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2xAcK-SMC3 [cytosol]
Stable Identifier
R-HSA-2484792
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ac-SMC3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
Deacetylation of cleaved cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:WAPAL [cytosol] (Homo sapiens)
Cleaved Cohesin [cytosol] (Homo sapiens)
2xAcK-SMC3 [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:WAPAL [cytosol] (Homo sapiens)
Cleaved Cohesin [cytosol] (Homo sapiens)
2xAcK-SMC3 [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
Deacetylation of cohesin (Homo sapiens)
p-Ac-Cohesin:PDS5:WAPAL [cytosol] (Homo sapiens)
p-Ac-Cohesin [cytosol] (Homo sapiens)
2xAcK-SMC3 [cytosol] (Homo sapiens)
Resolution of sister chromatids (Homo sapiens)
p-Ac-Cohesin:PDS5:WAPAL [cytosol] (Homo sapiens)
p-Ac-Cohesin [cytosol] (Homo sapiens)
2xAcK-SMC3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQE7 SMC3
Gene Names
SMC3, BAM, BMH, CSPG6, SMC3L1
Chain
chain:1-1217
Reference Genes
BioGPS Gene:9126 SMC3
COSMIC (genes):SMC3 SMC3
CTD Gene:9126 SMC3
dbSNP Gene:9126 SMC3
ENSEMBL:ENSG00000108055 SMC3
HGNC:2468 SMC3
KEGG:hsa:9126 SMC3
Monarch:9126 SMC3
NCBI Gene:9126 SMC3
OMIM:606062 SMC3
UCSC:Q9UQE7 SMC3
Reference Transcript
RefSeq:NM_005445.3 SMC3
Other Identifiers
11725679_at
11725680_at
11758700_s_at
1556925_PM_at
1556925_at
16709140
209257_PM_s_at
209257_s_at
209258_PM_s_at
209258_s_at
209259_PM_s_at
209259_s_at
2495747
2495749
2495751
2495753
3263792
3263793
3263794
3263795
3263796
3263797
3263799
3263800
3263801
3263802
3263803
3263804
3263805
3263806
3263807
3263809
3263810
3263811
3263813
3263814
3263815
3263816
3263817
3263818
3263819
3263820
3263822
3263823
3263824
3263825
3263827
3263828
3263830
3263832
3263833
3263834
3263835
3263836
3263837
34763_at
57506_at
7930422
9126
A_14_P107296
A_23_P138631
A_32_P15364
GE54158
GO:0000278
GO:0000775
GO:0000785
GO:0000800
GO:0003677
GO:0003682
GO:0003690
GO:0003774
GO:0003777
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006275
GO:0006281
GO:0007010
GO:0007062
GO:0007064
GO:0008092
GO:0008278
GO:0016363
GO:0016787
GO:0016887
GO:0019827
GO:0022414
GO:0030892
GO:0030893
GO:0034087
GO:0034089
GO:0036033
GO:0043226
GO:0046982
GO:0048487
GO:0051276
GO:0051301
GO:0051321
GO:0070840
GO:0090307
GO:0097431
GO:0140657
HMNXSV003015259
Hs.24485.0.A1_3p_a_at
Hs.24485.0.A2_3p_a_at
Hs2.397934.1.S1_3p_at
ILMN_1718807
ILMN_1869354
ILMN_2182348
PH_hs_0006787
PH_hs_0027602
TC10000802.hg
g3089367_3p_a_at
Participates
as a component of
Cleaved Cohesin [cytosol] (Homo sapiens)
p-Ac-Cohesin [cytosol] (Homo sapiens)
Other forms of this molecule
SMC3 [cytosol]
2xAcK-SMC3 [chromosome]
2xAcK-SMC3 [chromosome, centromeric region]
2xAcK-SMC3 [nucleoplasm]
SMC3 [nucleoplasm]
Inferred To
2xAcK-SMC3 [cytosol]
(Dictyostelium discoideum)
2xAcK-SMC3 [cytosol]
(Mus musculus)
2xAcK-SMC3 [cytosol]
(Rattus norvegicus)
2xAcK-SMC3 [cytosol]
(Saccharomyces cerevisiae)
2xAcK-SMC3 [cytosol]
(Schizosaccharomyces pombe)
SMC3 [cytosol]
(Bos taurus)
SMC3 [cytosol]
(Canis familiaris)
SMC3 [cytosol]
(Drosophila melanogaster)
SMC3 [cytosol]
(Gallus gallus)
SMC3 [cytosol]
(Sus scrofa)
smc-3 [cytosol]
(Caenorhabditis elegans)
smc3 [cytosol]
(Danio rerio)
Modified Residues
Name
N6-acetyl-L-lysine at 105
Coordinate
105
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Name
N6-acetyl-L-lysine at 106
Coordinate
106
PsiMod Name
N6-acetyl-L-lysine [MOD:00064]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-acetyl-L-lysine.
