Reactome | p-S20-MYL6 [cytosol]

p-S20-MYL6 [cytosol]

Stable Identifier

R-HSA-445778

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated Myosin light polypeptide 6, MYL6, MYL6_HUMAN

Locations in the PathwayBrowser

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Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
    - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
  - Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
    - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
      - p-S20-MYL6 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60660 MYL6

Gene Names

MYL6

Chain

initiator methionine:, chain:2-151

Reference Genes

COSMIC (genes):MYL6 MYL6

dbSNP Gene:4637 MYL6

ENSEMBL:ENSG00000092841 MYL6

Participates

as a member of

Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

Other forms of this molecule

MYL6 [cytosol]

Inferred To

phospho-Myl6 [cytosol] (Mus musculus)

phospho-Myl6 [cytosol] (Rattus norvegicus)

phospho-mlc-3 [cytosol] (Caenorhabditis elegans)

phospho-Dmel\CG34435 [cytosol] (Drosophila melanogaster)

phospho-cal-7 [cytosol] (Caenorhabditis elegans)

phospho-Dmel\CG17237 [cytosol] (Drosophila melanogaster)

phospho-mlc-6 [cytosol] (Caenorhabditis elegans)

Homologues of p-S20-MYL6 [cytosol] (Caenorhabditis elegans)

Homologues of p-S20-MYL6 [cytosol] (Drosophila melanogaster)

Homologues of p-S20-MYL6 [cytosol] (Plasmodium falciparum)

phospho-myl6 [cytosol] (Xenopus tropicalis)

phospho-p-S20-MYL6 [cytosol] (Dictyostelium discoideum)

phospho-p-S20-MYL6 [cytosol] (Drosophila melanogaster)

phospho-p-S20-MYL6 [cytosol] (Gallus gallus)

phospho-p-S20-MYL6 [cytosol] (Plasmodium falciparum)

phospho-p-S20-MYL6 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S20-MYL6 [cytosol] (Schizosaccharomyces pombe)

phospho-MYL6 [cytosol] (Bos taurus)

phospho-MYL6 [cytosol] (Sus scrofa)

phospho-mlc-5 [cytosol] (Caenorhabditis elegans)

phospho-mlc-7 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 20

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.643	6
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.642	3
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.638	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	19
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.527	3
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.527	2

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