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monoSUMO1-K-RAD21 [nucleoplasm]
Stable Identifier
R-HSA-3108183
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUMO1 N-glycyl-lys RAD21
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1 (Homo sapiens)
SUMOylated Cohesin [nucleoplasm] (Homo sapiens)
monoSUMO1-K-RAD21 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60216 RAD21
Gene Names
RAD21, HR21, KIAA0078, NXP1, SCC1
Chain
chain:1-631, chain:280-631
Reference Genes
BioGPS Gene:5885 RAD21
COSMIC (genes):RAD21 RAD21
CTD Gene:5885 RAD21
dbSNP Gene:5885 RAD21
ENSEMBL:ENSG00000164754 RAD21
ENSEMBL_homo_sapiens_GENE:ENSG00000164754.16 RAD21
HGNC:9811 RAD21
KEGG Gene (Homo sapiens):5885 RAD21
Monarch:5885 RAD21
NCBI Gene:5885 RAD21
OMIM:606462 RAD21
UCSC:O60216 RAD21
Reference Transcript
RefSeq:NM_006265.2 RAD21
Other Identifiers
11716436_s_at
11716437_a_at
11716438_at
11754303_s_at
17080408
200607_PM_s_at
200607_s_at
200608_PM_s_at
200608_s_at
3149849
3149850
3149852
3149855
3149857
3149858
3149861
3149862
3149863
3149864
3149865
3149866
3149869
3149871
3149873
3149880
3149881
3149882
3149883
38114_at
3984533
3984537
5885
8152477
D38551_at
GE57195
GO:0000228
GO:0000278
GO:0000775
GO:0000785
GO:0000794
GO:0000922
GO:0001666
GO:0003677
GO:0003682
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006915
GO:0006974
GO:0007049
GO:0007059
GO:0007062
GO:0007131
GO:0008278
GO:0010628
GO:0010629
GO:0010972
GO:0012501
GO:0016020
GO:0016043
GO:0016363
GO:0022414
GO:0030496
GO:0030892
GO:0030893
GO:0032691
GO:0032720
GO:0032733
GO:0034087
GO:0034089
GO:0034351
GO:0043226
GO:0043524
GO:0045841
GO:0045876
GO:0051301
GO:0071168
GO:0106222
GO:0140013
GO:0140014
GO:0140297
GO:0140588
GO:1990414
HMNXSV003020959
HMNXSV003027934
Hs.81848.0.S1_3p_a_at
PH_hs_0004675
TC08001546.hg
g5453993_3p_a_at
Participates
as a component of
SUMOylated Cohesin [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S454-RAD21 [cytosol]
p-S454-RAD21 [chromosome]
RAD21 [cytosol]
p-S454-RAD21(451-631) [cytosol]
RAD21(173-450) [cytosol]
RAD21(1-172) [cytosol]
RAD21(173-450) [chromosome, centromeric region]
p-S454-RAD21(451-631) [chromosome, centromeric region]
RAD21(1-172) [chromosome, centromeric region]
p-S454-RAD21 [chromosome, centromeric region]
RAD21 [chromosome]
RAD21 [nucleoplasm]
RAD21 [chromosome, centromeric region]
Inferred To
Rad21 [nucleoplasm]
(Mus musculus)
Rad21 [nucleoplasm]
(Rattus norvegicus)
rec8 [nucleoplasm]
(Schizosaccharomyces pombe)
RAD21 [nucleoplasm]
(Bos taurus)
RAD21 [nucleoplasm]
(Gallus gallus)
RAD21 [nucleoplasm]
(Sus scrofa)
Homologues of monoSUMO1-K-RAD21 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of monoSUMO1-K-RAD21 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of monoSUMO1-K-RAD21 [nucleoplasm]
(Schizosaccharomyces pombe)
rad21b [nucleoplasm]
(Danio rerio)
coh-1 [nucleoplasm]
(Caenorhabditis elegans)
rad21 [nucleoplasm]
(Schizosaccharomyces pombe)
scc-1 [nucleoplasm]
(Caenorhabditis elegans)
monoSUMO1-K-RAD21 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of monoSUMO1-K-RAD21 [nucleoplasm]
(Xenopus tropicalis)
rec-8 [nucleoplasm]
(Caenorhabditis elegans)
MCD1 [nucleoplasm]
(Saccharomyces cerevisiae)
REC8 [nucleoplasm]
(Saccharomyces cerevisiae)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at unknown position
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_006256.1
OpenTargets
ENSG00000164754
GeneCards
O60216
HPA
ENSG00000164754-RAD21
Ensembl
ENSG00000164754
,
ENST00000522699
,
ENSP00000509687
,
ENST00000687358
,
ENST00000520992
,
ENST00000297338
,
ENSP00000430524
,
ENST00000517749
,