Cross References
RefSeq
NP_005436.1
ENSEMBL
ENSP00000354720
,
ENST00000361804
OpenTargets
ENSG00000108055
HPA
ENSG00000108055-SMC3
PRO
Q9UQE7
Pharos - Targets
Q9UQE7
GlyGen
Q9UQE7
Orphanet
SMC3
PDB
6WG3
,
7W1M
,
6WG6
,
6WGE
,
6WG4
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60216 RAD21
14
RAD21 [nucleoplasm]
(R-HSA-163042)
RAD21 [chromosome, centromeric region]
(R-HSA-2466012)
RAD21 [chromosome]
(R-HSA-1638775)
p-S454-RAD21 [chromosome, centromeric region]
(R-HSA-2485163)
p-S454-RAD21 [cytosol]
(R-HSA-2500310)
p-S454-RAD21 [chromosome]
(R-HSA-2485164)
RAD21(1-172) [chromosome, centromeric region]
(R-HSA-2467793)
p-S454-RAD21(451-631) [chromosome, centromeric region]
(R-HSA-2467790)
RAD21(173-450) [chromosome, centromeric region]
(R-HSA-2500296)
RAD21(1-172) [cytosol]
(R-HSA-2484901)
RAD21(173-450) [cytosol]
(R-HSA-2500308)
p-S454-RAD21(451-631) [cytosol]
(R-HSA-2500309)
RAD21 [cytosol]
(R-HSA-2484795)
monoSUMO1-K-RAD21 [nucleoplasm]
(R-HSA-3108183)
0.956
18
UniProt:Q7Z5K2 WAPL
4
WAPAL [cytosol]
(R-HSA-2484802)
WAPAL [chromosome]
(R-HSA-2577090)
WAPAL [chromosome, centromeric region]
(R-HSA-2577088)
WAPAL [nucleoplasm]
(R-HSA-2466355)
0.822
13
UniProt:Q96FF9 CDCA5
6
p-S21,S75,T159-CDCA5 [cytosol]
(R-HSA-2484804)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region]
(R-HSA-2468269)
p-S21,S75,T159-CDCA5 [chromosome]
(R-HSA-2468266)
CDCA5 [chromosome]
(R-HSA-2468149)
CDCA5 [chromosome, centromeric region]
(R-HSA-2468260)
CDCA5 [nucleoplasm]
(R-HSA-2466357)
0.744
6
UniProt:Q9CPY3
6
phospho-Cdca5 [cytosol]
(R-MMU-2484804)
phospho-Cdca5 [chromosome, centromeric region]
(R-MMU-2468269)
phospho-Cdca5 [chromosome]
(R-MMU-2468266)
Cdca5 [chromosome]
(R-MMU-2468149)
Cdca5 [chromosome, centromeric region]
(R-MMU-2468260)
Cdca5 [nucleoplasm]
(R-MMU-2466357)
0.669
3
UniProt:Q61550 Rad21
15
Rad21 [nucleoplasm]
(R-MMU-3108183)
Double-strand-break repair protein rad21 homolog [nucleoplasm]
(R-MMU-912350)
Rad21 [cytosol]
(R-MMU-2484795)
phospho-Rad21 [cytosol]
(R-MMU-2500309)
Rad21 [cytosol]
(R-MMU-2500308)
Rad21 [cytosol]
(R-MMU-2484901)
Rad21 [chromosome, centromeric region]
(R-MMU-2500296)
phospho-Rad21 [chromosome, centromeric region]
(R-MMU-2467790)
Rad21 [chromosome, centromeric region]
(R-MMU-2467793)
phospho-Rad21 [chromosome]
(R-MMU-2485164)
phospho-Rad21 [cytosol]
(R-MMU-2500310)
phospho-Rad21 [chromosome, centromeric region]
(R-MMU-2485163)
Rad21 [chromosome]
(R-MMU-1638775)
Rad21 [chromosome, centromeric region]
(R-MMU-2466012)
Rad21 [nucleoplasm]
(R-MMU-163042)
0.564
2
UniProt:P35998 PSMC2
5
PSMC2 [cytosol]
(R-HSA-68771)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
0.527
2
UniProt:Q92995 USP13
2
USP13 [nucleoplasm]
(R-HSA-6781924)
USP13 [cytosol]
(R-HSA-6781893)
0.527
2
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.483
2
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