO1

NCBI Gene:7514 XPO1

OMIM:602559 XPO1

UCSC:O14980 XPO1

Reference Transcript

Other Identifiers

11716623_a_at

11716624_s_at

11748585_a_at

11748586_x_at

16898110

208775_PM_at

208775_at

2555491

2555492

2555493

2555497

2555498

2555501

2555503

2555505

2555507

2555509

2555510

2555511

2555512

2555513

2555514

2555516

2555518

2555520

2555521

2555522

2555523

2555524

2555525

2555527

2555533

2555539

2555542

2555543

2555544

2555545

2555546

2555547

2555548

2555566

2555567

37729_at

7514

8052526

A_23_P40078

GO:0000054

GO:0000055

GO:0000056

GO:0000776

GO:0003723

GO:0005049

GO:0005515

GO:0005634

GO:0005635

GO:0005642

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0006406

GO:0006611

GO:0006886

GO:0006913

GO:0007010

GO:0010824

GO:0015030

GO:0015031

GO:0016020

GO:0030163

GO:0031267

GO:0031965

GO:0032434

GO:0032991

GO:0034504

GO:0042176

GO:0042254

GO:0043226

GO:0043231

GO:0046825

GO:0051028

GO:0140104

GO:1990904

HMNXSV003041015

ILMN_1725121

PH_hs_0022722

TC02001893.hg

Y08614_at

g2626839_3p_at

Participates

as a component of

as an input of

This entity regulates

Positively

Other forms of this molecule

XPO1 [cytosol]

Inferred To

Ghost homologue of XPO1 [nucleoplasm] (Danio rerio)

Ghost homologue of XPO1 [nucleoplasm] (Xenopus tropicalis)

Xpo1 [nucleoplasm] (Mus musculus)

Xpo1 [nucleoplasm] (Rattus norvegicus)

emb [nucleoplasm] (Drosophila melanogaster)

CRM1 [nucleoplasm] (Saccharomyces cerevisiae)

xpo1 [nucleoplasm] (Dictyostelium discoideum)

xpo1 [nucleoplasm] (Schizosaccharomyces pombe)

XPO1 [nucleoplasm] (Bos taurus)

XPO1 [nucleoplasm] (Canis familiaris)

XPO1 [nucleoplasm] (Gallus gallus)

XPO1 [nucleoplasm] (Plasmodium falciparum)

XPO1 [nucleoplasm] (Sus scrofa)

xpo-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003391.1, XP_006712157.1, XP_011531399.1

Guide to Pharmacology - Targets

3014

OpenTargets

ENSG00000082898

ZINC - Substances

XPO1_HUMAN

ZINC - Biogenic

XPO1_HUMAN

ZINC target

O14980

PRO

O14980

PDB

3GB8, 7B51, 5DIS, 1W9C, 4BSN, 2L1L, 6TVO, 4BSM

HPA

ENSG00000082898-XPO1

GeneCards

O14980

Ensembl

ENSP00000503572, ENSP00000504087, ENST00000404992, ENSP00000503809, ENSP00000504247, ENSP00000504543, ENST00000677928, ENST00000406957, ENST00000401558, ENST00000677239, ENST00000678182, ENST00000677814, ENST00000677933, ENST00000677417, ENST00000677813, ENST00000676667, ENSP00000503419, ENSP00000504848, ENST00000677150, ENSP00000385942, ENSP00000385559, ENSP00000384863, ENSP00000504594, ENSP00000503482, ENSG00000082898, ENST00000678790, ENST00000676553, ENSP00000503167, ENSP00000504198

Pharos - Targets

O14980

ZINC - Predictions - Purchasable

XPO1_HUMAN

Orphanet

25041

HMDB Protein

HMDBP08617

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95149 SNUPN	1	SNUPN [cytosol] (R-HSA-191857)	0.817	8
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	24
UniProt:P04618 rev	3	REV (P04618) protein [extracellular region] (R-HIV-174998) REV (P04618) protein [nucleoplasm] (R-HIV-175380) REV (P04618) protein [cytosol] (R-HIV-173267)	0.609	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.589	3
15-deoxy-Delta(12,14)-prostaglandin J2 [ChEBI:34159]	2	15d-PGJ2 [endoplasmic reticulum lumen] (R-ALL-2142702) 15d-PGJ2 [nucleoplasm] (R-ALL-9855639)	0.576	4
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:P18754 RCC1	2	RCC1 [nucleoplasm] (R-HSA-180690) RCC1 [chromosome] (R-HSA-9668547)	0.564	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.564	3
UniProt:Q99567 NUP88	1	NUP88 [cytosol] (R-HSA-157753)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:P0DTD8 NS7B			0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.524	2
UniProt:Q9WMX2 POLG			0.499	3
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.499	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.462	2

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