Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PTBP1 [nucleoplasm]
Stable Identifier
R-HSA-71923
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP I, PTB_HUMAN, Polypyrimidine tract-binding protein 1, PTB, Heterogeneous nuclear ribonucleoprotein I, 57 kDa RNA-binding protein PPTB-1
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
FGFR2 alternative splicing (Homo sapiens)
FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
PTBP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26599 PTBP1
Gene Names
PTBP1, PTB
Chain
chain:1-557
Reference Genes
BioGPS Gene:5725 PTBP1
COSMIC (genes):PTBP1 PTBP1
CTD Gene:5725 PTBP1
dbSNP Gene:5725 PTBP1
ENSEMBL:ENSG00000011304 PTBP1
ENSEMBL_homo_sapiens_GENE:ENSG00000011304.22 PTBP1
HGNC:9583 PTBP1
KEGG Gene (Homo sapiens):5725 PTBP1
Monarch:5725 PTBP1
NCBI Gene:5725 PTBP1
OMIM:600693 PTBP1
UCSC:P26599 PTBP1
Reference Transcript
RefSeq:NM_031990.3 PTBP1
RefSeq:NM_002819.4 PTBP1
RefSeq:NM_031991.3 PTBP1
Other Identifiers
11742456_a_at
11742457_s_at
11742677_x_at
11742678_s_at
16856257
16856273
202189_PM_x_at
202189_x_at
211270_PM_x_at
211270_x_at
211271_PM_x_at
211271_x_at
212015_PM_x_at
212015_x_at
212016_3p_s_at
212016_PM_s_at
212016_s_at
216306_PM_x_at
216306_x_at
3815167
3815169
3815170
3815171
3815172
3815174
3815176
3815178
3815179
3815181
3815183
3815188
3815192
3815193
3815194
3815195
3815196
3815197
3815198
3815199
3815200
3815201
3815202
3815203
40593_at
5725
8024019
A_14_P138892
A_24_P14367
GE59935
GE87923
GO:0000381
GO:0003676
GO:0003677
GO:0003723
GO:0003729
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0006351
GO:0006355
GO:0006397
GO:0008187
GO:0008380
GO:0010467
GO:0016020
GO:0016071
GO:0022008
GO:0023052
GO:0030154
GO:0033119
GO:0035307
GO:0036002
GO:0036211
GO:0043226
GO:0043484
GO:0045595
GO:0045665
GO:0045944
GO:0048025
GO:0048856
GO:0051148
GO:0070062
GO:0070886
GO:0075522
HMNXSV003020025
HMNXSV003036042
Hs.172550.3.S1_3p_a_at
Hs.172550.3.S1_3p_x_at
Hs.172550.6.A1_3p_a_at
ILMN_1655154
ILMN_2333319
PH_hs_0010319
TC19000015.hg
TC19000016.hg
g13325139_3p_a_at
g4506242_3p_x_at
p8489
Participates
as a component of
hnRNP proteins [nucleoplasm] (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
as a member of
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
as an input of
PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)
Inferred To
PTBP1 [nucleoplasm]
(Bos taurus)
PTBP1 [nucleoplasm]
(Canis familiaris)
PTBP1 [nucleoplasm]
(Dictyostelium discoideum)
PTBP1 [nucleoplasm]
(Gallus gallus)
PTBP1 [nucleoplasm]
(Plasmodium falciparum)
PTBP1 [nucleoplasm]
(Sus scrofa)
ptb-1 [nucleoplasm]
(Caenorhabditis elegans)
ptbp1 [nucleoplasm]
(Xenopus tropicalis)
Ptbp1 [nucleoplasm]
(Mus musculus)
Ptbp1 [nucleoplasm]
(Rattus norvegicus)
ptbp1a [nucleoplasm]
(Danio rerio)
heph [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002810.1
,
NP_114368.1
,
NP_114367.1
OpenTargets
ENSG00000011304
HPA
ENSG00000011304-PTBP1
GeneCards
P26599
Ensembl
ENSP00000408096
,
ENSP00000349428
,
ENST00000349038
,
ENSP00000014112
,
ENST00000356948
,
ENSG00000011304
,
ENST00000394601
PRO
P26599
Pharos - Targets
P26599
PDB
1SJQ
,
2AD9
,
1QM9
,
8BWF
,
2ADC
,
2ADB
,
1SJR
,
3ZZZ
,
2EVZ
,
3ZZY
,
2N3O
,
8BGF
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P09012 SNRPA
1
SNRPA [nucleoplasm]
(R-HSA-71915)
0.8
7
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.749
13
UniProt:P23246 SFPQ
3
SFPQ [cytosol]
(R-HSA-9635505)
p-Y-SFPQ [nucleoplasm]
(R-HSA-8849461)
SFPQ [nucleoplasm]
(R-HSA-3900138)
0.702
4
UniProt:P98175 RBM10
1
RBM10 [nucleoplasm]
(R-HSA-9770262)
0.666
4
UniProt:Q7ZYE9 Q7ZYE9
0.639
4
UniProt:Q96PU8 QKI
2
QKI(1-504)-RAF1(278-648) fusion [cytosol]
(R-HSA-6802466)
QKI(1-504)-p-RAF1(278- 648) fusion [cytosol]
(R-HSA-6802546)
0.635
3
UniProt:P26599 PTBP1
1
PTBP1 [nucleoplasm]
(R-HSA-71923)
0.553
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.527
2
UniProt:Q9UBW7 ZMYM2
6
ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1839016)
ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604544)
ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol]
(R-HSA-9703309)
ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol]
(R-HSA-9703319)
ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol]
(R-HSA-9703310)
ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol]
(R-HSA-9703311)
0.524
2
UniProt:Q15365 PCBP1
1
PCBP1 [nucleoplasm]
(R-HSA-71919)
0.508
2
UniProt:Q8IUH3 RBM45
0.462
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text