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PolyUb-CDC20 [nucleoplasm]
Stable Identifier
R-HSA-6783069
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP44 deubiquitinates CDC20 (Homo sapiens)
USP44:PolyUb-CDC20 [nucleoplasm] (Homo sapiens)
PolyUb-CDC20 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12834 CDC20
Gene Names
CDC20
Chain
chain:1-499
Reference Genes
BioGPS Gene:991 CDC20
COSMIC (genes):CDC20 CDC20
CTD Gene:991 CDC20
dbSNP Gene:991 CDC20
ENSEMBL:ENSG00000117399 CDC20
HGNC:1723 CDC20
KEGG:hsa:991 CDC20
Monarch:991 CDC20
NCBI Gene:991 CDC20
OMIM:603618 CDC20
UCSC:Q12834 CDC20
Reference Transcript
RefSeq:NM_001255.2 CDC20
Other Identifiers
11717163_s_at
11748314_a_at
16663514
202870_PM_s_at
202870_s_at
2332908
2333137
2333138
2333139
2333140
2333142
2333143
2333144
2333145
2333146
2333147
2333148
2333149
2333150
2333151
2333152
2333153
2333154
2333155
2333156
2333157
2333158
2333159
2333160
2333162
2333163
3177818
3177820
38414_at
7900699
991
A_14_P102603
A_14_P107876
A_23_P149200
GE58880
GO:0000775
GO:0000776
GO:0000922
GO:0005515
GO:0005654
GO:0005680
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0007010
GO:0007064
GO:0007094
GO:0007346
GO:0007399
GO:0010997
GO:0016567
GO:0022414
GO:0030154
GO:0030163
GO:0031145
GO:0031915
GO:0033597
GO:0040020
GO:0043226
GO:0044784
GO:0045842
GO:0048856
GO:0051301
GO:0051445
GO:0060090
GO:0090129
GO:0090307
GO:0097027
GO:0098772
GO:1904668
GO:1905786
GO:1990756
GO:1990757
GO:1990949
HMNXSV003046343
ILMN_1663390
TC01000545.hg
U05340_at
g4557436_3p_s_at
Participates
as a component of
USP44:PolyUb-CDC20 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CDC20 [cytosol]
CDC20 [nucleoplasm]
Inferred To
CDC20 [nucleoplasm]
(Bos taurus)
CDC20 [nucleoplasm]
(Canis familiaris)
CDC20 [nucleoplasm]
(Gallus gallus)
CDC20 [nucleoplasm]
(Sus scrofa)
fzy-1 [nucleoplasm]
(Caenorhabditis elegans)
Cdc20 [nucleoplasm]
(Mus musculus)
Cdc20 [nucleoplasm]
(Rattus norvegicus)
cdc20 [nucleoplasm]
(Danio rerio)
cdc20 [nucleoplasm]
(Dictyostelium discoideum)
cdc20 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position
Modification
PolyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001246.2
OpenTargets
ENSG00000117399
ENSEMBL
ENSP00000361540
,
ENSP00000308450
,
ENST00000310955
,
ENST00000372462
HPA
ENSG00000117399-CDC20
PRO
Q12834
Pharos - Targets
Q12834
GlyGen
Q12834
PDB
5KHR
,
4GGC
,
6F0X
,
5KHU
,
4N14
,
4GGA
,
6Q6H
,
5G04
,
6Q6G
,
5LCW
,
4GGD
Interactors (38)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13257 MAD2L1
2
Activated MAD2L1 [cytosol]
(R-HSA-141447)
MAD2L1 [cytosol]
(R-HSA-141400)
0.982
38
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.975
38
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.942
