Reactome | p-T222,T225-GORASP2 [Golgi membrane]

p-T222,T225-GORASP2 [Golgi membrane]

Stable Identifier

R-HSA-2422965

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H8Y8 GORASP2

Gene Names

GORASP2, GOLPH6

Chain

initiator methionine:1, chain:2-452

Reference Genes

BioGPS Gene:26003 GORASP2

COSMIC (genes):GORASP2 GORASP2

CTD Gene:26003 GORASP2

dbSNP Gene:26003 GORASP2

ENSEMBL:ENSG00000115806 GORASP2

ENSEMBL:ENSG00000115806.13 GORASP2

HGNC:17500 GORASP2

KEGG Gene (Homo sapiens):26003 GORASP2

Monarch:26003 GORASP2

NCBI Gene:26003 GORASP2

OMIM:608693 GORASP2

UCSC:Q9H8Y8 GORASP2

Reference Transcript

Other Identifiers

11742760_a_at

11742761_x_at

11747151_a_at

11751303_s_at

16887531

207812_PM_s_at

207812_s_at

208842_PM_s_at

208842_s_at

208843_PM_s_at

208843_s_at

2515060

2515061

2515062

2515069

2515070

2515072

2515073

2515074

2515075

2515077

2515080

2515081

2515085

2515087

2515094

2515095

2515096

2515097

26003

35805_at

8046306

A_14_P106528

A_23_P165494

A_24_P328320

GE56466

GO:0000139

GO:0005515

GO:0005783

GO:0005789

GO:0005794

GO:0005801

GO:0006996

GO:0007030

GO:0007283

GO:0016020

GO:0022414

GO:0030154

GO:0034976

GO:0043226

GO:0061951

GO:0070925

GO:0072659

HMNXSV003057684

Hs.6880.1.S1_3p_a_at

ILMN_1748018

PH_hs_0000700

g7661569_3p_a_at

Participates

as a component of

p-T222,225-GORASP2:BLZF1:RAB2A:GTP [Golgi membrane] (Homo sapiens)

Other forms of this molecule

GORASP2 [Golgi membrane]

Inferred To

Ghost homologue of p-T222,T225-GORASP2 [Golgi membrane] (Rattus norvegicus)

phospho-GORASP2 [Golgi membrane] (Bos taurus)

phospho-GORASP2 [Golgi membrane] (Sus scrofa)

phospho-Gorasp2 [Golgi membrane] (Mus musculus)

phospho-gorasp2 [Golgi membrane] (Xenopus tropicalis)

phospho-Grasp65 [Golgi membrane] (Drosophila melanogaster)

phospho-p-T222,T225-GORASP2 [Golgi membrane] (Caenorhabditis elegans)

phospho-p-T222,T225-GORASP2 [Golgi membrane] (Canis familiaris)

phospho-p-T222,T225-GORASP2 [Golgi membrane] (Danio rerio)

phospho-p-T222,T225-GORASP2 [Golgi membrane] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 225

Coordinate

225

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 222

Coordinate

222

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001188357.1, XP_006712471.1, NP_056345.3

OpenTargets

ENSG00000115806

GeneCards

Q9H8Y8

HPA

ENSG00000115806-GORASP2

Ensembl

ENST00000234160, ENSP00000234160, ENSG00000115806

PRO

Q9H8Y8

Pharos - Targets

Q9H8Y8

PDB

3RLE, 4EDJ

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49247 RPIA	2	RPIA [cytosol] (R-HSA-71304) RPIA A61V [cytosol] (R-HSA-5660009)	0.83	8
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.83	8
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.799	7
UniProt:P11926 ODC1	1	PXLP-K69-ODC1 [cytosol] (R-HSA-70689)	0.781	11
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.781	7
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.781	7
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.781	8
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.718	6
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.666	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.646	6
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:Q9Y547 IFT25	2	HSPB11 [ciliary tip] (R-HSA-5625342) HSPB11 [cilium] (R-HSA-5617628)	0.556	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:P63211 GNGT1	3	S-farn-GNGT1 [photoreceptor disc membrane] (R-HSA-2530520) GNGT1 [photoreceptor disc membrane] (R-HSA-55393) GNGT1 [plasma membrane] (R-HSA-167428)	0.556	5
UniProt:P17752 TPH1	1	TPH1 [cytosol] (R-HSA-976250)	0.556	5
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.556	3
UniProt:Q96S44 TP53RK	1	TP53RK [nucleoplasm] (R-HSA-6784489)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:P50281 MMP14	3	MMP14 [plasma membrane] (R-HSA-1442472) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724)	0.463	2

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