Reactome | p-T286-CAMK2A [nucleoplasm]

p-T286-CAMK2A [nucleoplasm]

Stable Identifier

R-HSA-444797

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ca/Calmodulin dependent protein kinase II alpha subunit

Icon

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by MECP2 (Homo sapiens)
      - Regulation of MECP2 expression and activity (Homo sapiens)
        
        MECP2 is phosphorylated at S423 (Homo sapiens)
        
        Active CaMK IV,(CaMK II) [nucleoplasm] (Homo sapiens)
        
        CAMK2 heteromer:CALM:4xCa2+ [nucleoplasm] (Homo sapiens)
        
        CAMK2 heteromer [nucleoplasm] (Homo sapiens)
        
        p-CAMK2A, p-CAMK2B [nucleoplasm] (Homo sapiens)
        
        p-T286-CAMK2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UQM7 CAMK2A

Gene Names

CAMK2A, CAMKA, KIAA0968

Chain

chain:1-478

Reference Genes

BioGPS Gene:815 CAMK2A

COSMIC (genes):CAMK2A CAMK2A

CTD Gene:815 CAMK2A

dbSNP Gene:815 CAMK2A

ENSEMBL:ENSG00000070808 CAMK2A

ENSEMBL_homo_sapiens_GENE:ENSG00000070808.17 CAMK2A

HGNC:1460 CAMK2A

KEGG Gene (Homo sapiens):815 CAMK2A

Monarch:815 CAMK2A

NCBI Gene:815 CAMK2A

OMIM:114078 CAMK2A

UCSC:Q9UQM7 CAMK2A

Reference Transcript

RefSeq:NM_171825.2 CAMK2A

Other Identifiers

11725935_at

11725936_a_at

17001617

207613_PM_s_at

207613_s_at

213108_PM_at

213108_at

2881301

2881302

2881303

2881304

2881305

2881309

2881313

2881318

2881320

2881321

2881323

2881324

2881325

2881328

2881329

2881330

2881332

2881333

2881334

2881335

2881336

2881338

2881342

2881343

2881344

2881345

2881346

31813_at

8115122

815

A_24_P380311

A_33_P3274647

GE53630

GO:0000082

GO:0000166

GO:0000278

GO:0002376

GO:0002931

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005954

GO:0006351

GO:0006355

GO:0006468

GO:0006816

GO:0007005

GO:0010666

GO:0012501

GO:0014069

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0023052

GO:0030154

GO:0030425

GO:0030666

GO:0031410

GO:0035254

GO:0035458

GO:0036211

GO:0038166

GO:0042802

GO:0042803

GO:0042995

GO:0043005

GO:0043197

GO:0043226

GO:0045202

GO:0046427

GO:0046777

GO:0046872

GO:0046928

GO:0048168

GO:0048856

GO:0048870

GO:0051092

GO:0051346

GO:0051928

GO:0060996

GO:0061024

GO:0071346

GO:0098542

GO:0106310

GO:0140096

GO:1902108

GO:1990443

GO:2000124

GO:2001222

HMNXSV003022286

Hs.143535.1.S2_3p_at

Hs.143535.1.S2_3p_x_at

ILMN_1666445

ILMN_1838586

PH_hs_0008445

TC05001934.hg

g7706285_3p_a_at

Participates

as a member of

p-CAMK2A, p-CAMK2B [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T286-CAMK2A [plasma membrane]

p-T286-CAMK2A [endocytic vesicle membrane]

p-T286,T305,T306-CAMK2A [cytosol]

CAMK2A [cytosol]

p-T286-CAMK2A [cytosol]

Inferred To

phospho-p-T286-CAMK2A [nucleoplasm] (Bos taurus)

phospho-p-T286-CAMK2A [nucleoplasm] (Caenorhabditis elegans)

phospho-p-T286-CAMK2A [nucleoplasm] (Drosophila melanogaster)

phospho-p-T286-CAMK2A [nucleoplasm] (Rattus norvegicus)

phospho-p-T286-CAMK2A [nucleoplasm] (Sus scrofa)

p-T286-Camk2a [nucleoplasm] (Mus musculus)

phospho-CAMK2A [nucleoplasm] (Canis familiaris)

phospho-CAMK2A [nucleoplasm] (Gallus gallus)

Modified Residues

Name

O-phospho-L-threonine at 286

Coordinate

286

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_741960.1

ZINC - World Drugs

KCC2A_HUMAN

Guide to Pharmacology - Targets

1555

OpenTargets

ENSG00000070808

ZINC - FDA approved

KCC2A_HUMAN

ZINC - Substances

KCC2A_HUMAN

ZINC target

Q9UQM7

ZINC - Biogenic

KCC2A_HUMAN

PRO

Q9UQM7

PDB

6OF8, 7UJQ, 6W4P, 6X5G, 7UIQ, 7UJR, 2VZ6, 7UIR, 6VZK, 7KL2, 7REC, 3SOA, 7UJS, 6X5Q, 7UIS, 7UJP, 7KL0, 7UJT, 5IG3, 7KL1, 6W4O

ZINC - Investigational

KCC2A_HUMAN

HPA

ENSG00000070808-CAMK2A

GeneCards

Q9UQM7

Ensembl

ENSP00000500642, ENSP00000507199, ENST00000348628, ENST00000682786, ENSG00000070808, ENST00000671881, ENSP00000261793, ENSP00000500386, ENST00000672479

Pharos - Targets

Q9UQM7

ZINC - Predictions - Purchasable

KCC2A_HUMAN

Orphanet

25937

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.666	5
UniProt:Q13224 GRIN2B	6	p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) GRIN2B [transport vesicle membrane] (R-HSA-9610568) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) GRIN2B [plasma membrane] (R-HSA-419558)	0.602	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:O14494 PLPP1	1	PLPP1 [plasma membrane] (R-HSA-76106)	0.556	3
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q8N0Z6 TTC5	3	TTC5 [nucleoplasm] (R-HSA-6804264) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [platelet alpha granule membrane] (R-HSA-61489) PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.556	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P26640 VARS1	1	VARS [cytosol] (R-HSA-379648)	0.556	3
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.519	2

Cite Us!