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What is Reactome ?
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Table of Contents
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NCOA1 [nucleoplasm]
Stable Identifier
R-HSA-442496
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor coactivator 1, NCOA1_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Cytoprotection by HMOX1 (Homo sapiens)
Fatty acid ligands activate PPARA (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Heme signaling (Homo sapiens)
Expression of NPAS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Circadian Clock (Homo sapiens)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of NPAS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
RORA activates gene expression (Homo sapiens)
Expression of CPT1A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Recycling of bile acids and salts (Homo sapiens)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
CYP7B1 7-hydroxylates 25OH-CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
27-hydroxycholesterol is 7alpha-hydroxylated (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
CYP7A1 7-hydroxylates CHOL (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
Fatty acid ligands activate PPARA (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ABCA1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ABCB4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ACADM (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ACOX1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ACSL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of AGT (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ANKRD1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of APOA1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of APOA2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of APOA5 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CPT1A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CPT2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CYP1A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CYP4A11 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of CYP7A1 (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of FABP1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of FADS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of FATP1 (SLC27A1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of FHL2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Farnesyldiphosphate Farnesyltransferase (FDFT1, Squalene Synthase) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of G0S2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of GLIPR1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of GRHL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of HMGCS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of Hydroxymethylglutaryl coenzyme A synthase (HMGCS1) (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of ME1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of NPAS2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of PEX11A (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of PLIN2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of PPARA (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of RGL1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of SULT2A1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of TIAM2 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of TNFRSF21 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of TRIB3 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of TXNRD1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Expression of UGT1A9 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of NCOA1 with SUMO1 (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