14
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [cytosol]
(R-HSA-174168)
ANAPC4 [nucleoplasm]
(R-HSA-174115)
0.794
10
UniProt:Q96DE5 ANAPC16
2
ANAPC16 [cytosol]
(R-HSA-6805138)
ANAPC16 [nucleoplasm]
(R-HSA-6805137)
0.725
5
UniProt:Q13042 CDC16
2
CDC16 [cytosol]
(R-HSA-174156)
CDC16 [nucleoplasm]
(R-HSA-174049)
0.708
5
UniProt:Q9Y2Z4 YARS2
1
YARS2 [mitochondrial matrix]
(R-HSA-379634)
0.669
4
UniProt:Q9UJX6 ANAPC2
2
ANAPC2 [cytosol]
(R-HSA-174229)
ANAPC2 [nucleoplasm]
(R-HSA-174141)
0.648
3
UniProt:O43683 BUB1
1
BUB1 [cytosol]
(R-HSA-377888)
0.643
3
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.643
4
UniProt:P20248 CCNA2
3
CCNA2 [nucleoplasm]
(R-HSA-68905)
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
0.643
6
UniProt:P24941 CDK2
5
p-T160-CDK2 [nucleoplasm]
(R-HSA-187967)
CDK2 [nucleoplasm]
(R-HSA-68365)
CDK2 [cytosol]
(R-HSA-157440)
p-CDK2 [nucleoplasm]
(R-HSA-68370)
p-Y15-CDK2 [nucleoplasm]
(R-HSA-187905)
0.643
4
UniProt:Q9UM13 ANAPC10
2
ANAPC10 [cytosol]
(R-HSA-174142)
ANAPC10 [nucleoplasm]
(R-HSA-174047)
0.621
7
UniProt:Q8R349
2
Cdc16 [nucleoplasm]
(R-MMU-174049)
Cdc16 [cytosol]
(R-MMU-174156)
0.564
3
UniProt:Q99JP4
2
Cdc26 [nucleoplasm]
(R-MMU-174216)
Cdc26 [cytosol]
(R-MMU-174052)
0.564
3
UniProt:Q8BGZ4
2
Cdc23 [nucleoplasm]
(R-MMU-174228)
Cdc23 [cytosol]
(R-MMU-174137)
0.564
4
UniProt:Q9Z1B5
1
Mad2l1 [cytosol]
(R-MMU-141400)
0.564
2
UniProt:Q9CPV2
2
Anapc16 [nucleoplasm]
(R-MMU-6805137)
Anapc16 [cytosol]
(R-MMU-6805138)
0.564
3
UniProt:Q9Z1S0
1
BUB1B [cytosol]
(R-MMU-141436)
0.564
2
UniProt:Q8IXJ6-2 SIRT2
0.544
2
UniProt:O43684 BUB3
1
BUB3 [cytosol]
(R-HSA-141416)
0.527
2
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.527
3
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.527
3
UniProt:Q8NHZ8 CDC26
2
CDC26 [cytosol]
(R-HSA-174052)
CDC26 [nucleoplasm]
(R-HSA-174216)
0.527
3
UniProt:Q9UJX4 ANAPC5
2
ANAPC5 [cytosol]
(R-HSA-174211)
ANAPC5 [nucleoplasm]
(R-HSA-174153)
0.527
4
UniProt:P13489 RINI
0.527
3
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.527
3
UniProt:O60232 ZNRD2
0.527
2
UniProt:Q15013 MD2BP
0.527
4
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.527
3
UniProt:P38936 CDKN1A
5
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
CDKN1A [cytosol]
(R-HSA-182512)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
3
UniProt:P60006 ANAPC15
2
ANAPC15 [cytosol]
(R-HSA-6805140)
ANAPC15 [nucleoplasm]
(R-HSA-6805136)
0.527
2
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.524
2
UniProt:Q8VDQ8
1
SIRT2 [cytosol]
(R-MMU-2161118)
0.499
3
UniProt:Q13257-1 MAD2L1
0.488
14
UniProt:Q15013-1 MAD2L1BP
0.488
12
UniProt:Q15645-1 TRIP13
0.488
4
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