p-S2,S7(CTD)-POLR2A [nucleoplasm]

Stable Identifier
R-HSA-6814543
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
RNA Pol II (Ser2,7 phosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1
Locations in the PathwayBrowser
General
The C-terminal domain (CTD) of POLR2A contains about 52 repeats of the consensus heptad YSPTSPS. Serines-2,5, and 7 of the heptads are phosphorylated in RNA polymerase II initiating transcription of snRNA genes. The exact repeats that are phosphorylated are not known.
Literature References
PubMed ID Title Journal Year
16012166 Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans

Schwinn, DA, Michelotti, GA, Morris, DP

J. Biol. Chem. 2005
Participates
Other forms of this molecule
Inferred To
Modified Residues
Name
O-phospho-L-serine at 1845
Coordinate
1845
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1847
Coordinate
1847
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1861
Coordinate
1861
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1868
Coordinate
1868
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1875
Coordinate
1875
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1882
Coordinate
1882
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1889
Coordinate
1889
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1896
Coordinate
1896
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1910
Coordinate
1910
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1917
Coordinate
1917
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1924
Coordinate
1924
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1931
Coordinate
1931
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
GeneCards
PRO
Pharos - Targets
HMDB Protein
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