Reactome | MED4 [nucleoplasm]

MED4 [nucleoplasm]

Stable Identifier

R-HSA-350263

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

MED4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NPJ6 MED4

Gene Names

MED4, ARC36, DRIP36, VDRIP, HSPC126

Chain

initiator methionine:1, chain:2-270

Reference Genes

BioGPS Gene:29079 MED4

COSMIC (genes):MED4 MED4

CTD Gene:29079 MED4

dbSNP Gene:29079 MED4

ENSEMBL:ENSG00000136146.15 MED4

HGNC:17903 MED4

KEGG Gene (Homo sapiens):29079 MED4

Monarch:29079 MED4

NCBI Gene:29079 MED4

OMIM:605718 MED4

UCSC:Q9NPJ6 MED4

Reference Transcript

Other Identifiers

0000840204

11720497_at

11758836_at

16778987

217843_PM_s_at

217843_s_at

222438_PM_at

222438_at

29079

3513401

3513402

3513403

3513404

3513408

3513411

3513413

3513414

3513415

3513416

3513419

3513420

60538_at

78692_at

7971550

A_23_P128543

A_33_P3369766

GE61653

GO:0003712

GO:0003713

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0006351

GO:0006354

GO:0006355

GO:0006357

GO:0006366

GO:0016020

GO:0016592

GO:0030374

GO:0032968

GO:0032991

GO:0042809

GO:0043226

GO:0045893

GO:0046966

GO:0051123

GO:0060261

GO:0065003

GO:0070847

HMNXSV003040949

Hs.181112.0.A3_3p_at

ILMN_1664641

PH_hs_0010716

TC13000653.hg

TC13001486.hg

g7661787_3p_a_at

Participates

as a component of

as an input of

Inferred To

cryba4 [nucleoplasm] (Xenopus tropicalis)

med4 [nucleoplasm] (Danio rerio)

MED4 [nucleoplasm] (Bos taurus)

MED4 [nucleoplasm] (Canis familiaris)

MED4 [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

NP_054885.1, NP_001257558.1

OpenTargets

ENSG00000136146

HPA

ENSG00000136146-MED4

GeneCards

Q9NPJ6

Ensembl

ENSP00000258648, ENST00000378586, ENSP00000367849, ENST00000258648, ENSG00000136146

PRO

Q9NPJ6

Pharos - Targets

Q9NPJ6

PDB

7NVR, 7ENC, 7ENJ, 7LBM, 7ENA, 7EMF

Interactors (61)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.837	7
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.82	12
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.802	6
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.802	8
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.794	8
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.786	11
UniProt:O95379 TNFAIP8	1	TNFAIP8 [cytosol] (R-HSA-8874463)	0.781	7
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.763	5
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.727	8
UniProt:Q8TD31-3 CCHCR1			0.718	6
UniProt:Q8N6Y0 USBP1			0.718	6
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.718	6
UniProt:Q99909 SSX3			0.718	6
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.671	4
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.671	5
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.669	3
UniProt:Q8N3L3 TXLNB			0.666	4
UniProt:Q8IY31 IFT20	3	IFT20 [cilium] (R-HSA-5617624) IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [ciliary tip] (R-HSA-5625355)	0.666	4
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.666	4
UniProt:O14777 NDC80	1	NDC80 [cytosol] (R-HSA-375314)	0.659	4
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.659	4
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.643	3
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.643	3
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.598	4
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.569	6
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.569	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.569	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:P48232 SNAPN			0.556	3
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.556	3
IntAct:EBI-22419101 CCSB ORF ID			0.556	3
UniProt:Q969G3 SMARCE1	1	SMARCE1 [nucleoplasm] (R-HSA-389258)	0.556	3
UniProt:Q8NE31 FA13C			0.556	3
UniProt:P48837 NUP57			0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
IntAct:EBI-11522208 YLR445W			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:O14964 HGS	2	HGS [cytosol] (R-HSA-182954) HGS [phagocytic vesicle lumen] (R-HSA-9635660)	0.556	3
UniProt:Q96NE9 FRMD6			0.556	3
UniProt:Q8WVP5 TNFAIP8L1	1	TNFAIP8L1 [cytosol] (R-HSA-8874482)	0.556	3
UniProt:Q8IYE0-2 CCDC146			0.556	3
UniProt:Q8WYA6 CTNNBL1	1	CTNNBL1 [nucleoplasm] (R-HSA-5420895)	0.556	3
UniProt:Q4VCS5-2 AMOT			0.556	3
UniProt:Q8N8X9 MB213			0.556	3
UniProt:Q32MZ4-4 LRRFIP1			0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:P39518	2	ACSL1 [endoplasmic reticulum membrane] (R-SCE-201038) ACSL6 [endoplasmic reticulum membrane] (R-SCE-548687)	0.556	3
UniProt:O95954 FTCD	1	FTCD [cytosol] (R-HSA-70907)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.556	3
UniProt:Q96PC2 IP6K3	1	IP6K3 [cytosol] (R-HSA-1604594)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q6PIF2 SYCE2	1	SYCE2 [nucleoplasm] (R-HSA-912451)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q5TB80 CEP162	1	CEP162 [cytosol] (R-HSA-5626646)	0.528	3
UniProt:O15078 CEP290	3	CEP290 [extracellular region] (R-HSA-6806291) CEP290 [specific granule lumen] (R-HSA-6799524) CEP290 [cytosol] (R-HSA-380275)	0.528	3
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q9H190 SDCB2			0.488	2
UniProt:Q92731 ESR2	5	Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.462	2

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