p-S2,S7(CTD)-POLR2A [nucleoplasm]

Stable Identifier
R-HSA-6814543
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RNA Pol II (Ser2,7 phosphorylated) largest subunit, DNA-directed RNA polymerase II largest subunit , RPB1
Locations in the PathwayBrowser
Expand all
General
The C-terminal domain (CTD) of POLR2A contains about 52 repeats of the consensus heptad YSPTSPS. Serines-2,5, and 7 of the heptads are phosphorylated in RNA polymerase II initiating transcription of snRNA genes. The exact repeats that are phosphorylated are not known.
Literature References
PubMed ID Title Journal Year
16012166 Evidence that phosphorylation of the RNA polymerase II carboxyl-terminal repeats is similar in yeast and humans

Schwinn, DA, Michelotti, GA, Morris, DP

J. Biol. Chem. 2005
External Reference Information
External Reference
UniProt:P24928 POLR2A
Gene Names
POLR2A, POLR2
Chain
chain:1-1970
Reference Genes
BioGPS Gene:5430 POLR2A
COSMIC (genes):POLR2A POLR2A
CTD Gene:5430 POLR2A
dbSNP Gene:5430 POLR2A
ENSEMBL:ENSG00000181222 POLR2A
HGNC:9187 POLR2A
KEGG Gene (Homo sapiens):5430 POLR2A
Monarch:5430 POLR2A
NCBI Gene:5430 POLR2A
OMIM:180660 POLR2A
UCSC:P24928 POLR2A
Reference Transcript
Participates
as a component of
Other forms of this molecule
p-S5,S7(CTD)-POLR2A [nucleoplasm]
p-S5(CTD)-POLR2A [nucleoplasm]
Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm]
p-3S-POLR2A [nucleoplasm]
p-S2,S5(CTD)-POLR2A [nucleoplasm]
POLR2A [nucleoplasm]
Inferred To
Ghost homologue of p-S2,S7(CTD)-POLR2A [nucleoplasm] (Danio rerio)
Ghost homologue of p-S2,S7(CTD)-POLR2A [nucleoplasm] (Gallus gallus)
Ghost homologue of p-S2,S7(CTD)-POLR2A [nucleoplasm] (Xenopus tropicalis)
phospho-POLR2A [nucleoplasm] (Canis familiaris)
phospho-POLR2A [nucleoplasm] (Sus scrofa)
phospho-p-S2,S7(CTD)-POLR2A [nucleoplasm] (Bos taurus)
phospho-p-S2,S7(CTD)-POLR2A [nucleoplasm] (Caenorhabditis elegans)
phospho-p-S2,S7(CTD)-POLR2A [nucleoplasm] (Dictyostelium discoideum)
phospho-p-S2,S7(CTD)-POLR2A [nucleoplasm] (Drosophila melanogaster)
phospho-p-S2,S7(CTD)-POLR2A [nucleoplasm] (Mus musculus)
phospho-Polr2a [nucleoplasm] (Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 1845
Coordinate
1845
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1847
Coordinate
1847
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1861
Coordinate
1861
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1868
Coordinate
1868
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1875
Coordinate
1875
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1882
Coordinate
1882
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1889
Coordinate
1889
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1896
Coordinate
1896
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1910
Coordinate
1910
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1917
Coordinate
1917
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1924
Coordinate
1924
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 1931
Coordinate
1931
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
OpenTargets
GeneCards
PRO
Pharos - Targets
HMDB Protein
PDB
Interactors (21)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:O00267 SUPT5H  1 0.836 6
 UniProt:P19388 POLR2E  2 0.793 7
 UniProt:P23193 TCEA1  1 0.708 5
 UniProt:Q6P1J9 CDC73  1 0.708 6
 UniProt:Q8IXW5 RPAP2  1 0.643 4
 UniProt:P61218 POLR2F  2 0.643 5
 UniProt:Q9UBK9 UXT  1 0.643 3
 UniProt:P17844 DDX5  4 0.641 3
 UniProt:Q9Y5B0 CTDP1  1 0.564 2
 UniProt:O14744 PRMT5  3 0.558 6
 UniProt:Q9Y3C7 MED31  1 0.527 2
 UniProt:Q9BTT4 MED10  1 0.527 3
 UniProt:Q08945 SSRP1  1 0.527 2
 UniProt:O00308 WWP2  1 0.527 3
 UniProt:Q9H3P2 NELFA  1 0.527 2
 UniProt:P25963 NFKBIA  9 0.527 2
 UniProt:P01106 MYC  2 0.527 4
 UniProt:O95402 MED26  1 0.527 8
 UniProt:Q03468 ERCC6  2 0.499 2
 UniProt:Q9NPJ6 MED4  1 0.483 2
 UniProt:Q9H944 MED20  1 0.483 2
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