Reactome | APPL1 [endosome membrane]

APPL1 [endosome membrane]

Stable Identifier

R-HSA-373630

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

DCC-interacting protein 13-alpha, DP13A_HUMAN

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External Reference Information

External Reference

UniProt:Q9UKG1 APPL1

Gene Names

APPL1, APPL, DIP13A, KIAA1428

Chain

chain:1-709

Reference Genes

BioGPS Gene:26060 APPL1

COSMIC (genes):APPL1 APPL1

CTD Gene:26060 APPL1

dbSNP Gene:26060 APPL1

ENSEMBL:ENSG00000157500 APPL1

ENSEMBL_homo_sapiens_GENE:ENSG00000157500.12 APPL1

HGNC:24035 APPL1

KEGG Gene (Homo sapiens):26060 APPL1

Monarch:26060 APPL1

NCBI Gene:26060 APPL1

OMIM:604299 APPL1

UCSC:Q9UKG1 APPL1

Reference Transcript

RefSeq:NM_012096.2 APPL1

Other Identifiers

11722730_at

11722731_a_at

11722732_at

11722733_x_at

11722734_at

11722735_at

11722736_s_at

11722737_at

16942003

218158_PM_s_at

218158_s_at

222538_PM_s_at

222538_s_at

26060

2625607

2625608

2625609

2625615

2625616

2625617

2625619

2625621

2625622

2625623

2625624

2625626

2625627

2625628

2625629

2625631

2625632

2625633

2625634

2625636

2625637

2625638

2625640

2625643

2625645

2625647

2625648

2625649

2625650

2625651

2625652

43163_at

44007_at

48395_at

52982_at

62326_at

8080645

91217_at

A_14_P103400

A_14_P124830

A_14_P200098

A_23_P166663

A_24_P302833

GE58456

GO:0000278

GO:0001726

GO:0001786

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006606

GO:0006886

GO:0006913

GO:0006954

GO:0007049

GO:0007165

GO:0007179

GO:0008092

GO:0008286

GO:0008289

GO:0010008

GO:0010762

GO:0012506

GO:0016020

GO:0016192

GO:0023052

GO:0031410

GO:0031901

GO:0032009

GO:0033211

GO:0034143

GO:0034330

GO:0035091

GO:0035729

GO:0042802

GO:0042803

GO:0042995

GO:0043226

GO:0043422

GO:0044354

GO:0044877

GO:0045088

GO:0045335

GO:0046324

GO:0046326

GO:0048023

GO:0048487

GO:0048870

GO:0055085

GO:0070062

GO:0072659

GO:0097708

GO:0098542

GO:0098793

GO:0098794

GO:0098978

GO:0099558

GO:1900017

GO:1903076

GO:1905303

GO:1905450

GO:2000045

HMNXSV003033576

Hs.27413.0.S1_3p_a_at

ILMN_1763730

PH_hs_0002433

TC03000365.hg

TC03002354.hg

g6912241_3p_a_at

Participates

as an input of

DCC interacts with DIP13alpha (Homo sapiens)

as a component of

DCC:DIP13alpha [plasma membrane] (Homo sapiens)

Inferred To

Appl1 [endosome membrane] (Mus musculus)

Appl1 [endosome membrane] (Rattus norvegicus)

APPL1 [endosome membrane] (Bos taurus)

APPL1 [endosome membrane] (Canis familiaris)

APPL1 [endosome membrane] (Sus scrofa)