PPARA:RXRA Coactivator complex [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Estrogen-responsive CTSD expression (Homo sapiens)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Homo sapiens)
NCOAs [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Estrogen-responsive TFF1 gene expression (Homo sapiens)
ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
histone acetyltransferases [nucleoplasm] (Homo sapiens)
NCOA1,NCOA3 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
HATs and coactivators are recruited to the CTSD gene (Homo sapiens)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Homo sapiens)
NCOAs [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOAs [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)
ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
histone acetyltransferases [nucleoplasm] (Homo sapiens)
NCOA1,NCOA3 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
histone acetyltransferases [nucleoplasm] (Homo sapiens)
NCOA1,NCOA3 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)
ESR1 dimer:estrogen:TFGA gene:NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 recruits EP300 to TGFA promoter (Homo sapiens)
ESR1 dimer:estrogen:TFGA gene:NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] (Homo sapiens)
ESR1 dimer:estrogen:TFGA gene:NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)
ESR1:estrogen:TFGA gene:NCOA1:EP300 [nucleoplasm] (Homo sapiens)
ESR1 dimer:estrogen:TFGA gene:NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NR1H2 and NR1H3-mediated signaling (Homo sapiens)
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis (Homo sapiens)
Expression of UGT1A3 (Homo sapiens)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux (Homo sapiens)
ABCA1 gene transcription regulated by NR1H2 or NR1H3 (Homo sapiens)
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1 recruits EP300 to the ABCA1 promoter (Homo sapiens)
EP300:NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
NCOA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15788 NCOA1
Gene Names
NCOA1, BHLHE74, SRC1
Chain
initiator methionine:1, chain:2-1441
Reference Genes
BioGPS Gene:8648 NCOA1
COSMIC (genes):NCOA1 NCOA1
CTD Gene:8648 NCOA1
dbSNP Gene:8648 NCOA1
ENSEMBL:ENSG00000084676 NCOA1
ENSEMBL:ENSG00000084676.16 NCOA1
HGNC:7668 NCOA1
KEGG Gene (Homo sapiens):8648 NCOA1
Monarch:8648 NCOA1
NCBI Gene:8648 NCOA1
OMIM:602691 NCOA1
UCSC:Q15788 NCOA1
Reference Transcript
RefSeq:XM_005264626.1 NCOA1
RefSeq:XM_017005168.1 NCOA1
RefSeq:NM_147223.2 NCOA1
RefSeq:XM_005264625.1 NCOA1
RefSeq:XM_005264628.1 NCOA1
RefSeq:NM_003743.4 NCOA1
RefSeq:XM_017005169.1 NCOA1
RefSeq:NM_147233.2 NCOA1
Other Identifiers
11721339_a_at
11721340_s_at
11721341_s_at
11721342_a_at
11721343_a_at
11728845_a_at
16877728
209105_PM_at
209105_at
209106_PM_at
209106_at
209107_PM_x_at
209107_x_at
210249_PM_s_at
210249_s_at
2473150
2473151
2473152
2473174
2473177
2473178
2473191
2473194
2473199
2473201
2473203
2473207
2473208
2473209
2473213
2473214
2473218
2473219
2473220
2473221
2473222
2473223
2473224
2473231
2473232
2473233
2473234
2473235
2473236
2473241
2473242
2473244
2473245
2473247
2473248
2473249
2473250
2473262
2473264
2473265
2473266
2473267
2473268
2473269
2473270
2473271
2473272
2473273
36118_at
484_at
65715_at
8040552
8648
A_14_P131560
A_14_P133015
A_23_P39602
A_33_P3270009
GE55134
GE85573
GO:0000435
GO:0000785
GO:0000977
GO:0002155
GO:0003677
GO:0003682
GO:0003713
GO:0003824
GO:0004402
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005829