ENST00000519837
,
ENSP00000430273
,
ENSP00000297338
,
ENSP00000429342
,
ENSP00000428158
,
ENST00000517485
,
ENSP00000427923
PRO
O60216
Pharos - Targets
O60216
Orphanet
21189
PDB
6WG3
,
4PK7
,
4PJU
,
7W1M
,
6WGE
,
4PJW
,
7ZJS
,
6QNX
,
6RRK
,
6RRC
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N3U4 STAG2
8
monoSUMO1-K-STAG2 [nucleoplasm]
(R-HSA-3108187)
p-STAG2 [chromosome, centromeric region]
(R-HSA-2466013)
p-STAG2 [cytosol]
(R-HSA-2484806)
p-STAG2 [chromosome]
(R-HSA-1638793)
STAG2 [cytosol]
(R-HSA-2484897)
STAG2 [chromosome]
(R-HSA-1638777)
STAG2 [chromosome, centromeric region]
(R-HSA-2466018)
STAG2 [nucleoplasm]
(R-HSA-163046)
0.966
22
UniProt:Q9UQE7 SMC3
6
SMC3 [cytosol]
(R-HSA-2545223)
2xAcK-SMC3 [cytosol]
(R-HSA-2484792)
2xAcK-SMC3 [chromosome]
(R-HSA-2468146)
2xAcK-SMC3 [chromosome, centromeric region]
(R-HSA-2468148)
2xAcK-SMC3 [nucleoplasm]
(R-HSA-2468050)
SMC3 [nucleoplasm]
(R-HSA-163009)
0.956
18
UniProt:Q14683 SMC1A
4
SMC1A [cytosol]
(R-HSA-2484798)
SMC1A [chromosome]
(R-HSA-1638774)
SMC1A [chromosome, centromeric region]
(R-HSA-2466015)
SMC1A [nucleoplasm]
(R-HSA-64561)
0.926
18
UniProt:Q8WVM7 STAG1
4
STAG1 [cytosol]
(R-HSA-2484793)
STAG1 [chromosome]
(R-HSA-1638773)
STAG1 [nucleoplasm]
(R-HSA-163016)
STAG1 [chromosome, centromeric region]
(R-HSA-2466017)
0.918
12
UniProt:Q7Z5K2 WAPL
4
WAPAL [cytosol]
(R-HSA-2484802)
WAPAL [chromosome]
(R-HSA-2577090)
WAPAL [chromosome, centromeric region]
(R-HSA-2577088)
WAPAL [nucleoplasm]
(R-HSA-2466355)
0.905
18
UniProt:Q29RF7 PDS5A
4
PDS5A [cytosol]
(R-HSA-2484799)
PDS5A [chromosome]
(R-HSA-2466360)
PDS5A [chromosome, centromeric region]
(R-HSA-2468259)
PDS5A [nucleoplasm]
(R-HSA-2468043)
0.857
6
UniProt:Q9NTI5 PDS5B
4
PDS5B [cytosol]
(R-HSA-2484800)
PDS5B [chromosome]
(R-HSA-2466361)
PDS5B [chromosome, centromeric region]
(R-HSA-2468263)
PDS5B [nucleoplasm]
(R-HSA-2468051)
0.813
5
UniProt:Q5FBB7 SGO1
1
SGOL1 [cytosol]
(R-HSA-376227)
0.737
6
UniProt:Q9NP77 SSU72
1
SSU72 [nucleoplasm]
(R-HSA-6814915)
0.674
9
UniProt:Q9CPY3
6
phospho-Cdca5 [chromosome]
(R-MMU-2468266)
phospho-Cdca5 [cytosol]
(R-MMU-2484804)
phospho-Cdca5 [chromosome, centromeric region]
(R-MMU-2468269)
Cdca5 [chromosome]
(R-MMU-2468149)
Cdca5 [chromosome, centromeric region]
(R-MMU-2468260)
Cdca5 [nucleoplasm]
(R-MMU-2466357)
0.669
3
UniProt:Q13643 FHL3
0.666
4
UniProt:Q96FF9 CDCA5
6
p-S21,S75,T159-CDCA5 [chromosome]
(R-HSA-2468266)
p-S21,S75,T159-CDCA5 [cytosol]
(R-HSA-2484804)
p-S21,S75,T159-CDCA5 [chromosome, centromeric region]
(R-HSA-2468269)
CDCA5 [chromosome]
(R-HSA-2468149)
CDCA5 [chromosome, centromeric region]
(R-HSA-2468260)
CDCA5 [nucleoplasm]
(R-HSA-2466357)
0.643
4
UniProt:Q9CW03 Smc3
6
SMC3 [cytosol]
(R-MMU-2545223)
2xAcK-SMC3 [cytosol]
(R-MMU-2484792)
2xAcK-SMC3 [chromosome]
(R-MMU-2468146)
2xAcK-SMC3 [chromosome, centromeric region]
(R-MMU-2468148)
2xAcK-SMC3 [nucleoplasm]
(R-MMU-2468050)
Structural maintenance of chromosomes protein 3 [nucleoplasm]
(R-MMU-912387)
0.597
5
UniProt:Q8NFQ8 TOIP2
0.527
2
UniProt:A9IYQ1 A9IYQ1
0.527
2
UniProt:Q9HCH3 CPNE5
0.527
2
UniProt:Q92995 USP13
2
USP13 [nucleoplasm]
(R-HSA-6781924)
USP13 [cytosol]
(R-HSA-6781893)
0.527
2
UniProt:P13497 BMP1
1
BMP1 [extracellular region]
(R-HSA-2002393)
0.527
2
UniProt:Q9NTI5-2 PDS5B
0.527
2
UniProt:Q8N3U4-2 STAG2
0.527
2
UniProt:P35998 PSMC2
5
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [cytosol]
(R-HSA-68771)
0.527
2
UniProt:Q9BSQ5 CCM2
0.527
2
UniProt:Q96K76 USP47
1
USP47 [nucleoplasm]
(R-HSA-5696961)
0.527
2
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.527
2
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