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MED4 [nucleoplasm]
Stable Identifier
R-HSA-350263
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MED4_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
ARC coactivator complex [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
DRIP coactivator complex [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Formation of TRAP coactivator complex (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
TRAP coactivator complex [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPJ6 MED4
Gene Names
MED4, ARC36, DRIP36, VDRIP, HSPC126
Chain
initiator methionine:1, chain:2-270
Reference Genes
BioGPS Gene:29079 MED4
COSMIC (genes):MED4 MED4
CTD Gene:29079 MED4
dbSNP Gene:29079 MED4
ENSEMBL:ENSG00000136146.15 MED4
HGNC:17903 MED4
KEGG Gene (Homo sapiens):29079 MED4
Monarch:29079 MED4
NCBI Gene:29079 MED4
OMIM:605718 MED4
UCSC:Q9NPJ6 MED4
Reference Transcript
RefSeq:NM_001270629.1 MED4
RefSeq:NM_014166.3 MED4
Other Identifiers
0000840204
11720497_at
11758836_at
16778987
217843_PM_s_at
217843_s_at
222438_PM_at
222438_at
29079
3513401
3513402
3513403
3513404
3513408
3513411
3513413
3513414
3513415
3513416
3513419
3513420
60538_at
78692_at
7971550
A_23_P128543
A_33_P3369766
GE61653
GO:0003712
GO:0003713
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0006351
GO:0006354
GO:0006355
GO:0006357
GO:0006366
GO:0016020
GO:0016592
GO:0030374
GO:0032968
GO:0032991
GO:0042809
GO:0043226
GO:0045893
GO:0046966
GO:0051123
GO:0060261
GO:0065003
GO:0070847
HMNXSV003040949
Hs.181112.0.A3_3p_at
ILMN_1664641
PH_hs_0010716
TC13000653.hg
TC13001486.hg
g7661787_3p_a_at
Participates
as a component of
TRAP coactivator complex [nucleoplasm] (Homo sapiens)
DRIP coactivator complex [nucleoplasm] (Homo sapiens)
ARC coactivator complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
as an input of
Formation of TRAP coactivator complex (Homo sapiens)
Formation of DRIP coactivator complex (Homo sapiens)
Formation of ARC coactivator complex (Homo sapiens)
Inferred To
cryba4 [nucleoplasm]
(Xenopus tropicalis)
med4 [nucleoplasm]
(Danio rerio)
MED4 [nucleoplasm]
(Bos taurus)
MED4 [nucleoplasm]
(Canis familiaris)
MED4 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_054885.1
,
NP_001257558.1
OpenTargets
ENSG00000136146
HPA
ENSG00000136146-MED4
GeneCards
Q9NPJ6
Ensembl
ENSP00000258648
,
ENST00000378586
,
ENSP00000367849
,
ENST00000258648
,
ENSG00000136146
PRO
Q9NPJ6
Pharos - Targets
Q9NPJ6
PDB
7NVR
,
7ENC
,
7ENJ
,
7LBM
,
7ENA
,
7EMF
Interactors (61)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.837
7
UniProt:Q9NWA0 MED9
1
MED9 [nucleoplasm]
(R-HSA-556804)
0.82
12
UniProt:A0JLT2 MED19
1
MED19 [nucleoplasm]
(R-HSA-556819)
0.802
6
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.802
8
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.794
8
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.786
11
UniProt:O95379 TNFAIP8
1
TNFAIP8 [cytosol]
(R-HSA-8874463)
0.781
7
UniProt:Q13503 MED21
1
MED21 [nucleoplasm]
(R-HSA-212456)
0.763
5
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.727
8
UniProt:Q8TD31-3 CCHCR1
0.718
6
UniProt:Q8N6Y0 USBP1
0.718
6
UniProt:Q96GM5 SMARCD1
1
SMARCD1 [nucleoplasm]
(R-HSA-389255)
0.718
6
UniProt:Q99909 SSX3
0.718
6
UniProt:Q9BUE0 MED18
1
MED18 [nucleoplasm]
(R-HSA-556826)
0.671
4
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.671
5
UniProt:Q9BWU1 CDK19
1
CDK19 [nucleoplasm]
(R-HSA-556782)
0.669
3
UniProt:Q8N3L3 TXLNB
0.666
4
UniProt:Q8IY31 IFT20
3
IFT20 [cilium]
(R-HSA-5617624)
IFT20 [Golgi membrane]
(R-HSA-5617625)
IFT20 [ciliary tip]
(R-HSA-5625355)
0.666
4
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.666
4
UniProt:O14777 NDC80
1
NDC80 [cytosol]
(R-HSA-375314)
0.659
4
UniProt:Q96CS2 HAUS1
1
HAUS1 [cytosol]
(R-HSA-8855199)
0.659
4
UniProt:Q9NX70 MED29
1
MED29 [nucleoplasm]
(R-HSA-556821)
0.643
3
UniProt:O43513 MED7
1
MED7 [nucleoplasm]
(R-HSA-212430)
0.643
3
UniProt:Q15154 PCM1
1
PCM1 [cytosol]
(R-HSA-380308)
0.598
4
UniProt:Q9ULK4 MED23
1
MED23 [nucleoplasm]
(R-HSA-556823)
0.569
6
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.569
3
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.569
3
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.556
3
UniProt:P48232 SNAPN
0.556
3
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.556
3
IntAct:EBI-22419101 CCSB ORF ID
0.556
3
UniProt:Q969G3 SMARCE1
1
SMARCE1 [nucleoplasm]
(R-HSA-389258)
0.556
3
UniProt:Q8NE31 FA13C
0.556
3
UniProt:P48837 NUP57
0.556
3
UniProt:P40325 HUA1
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
IntAct:EBI-11522208 YLR445W
0.556
3
UniProt:P32502
1
GCD7 [cytosol]
(R-SCE-72519)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q96NE9 FRMD6
0.556
3
UniProt:Q8WVP5 TNFAIP8L1
1
TNFAIP8L1 [cytosol]
(R-HSA-8874482)
0.556
3
UniProt:Q8IYE0-2 CCDC146
0.556
3
UniProt:Q8WYA6 CTNNBL1
1
CTNNBL1 [nucleoplasm]
(R-HSA-5420895)
0.556
3
UniProt:Q4VCS5-2 AMOT
0.556
3
UniProt:Q8N8X9 MB213
0.556
3
UniProt:Q32MZ4-4 LRRFIP1
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:A2BDD9 A2BDD9
0.556
3
UniProt:P39518
2
ACSL1 [endoplasmic reticulum membrane]
(R-SCE-201038)
ACSL6 [endoplasmic reticulum membrane]
(R-SCE-548687)
0.556
3
UniProt:O95954 FTCD
1
FTCD [cytosol]
(R-HSA-70907)
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:O43482 OIP5
1
OIP5 [nucleoplasm]
(R-HSA-606286)
0.556
3
UniProt:Q96PC2 IP6K3
1
IP6K3 [cytosol]
(R-HSA-1604594)
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:Q6PIF2 SYCE2
1
SYCE2 [nucleoplasm]
(R-HSA-912451)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q5TB80 CEP162
1
CEP162 [cytosol]
(R-HSA-5626646)
0.528
3
UniProt:O15078 CEP290
3
CEP290 [extracellular region]
(R-HSA-6806291)
CEP290 [specific granule lumen]
(R-HSA-6799524)
CEP290 [cytosol]
(R-HSA-380275)
0.528
3
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:Q9H190 SDCB2
0.488
2
UniProt:Q92731 ESR2
5
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.462
2
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