Reactome | DDX58 [cytosol]

DDX58 [cytosol]

Stable Identifier

R-HSA-168917

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RIG-I

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Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
15208624	The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses Taira, K, Shinobu, N, Yoneyama, M, Fujita, T, Miyagishi, M, Kikuchi, M, Imaizumi, T, Natsukawa, T	Nat Immunol	2004

External Reference Information

External Reference

UniProt:O95786 RIGI

Gene Names

RIGI, DDX58

Chain

chain:1-925

Reference Genes

BioGPS Gene:23586 RIGI

CTD Gene:23586 RIGI

dbSNP Gene:23586 RIGI

ENSEMBL:ENSG00000107201 DDX58

ENSEMBL_homo_sapiens_GENE:ENSG00000107201.11 RIGI

HGNC:19102 RIGI

KEGG Gene (Homo sapiens):23586 RIGI

Monarch:23586 RIGI

NCBI Gene:23586 RIGI

OMIM:609631 RIGI

UCSC:O95786 RIGI

Reference Transcript

RefSeq:NM_014314.3 RIGI

Other Identifiers

11733149_a_at

11755819_a_at

11756330_a_at

17093090

218943_PM_s_at

218943_s_at

222793_PM_at

222793_at

23586

242961_3p_x_at

242961_PM_x_at

242961_x_at

3203087

3203088

3203089

3203090

3203091

3203092

3203093

3203095

3203096

3203097

3203098

3203101

3203103

3203104

3203105

3203106

3203107

3203108

3203109

3203110

3203111

3203113

3203115

3203121

59215_at

76098_r_at

77749_at

8160559

A_23_P20814

A_33_P3372910

A_33_P3418170

GE54334

GO:0000166

GO:0002230

GO:0002376

GO:0002735

GO:0002753

GO:0003676

GO:0003677

GO:0003690

GO:0003723

GO:0003724

GO:0003725

GO:0003727

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005525

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005923

GO:0006351

GO:0006355

GO:0008270

GO:0009597

GO:0009615

GO:0010467

GO:0010628

GO:0015629

GO:0016020

GO:0016787

GO:0016887

GO:0023052

GO:0030334

GO:0031625

GO:0032587

GO:0032725

GO:0032727

GO:0032728

GO:0032755

GO:0032757

GO:0032760

GO:0034344

GO:0038187

GO:0039529

GO:0042802

GO:0042995

GO:0043226

GO:0043330

GO:0045087

GO:0045944

GO:0046872

GO:0048870

GO:0050896

GO:0051091

GO:0051607

GO:0060089

GO:0060760

GO:0070161

GO:0071360

GO:0098542

GO:0140098

GO:0140374

GO:0140657

GO:1990904

HMNXSV003031097

Hs.145612.0.S2_3p_at

Hs.263536.0.A1_3p_at

Hs.263536.0.A1_3p_x_at

ILMN_1797001

PH_hs_0005775

PH_hs_0025667

TC09000999.hg

g7657515_3p_a_at

Participates

as a member of

as a component of

as an input of

as a candidate of

ISG15 targets [cytosol] (Homo sapiens)

as an output of

CYLD mediated deubiquitination of DDX58 (RIG-I) (Homo sapiens)

Other forms of this molecule

PolyUb-DDX58 [cytosol]

K48polyUb-DDX58 [cytosol]

K63polyUb-DDX58 [cytosol]

Inferred To

DDX58 [cytosol] (Bos taurus)

DDX58 [cytosol] (Caenorhabditis elegans)

DDX58 [cytosol] (Mus musculus)

DDX58 [cytosol] (Plasmodium falciparum)

DDX58 [cytosol] (Rattus norvegicus)

DDX58 [cytosol] (Saccharomyces cerevisiae)

DDX58 [cytosol] (Sus scrofa)

helF [cytosol] (Dictyostelium discoideum)

rigi [cytosol] (Xenopus tropicalis)

Homologues of DDX58 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_055129.2

Guide to Pharmacology - Targets

2920

GeneCards

O95786

HPA

ENSG00000107201-RIGI

Ensembl

ENST00000379868, ENSP00000369213, ENST00000379883, ENSG00000107201, ENSP00000369197

PRO

O95786

Pharos - Targets

O95786

Orphanet

23141

HMDB Protein

HMDBP11688

PDB

7TNX, 8G7T, 3LRN, 7JL3, 6KYV, 4ON9, 3NCU, 2YKG, 8DVU, 3LRR, 8DVS, 4P4H, 7MK1, 7BAI, 5F9F, 5E3H, 5F9H, 4AY2, 4BPB, 7JL1, 8DVR, 2RMJ, 3OG8, 5F98, 7TO2, 3ZD7, 4NQK, 7BAH, 2LWD, 2QFB, 7TO0, 7TNY, 2QFD, 6GPG, 8G7U, 2LWE, 7TO1, 7TNZ, 3ZD6, 8G7V

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.956	19
UniProt:Q14258 TRIM25	2	TRIM25 [nucleoplasm] (R-HSA-5653667) TRIM25 [cytosol] (R-HSA-918186)	0.845	9
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.786	15
UniProt:P0DTD1-PRO_0000449623 REP			0.72	6
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.688	5
ChEBI:84491 POLY(I			0.656	3
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.656	3
IntAct:EBI-26608251 NC			0.65	9
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.619	6
UniProt:Q96EQ8 RNF125	2	RNF125 [cytosol] (R-HSA-918184) K48polyUb-RNF125 [cytosol] (R-HSA-3080560)	0.591	4
UniProt:A0A0B5AC19 NSS			0.59	5
UniProt:Q7Z2W4-2 ZC3HAV1			0.589	4
UniProt:P59596 M	10	M [plasma membrane] (R-COV-9731038) M [Golgi membrane] (R-COV-9683651) N-glycan M [endoplasmic reticulum membrane] (R-COV-9683588) nascent M [endoplasmic reticulum lumen] (R-COV-9683586) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684206) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9684213) M [endocytic vesicle membrane] (R-COV-9686687) N-glycan M [endocytic vesicle membrane] (R-COV-9686698) M [virion membrane] (R-COV-9678151) N-glycan M [virion membrane] (R-COV-9685474)	0.589	4
IntAct:EBI-26977473 3PRNA			0.558	2
UniProt:Q920D5 CASPC			0.557	4
UniProt:Q6IUF9 Z			0.544	3
UniProt:Q6IVU5 Z			0.544	3
IntAct:EBI-26977583 3’UTR-SENSE			0.544	4
UniProt:Q6UY71 Z			0.544	3
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.524	3
UniProt:P04487 RNB			0.524	4
UniProt:Q9NQC7 CYLD	3	K48polyUb-K338, K530-CYLD [cytosol] (R-HSA-9818664) p-S418-CYLD [cytosol] (R-HSA-5212667) CYLD [cytosol] (R-HSA-741420)	0.524	2
UniProt:Q96S55 WRIP1			0.499	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.463	3
UniProt:P0DTD2 9b	3	p-S53-9b [cytosol] (R-COV-9758478) 9b [cytosol] (R-COV-9694649) 9b [mitochondrial outer membrane] (R-COV-9709803)	0.463	2

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