GO:0005886
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0007595
GO:0008584
GO:0009725
GO:0012501
GO:0016071
GO:0016740
GO:0016746
GO:0016922
GO:0021549
GO:0021766
GO:0021854
GO:0021987
GO:0022414
GO:0023052
GO:0030154
GO:0030331
GO:0030374
GO:0032355
GO:0032526
GO:0032570
GO:0032870
GO:0032991
GO:0035357
GO:0042789
GO:0042974
GO:0043065
GO:0043226
GO:0044849
GO:0044877
GO:0045666
GO:0045893
GO:0045925
GO:0045944
GO:0046965
GO:0046983
GO:0048856
GO:0060179
GO:0060713
GO:0061629
GO:0090575
GO:0140096
GO:0140110
GO:1900076
GO:1904017
GO:1904179
HMNXSV003017194
Hs.74002.0.S2_3p_at
Hs.74002.0.S3_3p_at
ILMN_1669033
ILMN_1785785
ILMN_2335198
PH_hs_0024380
TC02000137.hg
U59302_at
g726037_3p_a_at
Participates
as a component of
UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand:NCOA1 [nucleoplasm] (Homo sapiens)
NCOA1:NR1H2,3:RXR:NR1H2,3 ligand:ABCA1 gene [nucleoplasm] (Homo sapiens)
ESR1 dimer:estrogen:TFGA gene:NCOA1 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm] (Homo sapiens)
as an input of
NCOA1 binds the UGT1A3 gene:NR1H2,3:RXR:NR1H2,3 ligand complex (Homo sapiens)
NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex (Homo sapiens)
NCOA1 binds ESR1:estrogen:TGFA gene (Homo sapiens)
SUMOylation of NCOA1 with SUMO1 (Homo sapiens)
NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2 (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
as a member of
NCOA1,NCOA3 [nucleoplasm] (Homo sapiens)
Coactivators of PPARalpha [nucleoplasm] (Homo sapiens)
as a candidate of
NCOAs [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
NCOA1 (868-1441) [nucleoplasm]
Inferred To
Ncoa1 [nucleoplasm]
(Mus musculus)
Ncoa1 [nucleoplasm]
(Rattus norvegicus)
NCOA1 [nucleoplasm]
(Bos taurus)
NCOA1 [nucleoplasm]
(Canis familiaris)
NCOA1 [nucleoplasm]
(Danio rerio)
NCOA1 [nucleoplasm]
(Gallus gallus)
NCOA1 [nucleoplasm]
(Sus scrofa)
ncoa1 [nucleoplasm]
(Xenopus tropicalis)
tai [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_005264682.1
,
XP_016860657.1
,
NP_671766.1
,
NP_003734.3
,
XP_005264685.1
,
NP_671756.1
,
XP_016860658.1
,
XP_005264683.1
Guide to Pharmacology - Targets
2693
OpenTargets
ENSG00000084676
ZINC - Substances
NCOA1_HUMAN
ZINC target
Q15788
PRO
Q15788
PDB
7BQ0
,
1KV6
,
5DVC
,
7XWQ
,
6L6K
,
6FO7
,
1K4W
,
4DQM
,
4G1Y
,
7WGQ
,
4MGC
,
3OOK
,
4F9M
,
1RDT
,
5Q16
,
3UUA
,
6JQ7
,
5Q1D
,
4G21
,
7CXF
,
3OMK
,
5Q10
,
5DWL
,
3HVL
,
4MG7
,
3GYT
,
3QT0
,
6A5Y
,
7KXF
,
5A86
,
6NX1
,
3ET3
,
3BQD
,
7AOS
,
5Q0L
,
7BQ1
,
4DK7
,
5Q11
,
3OLL
,
5MWP
,
1X7J
,
3IPS
,
3LMP
,
5Q1H
,
7BNU
,
7CXL
,
1XIU
,
5X8U
,
4DM8
,
5Q1I
,
6P9F
,
3RVF
,
4JYG
,
2NV7
,
5MWY
,
6U25
,
5Q0T
,
5Q1E
,
2P54
,
3DR1
,
7XVY
,
1X76
,
7JYM
,
6L96
,
7XWR
,
2FVJ
,
6ILQ
,
6HTY
,
2HFP
,
3P89
,
3FUR
,
6GG8
,
4HEE
,
3G8I
,
5Q0M
,
3UUD
,
5AVI
,
6FOB
,
1YY4
,
3S9S
,
4MGD
,
6FOD
,
6TFI
,
6A5X
,
4MG8
,
4TV1
,
5Q0Y
,
4G2H
,
3GYU
,
5Q18
,
5GTO
,
7CXH
,
3OMM
,
5YP6
,
6A60
,
5HJS
,
7B39
,
3KMR
,
3RUT
,
3T03
,
5L7E
,
5Q0Z
,
5Q0R
,
1K74
,
6SSQ
,
5NWM
,
5Q14
,
4DK8
,
3OLS
,
2NPA
,
2A3I
,
4MGA
,
7BO6
,
3OKI
,
3OMQ
,
5Q1B
,
5DV3
,
7XVZ
,
6A5Z
,
6KTM
,
4RUJ
,
1U3R
,
4G1Z
,
5NKY
,
5AVL
,
5Q0W
,
5Q0P
,
5E7V
,
7TRB
,
1X78
,
5AZT
,
5GTP
,
6GEV
,
4G1D
,
4MG9
,
7BQ2
,
4Y29
,
1ZAF
,
3FXV
,
2HCD
,
3H0A
,
1FM6
,
2PRG
,
7XWP
,
3UU7
,
7KXD
,
7BPY
,
3OOF
,
5DSH
,
5Q1C
,
3FEI
,
4JYH
,
5MX7
,
5OW7
,
7C6Q
,
7CXI
,
5YCP
,
4MG5
,
4UDA
,
1K7L
,
6W9H
,
2C52
,
7BQ3
,
6ICJ
,
3HC5
,
3G9E
,
1PZL
,
5Q12
,
3RUU
,
1NQ7
,
3VN2
,
3OMO
,
4G20
,
6W9I
,
3BEJ
,
1YYE
,
5NMB
,
5X8W
,
5Q0N
,
5Q0U
,
4MGB
,
1U3S
,
7WQQ
,
5NMA
,
5L7H
,
3V9Y
,
2HBH
,
6KTN
,
5Q15
,
7WGO
,
5X0R
,
4UDB
,
1TFC
,
7BQ4
,
1FM9
,
3OLF
,
4FGY
,
