Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MTA2 [nucleoplasm]
Stable Identifier
R-HSA-4657009
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Metastasis-associated protein MTA2, MTA2_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423 (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
ZNF423 recruits NuRD to EBF2 target genes (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2,EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, UCP1 gene, (CIDEA gene, DIO2 gene) [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9 (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by KRAB-ZFP proteins (Homo sapiens)
NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
NuRD:SUMO2-6K-TRIM28:KRAB-ZNF:retroelement chromatin [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (Homo sapiens)
DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
MTA2-NuRD complex [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
SALL4:NuRD:PTEN gene [nucleoplasm] (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
SALL4 recruits NuRD to PTEN gene (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
SALL4:NuRD:PTEN gene [nucleoplasm] (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
MTA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94776 MTA2
Gene Names
MTA2, MTA1L1, PID
Chain
chain:1-668
Reference Genes
BioGPS Gene:9219 MTA2
COSMIC (genes):MTA2 MTA2
CTD Gene:9219 MTA2
dbSNP Gene:9219 MTA2
ENSEMBL:ENSG00000149480 MTA2
HGNC:7411 MTA2
KEGG:hsa:9219 MTA2
Monarch:9219 MTA2
NCBI Gene:9219 MTA2
OMIM:603947 MTA2
UCSC:O94776 MTA2
Reference Transcript
RefSeq:NM_001330292.1 MTA2
RefSeq:NM_004739.3 MTA2
Other Identifiers
11748470_a_at
11756265_a_at
16739317
203444_PM_s_at
203444_s_at
3375863
3375864
3375865
3375866
3375867
3375868
3375869
3375870
3375871
3375872
3375873
3375874
3375875
3375876
3375877
3375878
3375879
3375880
3375881
3375882
3375883
3375884
3375885
3375886
3375887
3375888
3375889
3375890
3375891
3375893
3375895
7948696
9219
A_23_P203420
GE53326
GO:0000118
GO:0000122
GO:0000781
GO:0000785
GO:0003677
GO:0003682
GO:0003712
GO:0003713
GO:0003714
GO:0003824
GO:0004407
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0006325
GO:0006338
GO:0006355
GO:0010762
GO:0016020
GO:0016581
GO:0016787
GO:0031492
GO:0032991
GO:0042659
GO:0042826
GO:0043226
GO:0043565
GO:0045892
GO:0045893
GO:0045944
GO:0046872
GO:0060090
GO:0061629
GO:0071514
GO:0140096
GO:0140110
GO:2000736
HMNXSV003018724
HMNXSV003031981
ILMN_1772644
ILMN_1773763
PH_hs_0010371
TC11001870.hg
g4758739_3p_a_at
Participates
as a component of
MTA2-NuRD complex [nucleoplasm] (Homo sapiens)
as a member of
MTA1, MTA2, MTA3 [nucleoplasm] (Homo sapiens)
Inferred To
Mta2 [nucleoplasm]
(Mus musculus)
Mta2 [nucleoplasm]
(Rattus norvegicus)
MTA1-like [nucleoplasm]
(Drosophila melanogaster)
lin-40 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of MTA2 [nucleoplasm]
(Xenopus tropicalis)
MTA2 [nucleoplasm]
(Bos taurus)
MTA2 [nucleoplasm]
(Canis familiaris)
MTA2 [nucleoplasm]
(Gallus gallus)
MTA2 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_001317221.1
,
NP_004730.2
ENSEMBL
ENSP00000431346
,
ENSP00000278823
,
ENSP00000431797
,
ENST00000278823
,
ENST00000527204
,
ENST00000524902
OpenTargets
ENSG00000149480
HPA
ENSG00000149480-MTA2
PRO
O94776
Pharos - Targets
O94776
GlyGen
O94776
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.951
19
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.911
14
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.877
9
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.877
11
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.677
7
UniProt:Q9BZR8 BCL2L14
1
BCL2L14 [cytosol]
(R-HSA-6791317)
0.643
3
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.63
6
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.597
4
UniProt:O60315 ZEB2
1
ZEB2 [nucleoplasm]
(R-HSA-3108222)
0.577
4
UniProt:Q12873 CHD3
2
CHD3 [nucleoplasm]
(R-HSA-4657012)
monoSUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
0.577
5
UniProt:Q99497 PARK7
7
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
PARK7 [nucleoplasm]
(R-HSA-3900141)
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
0.576
3
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.527
2
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.527
2
UniProt:Q9UKG1 APPL1
1
APPL1 [endosome membrane]
(R-HSA-373630)
0.462
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.462
5
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text