Cross References

RefSeq

NP_036228.1

OpenTargets

ENSG00000157500

GeneCards

Q9UKG1

HPA

ENSG00000157500-APPL1

Ensembl

ENSP00000288266, ENST00000650354, ENSG00000157500, ENSP00000498115, ENST00000288266

PRO

Q9UKG1

Pharos - Targets

Q9UKG1

Orphanet

23347

PDB

2Q12, 2EJ8, 2ELB, 2Z0O, 2Q13, 2Z0N, 5C5B, 2ELA

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NEU8 DP13B			0.964	23
UniProt:Q9UKG1 APPL1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.95	16
UniProt:P20339 RAB5A	7	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-HSA-8871125) GGC-RAB5A [early endosome membrane] (R-HSA-8875323) GGC-RAB5A [cytosol] (R-HSA-8870432) RAB5A [early endosome membrane] (R-HSA-2130175) RAB5A [cytosol] (R-HSA-2201187) GGC-RAB5A [macropinosome membrane] (R-HSA-9837697) RAB5A [endosome membrane] (R-HSA-452257)	0.841	23
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.781	9
UniProt:P43362 MAGA9			0.743	5
UniProt:Q9C0C9 UBE2O	1	UBE2O [cytosol] (R-HSA-947641)	0.718	6
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.653	3
UniProt:Q96NB3 ZNF830	1	ZNF830 [nucleoplasm] (R-HSA-6781962)	0.589	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.571	3
UniProt:Q9Y3I0 RTCB	1	RTCB [nucleoplasm] (R-HSA-5696792)	0.57	3
UniProt:P18066	5	GGC-RAB5A [clathrin-coated endocytic vesicle membrane] (R-CFA-8871125) GGC-RAB5A [early endosome membrane] (R-CFA-8875323) GGC-RAB5A [cytosol] (R-CFA-8870432) RAB5A [endosome membrane] (R-CFA-452257) RAB5A [cytosol] (R-CFA-2201187)	0.557	4
UniProt:Q8TAI7 REBL1			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:Q9BV57 ADI1	1	ADI1 [cytosol] (R-HSA-1237109)	0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:Q96A54 ADIPOR1	1	ADIPOR1 [plasma membrane] (R-HSA-8848544)	0.553	6
UniProt:Q01968 OCRL	4	OCRL [Golgi membrane] (R-HSA-434339) OCRL [cytoplasmic vesicle membrane] (R-HSA-434214) OCRL [plasma membrane] (R-HSA-3769049) OCRL [cytosol] (R-HSA-1806196)	0.534	2
UniProt:Q96KS9 F167A			0.527	3
UniProt:Q8NHX9 TPCN2	1	TPCN2 [lysosomal membrane] (R-HSA-2685518)	0.527	2
UniProt:Q8TF65 GIPC2			0.527	2
UniProt:Q92769 HDAC2	2	monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958) HDAC2 [nucleoplasm] (R-HSA-205135)	0.527	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.519	2
UniProt:Q91VH1	1	ADIPOR1 [plasma membrane] (R-MMU-8848544)	0.508	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.499	2
UniProt:Q8NBZ0 INO80E	1	INO80E [nucleoplasm] (R-HSA-5689552)	0.488	2
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.488	2
UniProt:P27986-2 PIK3R1			0.488	2
UniProt:Q9NR55 BATF3			0.488	2
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.488	2
UniProt:Q8TD91-2 MAGEC3			0.488	2
UniProt:Q7L591-3 DOK3			0.488	2
UniProt:Q3KNS6 ZN829			0.488	2
UniProt:Q9H8W4 PKHF2			0.488	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.488	2
UniProt:O14544 SOCS6	1	SOCS6 [cytosol] (R-HSA-1469969)	0.488	2
UniProt:Q9NSI6-4 BRWD1			0.488	2
UniProt:Q18PE1 DOK7			0.488	2
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.488	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.488	2
UniProt:P41134 ID1	1	ID1 [nucleoplasm] (R-HSA-2534101)	0.488	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.483	2
UniProt:O14908 GIPC1	1	GIPC1 [cytoplasm] (R-HSA-9839329)	0.483	3
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.462	3
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.462	3
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.454	2
UniProt:Q8WXH0 SYNE2	1	SYNE2 [nuclear envelope] (R-HSA-912404)	0.454	3
UniProt:Q03001 DST	1	DST [plasma membrane] (R-HSA-447008)	0.454	3
UniProt:O75923 DYSF	1	DYSF [cytoplasmic vesicle membrane] (R-HSA-5263626)	0.454	2

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