Reactome | IGF2BP3 [cytosol]

IGF2BP3 [cytosol]

Stable Identifier

R-HSA-428313

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Insulin-like growth factor 2 mRNA-binding protein 3, IF2B3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00425 IGF2BP3

Gene Names

IGF2BP3, IMP3, KOC1, VICKZ3

Chain

chain:1-579

Reference Genes

BioGPS Gene:10643 IGF2BP3

COSMIC (genes):IGF2BP3 IGF2BP3

COSMIC (genes):IMP3 IMP3

CTD Gene:10643 IGF2BP3

dbSNP Gene:10643 IGF2BP3

ENSEMBL:ENSG00000136231 IGF2BP3

HGNC:28868 IGF2BP3

KEGG:hsa:10643 IGF2BP3

Monarch:10643 IGF2BP3

NCBI Entrez Gene:10643 IGF2BP3

OMIM:608259 IGF2BP3

UCSC:O00425 IGF2BP3

Reference Transcript

RefSeq:NM_006547.2 IGF2BP3

Other Identifiers

10643

11722917_s_at

11756285_s_at

1569033_3p_at

1569033_PM_at

1569033_at

17055828

203819_PM_s_at

203819_s_at

203820_3p_s_at

203820_PM_s_at

203820_s_at

216493_PM_s_at

216493_s_at

2984850

2984855

2984859

2984860

2984861

2984863

2984864

3003435

3003440

3041408

3041410

3041411

3041412

3041415

3041416

3041417

3041418

3041419

3041420

3041421

3041426

3041427

3041428

3041429

3041430

3041431

3041432

3041434

3041438

3041439

3041440

3041441

3041449

3041451

3041452

3041453

3041455

3041457

3041469

3041470

3041471

3041474

3041475

3041476

3041477

37558_at

8138566

A_23_P19987

GE54824

GE81650

GO:0000932

GO:0001817

GO:0003676

GO:0003723

GO:0003730

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006412

GO:0006417

GO:0007399

GO:0009653

GO:0010494

GO:0017148

GO:0043226

GO:0045182

GO:0048027

GO:0048856

GO:0051028

GO:0060090

GO:0070934

GO:1990247

HMNXSV003007312

HMNXSV003054316

Hs.300813.0.S1_3p_s_at

Hs.79440.0.A1_3p_a_at

Hs2.382889.1.S1_3p_x_at

ILMN_1807423

PH_hs_0027705

TC07001194.hg

U97188_at

g5729900_3p_a_at

Participates

as a component of

IGF2BP3:RNA [cytosol] (Homo sapiens)

as an input of

IGF2BP3 binds specific RNAs (Homo sapiens)

Inferred To

igf2bp3 [cytosol] (Danio rerio)

rnc1 [cytosol] (Schizosaccharomyces pombe)

imph-1 [cytosol] (Caenorhabditis elegans)

Homologues of IGF2BP3 [cytosol] (Plasmodium falciparum)

Homologues of IGF2BP3 [cytosol] (Saccharomyces cerevisiae)

IGF2BP3 [cytosol] (Bos taurus)

IGF2BP3 [cytosol] (Canis familiaris)

IGF2BP3 [cytosol] (Gallus gallus)

IGF2BP3 [cytosol] (Plasmodium falciparum)

IGF2BP3 [cytosol] (Sus scrofa)

HEK2 [cytosol] (Saccharomyces cerevisiae)

PBP2 [cytosol] (Saccharomyces cerevisiae)

Igf2bp3 [cytosol] (Mus musculus)

Igf2bp3 [cytosol] (Rattus norvegicus)

Imp [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_006538.2

ENSEMBL

ENST00000619562, ENSG00000136231, ENSP00000258729, ENST00000258729, ENSP00000480267

OpenTargets

ENSG00000136231

HPA

ENSG00000136231-IGF2BP3

GeneCards

IGF2BP3

PRO

O00425

Pharos - Targets

O00425

GlyGen

O00425

PDB

2E44, 6FQR, 6FQ1, 6GX6, 6GQE

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.643	3
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	10
UniProt:Q13148 TADBP			0.556	6
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.556	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.527	2
UniProt:Q9BTD8 RBM42	1	RBM42 [nucleoplasm] (R-HSA-9769526)	0.527	2
UniProt:Q96I51 RCC1L	1	RCC1L [mitochondrial matrix] (R-HSA-9936248)	0.527	3
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	4
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:Q96E29 MTERF3	5	MTERF3 [mitochondrial matrix] (R-HSA-9936251) Ub-MTERFD1 [mitochondrial outer membrane] (R-HSA-9843333) K48polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-5205630) K63polyUb-MTERFD1 [mitochondrial outer membrane] (R-HSA-9834044) p-S65-Ub:MTERFD1 [mitochondrial outer membrane] (R-HSA-9843337)	0.527	3
UniProt:O75127 PTCD1			0.527	3
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.527	3
UniProt:Q15434 RBMS2			0.527	2
UniProt:Q12926 ELAVL2	1	ELAVL2 [nucleoplasm] (R-HSA-8850864)	0.527	2
UniProt:O95900 TRUB2	1	TRUB2 [mitochondrial matrix] (R-HSA-9936283)	0.527	3
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	2
UniProt:Q06787 FMR1			0.527	2
UniProt:Q9Y6G3 MRPL42	1	MRPL42 [mitochondrial inner membrane] (R-HSA-5368237)	0.527	2
UniProt:P82930 MRPS34	1	MRPS34 [mitochondrial inner membrane] (R-HSA-5368186)	0.527	2
UniProt:Q9UL40 ZN346			0.527	2
UniProt:Q8TCC3 MRPL30	1	MRPL30 [mitochondrial inner membrane] (R-HSA-5368184)	0.527	2
UniProt:Q9NPE2 NGRN	1	NGRN [mitochondrial matrix] (R-HSA-9936265)	0.527	3
UniProt:Q13627 DYRK1A	1	DYRK1A [nucleoplasm] (R-HSA-1362267)	0.499	3
UniProt:Q8IYB8 SUPV3L1	1	SUPV3L1 [mitochondrial matrix] (R-HSA-429828)	0.483	2

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