5YCN
,
5Q0X
,
5Q1F
,
3DCT
,
3DCU
,
3P88
,
7KXE
,
5Q1A
,
2GTK
,
6IJR
,
5L7G
,
7BPZ
,
5Q0K
,
1NRL
,
6A5W
,
3CWD
,
6IJS
,
6FO8
,
4TUZ
,
6BNS
,
3FEJ
,
7WGP
,
5JI0
,
6T2M
,
3IPU
,
4MG6
,
4JYI
,
5Q1G
,
7OXZ
,
3CTB
,
6E3G
,
7CXJ
,
5DV8
,
1XVP
,
1P8D
,
7CHG
,
4RUP
,
3ET1
,
6FO9
,
5DV6
,
1N4H
,
5Q0Q
,
3OKH
,
3IPQ
,
5Q0S
,
7ZFG
,
4J5X
,
3HC6
,
6ITM
,
3OMP
,
6XP9
,
1XV9
,
7CXK
,
7BNS
,
1X7B
,
5Q13
,
2HC4
,
5OW9
,
4DM6
,
7OY4
,
5JMM
,
5OWD
,
5GTN
,
5Y44
,
7QPI
,
5Q0V
,
5Q0O
,
5Q0J
,
5Q19
,
7ZFX
,
6JNR
HPA
ENSG00000084676-NCOA1
GeneCards
Q15788
Ensembl
ENST00000395856
,
ENSP00000288599
,
ENST00000348332
,
ENST00000405141
,
ENSG00000084676
,
ENSP00000385097
,
ENSP00000320940
,
ENST00000406961
,
ENST00000288599
,
ENSP00000385216
,
ENSP00000379197
Pharos - Targets
Q15788
Orphanet
25753
ZINC - Predictions - Purchasable
NCOA1_HUMAN
HMDB Protein
HMDBP00039
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.869
7
UniProt:P19793 RXRA
4
RXRA [cytosol]
(R-HSA-9619757)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
RXRA [nucleoplasm]
(R-HSA-381319)
0.857
14
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.835
8
UniProt:Q13133 NR1H3
1
NR1H3 [nucleoplasm]
(R-HSA-8854957)
0.691
15
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.669
4
UniProt:P11473 VDR
2
polySUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
VDR [nucleoplasm]
(R-HSA-375512)
0.656
3
UniProt:P19785
11
phospho-Esr1 [nucleoplasm]
(R-MMU-9024210)
Esr1 [nucleoplasm]
(R-MMU-4090302)
Esr1 [cytosol]
(R-MMU-9020974)
Esr1 [cytosol]
(R-MMU-9020991)
Esr1 [plasma membrane]
(R-MMU-9021057)
Esr1 [plasma membrane]
(R-MMU-9021053)
Esr1 [plasma membrane]
(R-MMU-9637788)
Esr1 [plasma membrane]
(R-MMU-9637786)
Esr1 [cytosol]
(R-MMU-9020968)
Esr1 [nucleoplasm]
(R-MMU-446168)
Esr1 [cytosol]
(R-MMU-9632177)
0.646
3
UniProt:Q9BTK6 PAGR1
1
PAGR1 [nucleoplasm]
(R-HSA-5619374)
0.625
4
ChEBI:36274 GLYCOCHENODEOXYCHOLIC ACID
0.623
2
ChEBI:16755 CHENODEOXYCHOLIC ACID
0.623
2
UniProt:Q96RI1-2 NR1H4
2
SUMO1-K132,K289-NR1H4 [nucleoplasm]
(R-HSA-4755487)
NR1H4-2 [nucleoplasm]
(R-HSA-3196161)
0.623
5
taurochenodeoxycholic acid [ChEBI:16525]
2
taurochenodeoxycholate [peroxisomal matrix]
(R-ALL-193484)
TCDCA [cytosol]
(R-ALL-159422)
0.623
2
UniProt:O75469 NR1I2
0.602
5
UniProt:Q63ZY3 KANK2
0.59
4
UniProt:P28065 PSMB9
2
PSMB9 [nucleoplasm]
(R-HSA-174334)
PSMB9 [cytosol]
(R-HSA-68765)
0.581
3
UniProt:Q13569 TDG
3
polySUMO2,3-K330-TDG [nucleoplasm]
(R-HSA-4551628)
monoSUMO1-K330-TDG [nucleoplasm]
(R-HSA-4551718)
TDG [nucleoplasm]
(R-HSA-65812)
0.576
8
UniProt:Q96RI1 NR1H4
1
NR1H4 [nucleoplasm]
(R-HSA-5340228)
0.558
4
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:P59598
1
Asxl1 [nucleoplasm]
(R-MMU-5689645)
0.544
2
UniProt:P06536
10
Nr3c1 [nucleoplasm]
(R-RNO-4341106)
Nr3c1 [cytosol]
(R-RNO-5618118)
Nr3c1 [nucleoplasm]
(R-RNO-3196175)
Nr3c1 [nucleoplasm]
(R-RNO-3196163)
Nr3c1 [nucleoplasm]
(R-RNO-3196152)
Nr3c1 [nucleoplasm]
(R-RNO-3196155)
Nr3c1 [nucleoplasm]
(R-RNO-3196158)
Nr3c1 [nucleoplasm]
(R-RNO-3196159)
Nr3c1 [nucleoplasm]
(R-RNO-3196167)
Nr3c1 [nucleoplasm]
(R-RNO-3196173)
0.524
2
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.524
4
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
0.519
2
UniProt:P25799
8
phospho-Nfkb1 [cytosol]
(R-MMU-451619)
phospho-Nfkb1 [cytosol]
(R-MMU-451611)
Nfkb1 [cytosol]
(R-MMU-451607)
Nfkb1 [nucleoplasm]
(R-MMU-177655)
Nfkb1 [cytosol]
(R-MMU-168168)
Nfkb1 [specific granule lumen]
(R-MMU-6799557)
Nfkb1 [extracellular region]
(R-MMU-6806304)
Nfkb1 [secretory granule lumen]
(R-MMU-6801004)
0.508
2
UniProt:PGR ENSG00000082175
0.499
2
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