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SUMO2(1-95) [nucleoplasm]
Stable Identifier
R-HSA-2990837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
proSUMO2, Small ubiquitin-related modifier 2, SUMO2_HUMAN, SUMO2
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
Processing and activation of SUMO (Homo sapiens)
SUMO is proteolytically processed (Homo sapiens)
SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)
SUMO2(1-95) [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61956 SUMO2
Gene Names
SUMO2, SMT3B, SMT3H2
Chain
chain:1-93, propeptide:94-95
Reference Genes
BioGPS Gene:6613 SUMO2
COSMIC (genes):SUMO2 SUMO2
CTD Gene:6613 SUMO2
dbSNP Gene:6613 SUMO2
ENSEMBL:ENSG00000188612 SUMO2
ENSEMBL_homo_sapiens_GENE:ENSG00000188612.12 SUMO2
HGNC:11125 SUMO2
KEGG Gene (Homo sapiens):6613 SUMO2
Monarch:6613 SUMO2
NCBI Gene:6613 SUMO2
OMIM:603042 SUMO2
UCSC:P61956 SUMO2
Reference Transcript
RefSeq:NM_001005849.1 SUMO2
RefSeq:NM_006937.3 SUMO2
Other Identifiers
11716369_x_at
11741526_x_at
11753750_x_at
16848755
208738_3p_x_at
208738_PM_x_at
208738_x_at
208739_PM_x_at
208739_x_at
211444_PM_at
211444_at
213881_3p_x_at
213881_PM_x_at
213881_x_at
3003031
3761609
3770624
3770625
3770633
3770634
3770635
3770636
3770637
3770638
3770641
3770642
3770643
4018870
4018872
41185_f_at
6613
8018315
8174636
8178322
A_23_P107048
A_23_P118435
A_23_P310295
A_24_P330691
GE79270
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0006351
GO:0006355
GO:0016605
GO:0016740
GO:0016925
GO:0019789
GO:0030163
GO:0031386
GO:0031625
GO:0032436
GO:0036211
GO:0043226
GO:0044389
GO:0045944
GO:0140096
HMNXSV003005390
HMNXSV003007837
Hs.180139.0.S2_3p_a_at
Hs.180139.0.S2_3p_x_at
Hs.180139.1.S1_3p_a_at
Hs.180139.1.S1_3p_x_at
ILMN_1738150
ILMN_2333594
PH_hs_0036913
TC17001873.hg
X99585_at
g12803928_3p_at
g5566605_3p_x_at
p7047
Participates
as an input of
SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)
Other forms of this molecule
lysyl-G93-SUMO2 [cytosol]
UBA2-G93-SUMO2 [nucleoplasm]
SUMO2 [nucleoplasm]
UBE2I-G93-SUMO2 [nucleoplasm]
lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]
Inferred To
Sumo [nucleoplasm]
(Drosophila melanogaster)
SUMO2 [nucleoplasm]
(Bos taurus)
SUMO2 [nucleoplasm]
(Canis familiaris)
SUMO2 [nucleoplasm]
(Gallus gallus)
SUMO2 [nucleoplasm]
(Sus scrofa)
sumo2 [nucleoplasm]
(Danio rerio)
sumo2 [nucleoplasm]
(Xenopus tropicalis)
Sumo2 [nucleoplasm]
(Mus musculus)
Sumo2 [nucleoplasm]
(Rattus norvegicus)
SUMO2(1-95) [nucleoplasm]
(Dictyostelium discoideum)
SUMO2(1-95) [nucleoplasm]
(Plasmodium falciparum)
Cross References
RefSeq
NP_001005849.1
,
NP_008868.3
OpenTargets
ENSG00000188612
GeneCards
P61956
HPA
ENSG00000188612-SUMO2
Ensembl
ENST00000420826
,
ENSG00000188612
,
ENST00000314523
,
ENSP00000400886
,
ENSP00000405965
PRO
P61956
Pharos - Targets
P61956
PDB
4NPN
,
5D2M
,
2IO0
,
2D07
,
3UIO
,
2N9E
,
2AWT
,
4BKG
,
2IO3
,
5EQL
,
2CKH
,
1WM2
,
6JXW
,
2IYD
,
1WM3
,
7ZJV
,
2N1W
,
5ELU
,
3ZO5
,
1WZ0
,
2RPQ
,
5GHB
,
6JXX
,
3UIN
,
5GHC
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46060 RANGAP1
3
RANGAP1 [nuclear envelope]
(R-HSA-167661)
monoSUMO1-K524-RANGAP1 [nuclear envelope]
(R-HSA-3000416)
RANGAP1 [cytosol]
(R-HSA-376255)
0.75
6
UniProt:Q9P0U3 SENP1
2
SENP1 [cytosol]
(R-HSA-9715128)
SENP1 [nucleoplasm]
(R-HSA-2984299)
0.743
6
UniProt:Q9HC62 SENP2
1
SENP2 [nucleoplasm]
(R-HSA-2984298)
0.719
5
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.718
6
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
UBE2I [nucleoplasm]
(R-HSA-912481)
0.688
5
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.668
3
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.592
4
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.589
2
UniProt:Q5W0Q7 USPL1
0.573
2
UniProt:Q6DRC5 USPL1
0.558
2
UniProt:Q13569 TDG
3
polySUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
monoSUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
TDG [nucleoplasm]
(R-HSA-65812)
0.558
2
UniProt:P23497-2 SP100
0.556
3
UniProt:Q8IX15-3 HOMEZ
0.556
3
UniProt:O15060 ZBT39
0.556
3
UniProt:Q86T24 KAISO
0.556
3
UniProt:Q96IT1 ZNF496
1
ZNF496 [nucleoplasm]
(R-HSA-1247860)
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.553
2
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.553
2
UniProt:O88846
1
RNF4 [cytosol]
(R-RNO-975974)
0.544
2
UniProt:P10242 MYB
1
MYB [nucleoplasm]
(R-HSA-992697)
0.544
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.508
3
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.499
3
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