Reactome | p-T286-CCND1 [nucleoplasm]

p-T286-CCND1 [nucleoplasm]

Stable Identifier

R-HSA-75811

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

phospho(T286)-Cyclin D1, G1/S-specific cyclin D1, PRAD1 oncogene, BCL-1 oncogene

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P24385 CCND1

Gene Names

CCND1, BCL1, PRAD1

Chain

chain:1-295

Reference Genes

BioGPS Gene:595 CCND1

COSMIC (genes):CCND1 CCND1

CTD Gene:595 CCND1

dbSNP Gene:595 CCND1

ENSEMBL:ENSG00000110092 CCND1

HGNC:1582 CCND1

KEGG:hsa:595 CCND1

Monarch:595 CCND1

NCBI Gene:595 CCND1

OMIM:168461 CCND1

UCSC:P24385 CCND1

Reference Transcript

RefSeq:NM_053056.2 CCND1

Other Identifiers

11721255_at

11721256_a_at

11721257_at

11751330_a_at

16728261

2017_s_at

2020_at

208711_PM_s_at

208711_s_at

208712_3p_at

208712_PM_at

208712_at

3338194

3338195

3338196

3338204

3338205

3338206

3338207

3338208

3338209

3338210

3338211

3338212

3338213

3338214

3338215

3338216

38418_at

595

7942123

A_14_P117958

A_23_P202837

A_24_P124550

A_24_P193011

GO:0000082

GO:0000122

GO:0000307

GO:0000320

GO:0001934

GO:0003714

GO:0003824

GO:0004672

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005923

GO:0006355

GO:0006974

GO:0007595

GO:0008283

GO:0009410

GO:0010971

GO:0016020

GO:0016055

GO:0016301

GO:0016538

GO:0016740

GO:0017053

GO:0019899

GO:0019901

GO:0030154

GO:0030182

GO:0030857

GO:0030968

GO:0031571

GO:0031965

GO:0033598

GO:0033601

GO:0042826

GO:0043226

GO:0043524

GO:0044321

GO:0044772

GO:0045444

GO:0045737

GO:0048856

GO:0051301

GO:0051726

GO:0060090

GO:0060749

GO:0061575

GO:0070064

GO:0070141

GO:0097128

GO:0097131

GO:0097421

GO:0098772

GO:0140096

GO:0140110

GO:1900087

GO:2000045

HMNXSV003049250

ILMN_1688480

PH_hs_0024184

TC11000718.hg

X59798_at

g12652656_3p_s_at

g179364_3p_at

g179364_3p_x_at

Participates

as a component of

phospho(T286)-Cyclin D1:Cdk4 [nucleoplasm] (Homo sapiens)

as an input of

Relocalization of nuclearly localized Cyclin D1 to the cytoplasm (Homo sapiens)

Other forms of this molecule

CCND1 [nucleoplasm]

CCND1 [cytosol]

p-T286-CCND1 [cytosol]

Inferred To

phospho-CCND1 [nucleoplasm] (Bos taurus)

phospho-CCND1 [nucleoplasm] (Canis familiaris)

phospho-CCND1 [nucleoplasm] (Gallus gallus)

phospho-CCND1 [nucleoplasm] (Sus scrofa)

phospho-ccnd1 [nucleoplasm] (Danio rerio)

phospho-ccnd1 [nucleoplasm] (Xenopus tropicalis)

phospho-CycD [nucleoplasm] (Drosophila melanogaster)

phospho-crs1 [nucleoplasm] (Schizosaccharomyces pombe)

phospho-Ccnd1 [nucleoplasm] (Mus musculus)

phospho-Ccnd1 [nucleoplasm] (Rattus norvegicus)

phospho-cyd-1 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-threonine at 286

Coordinate

286

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_444284.1

OpenTargets

ENSG00000110092

ENSEMBL

ENST00000227507, ENSP00000227507

HPA

ENSG00000110092-CCND1

PRO

P24385

Pharos - Targets

P24385

Orphanet

CCND1

GlyGen

P24385

HMDB Protein

HMDBP02156

PDB

2W99, 5VZU, 6P8E, 6P8G, 6P8F, 6P8H, 2W9Z, 2W9F, 2W96

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11802 CDK4	3	p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843) CDK4 [cytosol] (R-HSA-68330)	0.985	45
UniProt:P38936 CDKN1A	5	p-S130-CDKN1A [nucleoplasm] (R-HSA-187857) CDKN1A [nucleoplasm] (R-HSA-182585) CDKN1A [cytosol] (R-HSA-182512) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) p-T145-CDKN1A [cytosol] (R-HSA-198614)	0.962	25
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.905	12
UniProt:P24941 CDK2	5	p-T160-CDK2 [nucleoplasm] (R-HSA-187967) CDK2 [nucleoplasm] (R-HSA-68365) CDK2 [cytosol] (R-HSA-157440) p-CDK2 [nucleoplasm] (R-HSA-68370) p-Y15-CDK2 [nucleoplasm] (R-HSA-187905)	0.845	8
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.839	7
IntAct:EBI-4399559 UBIQ			0.743	4
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.73	5
UniProt:P06493 CDK1	11	p-T161-CDK1 [nucleoplasm] (R-HSA-170066) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) CDK1 [cytosol] (R-HSA-170075) CDK1 [nucleoplasm] (R-HSA-68889) p-T14-CDK1 [cytosol] (R-HSA-170064) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-Y4-CDK1 [cytosol] (R-HSA-9836187) CDK1 [endoplasmic reticulum membrane] (R-HSA-264424)	0.643	3
UniProt:Q00535 CDK5	4	p-Y15-CDK5 [cytosol] (R-HSA-399809) CDK5 [cytosol] (R-HSA-180064) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [nucleoplasm] (R-HSA-8863586)	0.643	4
UniProt:Q96PU4 UHRF2	1	UHRF2 [nucleoplasm] (R-HSA-976050)	0.602	4
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.59	2
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.576	3
UniProt:Q5XUX0 FBXO31	1	FBXO31 [cytosol] (R-HSA-8850911)	0.576	4
UniProt:Q96TE0 Q96TE0			0.556	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.544	3
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.544	4
UniProt:P49918 CDKN1C	3	p-Y91-CDKN1C [cytosol] (R-HSA-8942606) CDKN1C [cytosol] (R-HSA-8941913) CDKN1C [nucleoplasm] (R-HSA-8948130)	0.527	3
UniProt:Q07283 TCHH	2	TCHH [cornified envelope] (R-HSA-8934848) TCHH [cytosol] (R-HSA-6810842)	0.527	2
UniProt:P42773 CDKN2C	1	CDKN2C [cytosol] (R-HSA-182572)	0.527	3
UniProt:Q16656 NRF1	1	NRF1 [nucleoplasm] (R-HSA-1592205)	0.508	2
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.499	3
UniProt:P42771 CDKN2A	20	p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294)	0.491	2
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.463	3
UniProt:Q13761 RUNX3	7	PolyUb-RUNX3 [nucleoplasm] (R-HSA-8952417) p-Y-RUNX3 [cytosol] (R-HSA-8937805) PolyUb-K94,K148-RUNX3 [nucleoplasm] (R-HSA-8952387) PolyUb-K94,K148-RUNX3 [cytosol] (R-HSA-8952400) Ac-K94,K171-RUNX3 [nucleoplasm] (R-HSA-8951965) RUNX3 [cytosol] (R-HSA-8937797) RUNX3 [nucleoplasm] (R-HSA-8865393)	0.462	8

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