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EXOC5 [cytosol]
Stable Identifier
R-HSA-5623383
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SEC10, SEC10L1
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
VxPx cargo-targeting to cilium (Homo sapiens)
The exocyst complex binds to RAB3IP in the ciliary targeting complex (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC5 [cytosol] (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC5 [cytosol] (Homo sapiens)
VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Homo sapiens)
exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Homo sapiens)
exocyst complex [cytosol] (Homo sapiens)
EXOC5 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00471 EXOC5
Gene Names
EXOC5, SEC10, SEC10L1
Chain
initiator methionine:1, chain:2-708
Reference Genes
BioGPS Gene:10640 EXOC5
COSMIC (genes):EXOC5 EXOC5
CTD Gene:10640 EXOC5
dbSNP Gene:10640 EXOC5
ENSEMBL:ENSG00000070367 EXOC5
HGNC:10696 EXOC5
KEGG Gene (Homo sapiens):10640 EXOC5
Monarch:10640 EXOC5
NCBI Gene:10640 EXOC5
OMIM:604469 EXOC5
UCSC:O00471 EXOC5
Reference Transcript
RefSeq:NM_006544.3 EXOC5
Other Identifiers
0000940025
10640
11719456_at
11719457_s_at
11719458_at
11719459_at
11749681_a_at
11749682_s_at
11757786_s_at
16793353
218748_s_at
222726_3p_s_at
222726_s_at
225084_at
228418_at
2729215
2729216
2729217
2729222
3566301
3566303
3566305
3566306
3566307
3566308
3566310
3566311
3566312
3566315
3566316
3566318
3566320
3566321
3566324
3566328
3566329
3566331
3566333
3566334
3566342
3566343
3566344
3566345
3566351
3566352
45744_at
57159_at
7979367
8095333
88639_at
A_23_P14464
A_24_P224219
A_24_P256830
A_32_P172755
GE78968
GO:0000145
GO:0001736
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006810
GO:0006887
GO:0006892
GO:0006893
GO:0008150
GO:0008219
GO:0015031
GO:0016192
GO:0017160
GO:0019899
GO:0022607
GO:0030496
GO:0032991
GO:0047485
GO:0048278
GO:0048856
GO:0072659
GO:1904019
GO:1905515
Hs.279947.0.S2_3p_s_at
Hs.29494.1.S1_3p_at
Hs.29494.2.S1_3p_at
Hs.29494.2.S1_3p_x_at
ILMN_1788625
PH_hs_0029885
TC14001170.hg
U85946_at
g5730036_3p_a_at
Participant Of
hasComponent
exocyst complex [cytosol]
Other forms of this molecule
EXOC5 [cytosol]
Inferred To
EXOC5 [cytosol] (Bos taurus)
EXOC5 [cytosol] (Canis familiaris)
EXOC5 [cytosol] (Gallus gallus)
EXOC5 [cytosol] (Sus scrofa)
Sec10 [cytosol] (Drosophila melanogaster)
Exoc5 [cytosol] (Mus musculus)
Exoc5 [cytosol] (Rattus norvegicus)
sec-10 [cytosol] (Caenorhabditis elegans)
exoc5 [cytosol] (Danio rerio)
exoc5 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_006535.1
OpenTargets
ENSG00000070367
HPA
ENSG00000070367-EXOC5
GeneCards
O00471
Ensembl
ENSP00000484855
,
ENSG00000070367
,
ENST00000621441
PRO
O00471
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8TAG9 EXOC6
2
EXOC6 [plasma membrane]
(R-HSA-265041)
EXOC6 [cytosol]
(R-HSA-5623384)
0.793
7
UniProt:Q9Y2D4 EXC6B
0.731
7
UniProt:Q13882 PTK6
5
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
PTK6 [cytosol]
(R-HSA-8848000)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.718
6
UniProt:P20338 RAB4A
5
GGC-RAB4A [cytosol]
(R-HSA-8874045)
GGC-RAB4A [cytoplasmic vesicle membrane]
(R-HSA-1458526)
RAB4A [cytosol]
(R-HSA-8873709)
RAB4A [early endosome membrane]
(R-HSA-8871356)
GGC-RAB4A [recycling endosome membrane]
(R-HSA-8875666)
0.718
6
UniProt:P00973-2 OAS1
0.718
6
UniProt:Q05D60 DEUP1
0.718
11
UniProt:P61106 RAB14
7
GGC-RAB14 [recycling endosome membrane]
(R-HSA-8876593)
GGC-RAB14 [cytoplasmic vesicle membrane]
(R-HSA-1445086)
GGC-RAB14 [cytosol]
(R-HSA-8873763)
RAB14 [cytosol]
(R-HSA-8873701)
RAB14 [early endosome membrane]
(R-HSA-8871372)
RAB14 [plasma membrane]
(R-HSA-6806438)
RAB14 [tertiary granule membrane]
(R-HSA-6800407)
0.718
6
UniProt:P43360 MAGA6
0.718
6
UniProt:P61018 RAB4B
5
RAB4B [cytosol]
(R-HSA-8873680)
GGC-RAB4B [cytosol]
(R-HSA-8874049)
GGC-RAB4B [recycling endosome membrane]
(R-HSA-8875675)
RAB4B [plasma membrane]
(R-HSA-6804989)
RAB4B [secretory granule membrane]
(R-HSA-6804976)
0.718
6
UniProt:O14787 TNPO2
0.666
4
UniProt:Q8N3L3 TXLNB
0.666
4
UniProt:O60645 EXOC3
2
EXOC3 [secretory granule membrane]
(R-HSA-2872286)
EXOC3 [cytosol]
(R-HSA-5623379)
0.638
3
UniProt:Q8IYI6 EXOC8
2
EXOC8 [cytosol]
(R-HSA-5623388)
EXOC8 [plasma membrane]
(R-HSA-264948)
0.638
4
UniProt:Q6FHV6 Q6FHV6
0.556
3
UniProt:Q5PSV4 BRM1L
0.556
3
UniProt:A0A0S2Z528 A0A0S2Z528
0.556
3
UniProt:Q8N4P3 MESH1
0.556
3
UniProt:Q6PF05-3 TTC23L
0.556
3
UniProt:Q9BQD3 KXDL1
0.556
3
UniProt:Q96E40 SACA9
0.556
3
UniProt:Q9ULZ3 PYCARD
4
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.556
5
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q3B7T1-5 EDRF1
0.556
3
UniProt:P83876 TXNL4A
1
TXNL4A [nucleoplasm]
(R-HSA-71875)
0.556
3
UniProt:A0A0S2Z4Q4 A0A0S2Z4Q4
0.556
3
UniProt:A0AVN2 A0AVN2
0.556
3
IntAct:EBI-16430217 CCSB ISOFORM ID
0.556
3
UniProt:Q68D86 C102B
0.556
3
UniProt:Q96FV9 THOC1
1
THOC1 [nucleoplasm]
(R-HSA-8849130)
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:Q99728 BARD1
2
BARD1 [nucleoplasm]
(R-HSA-5659775)
p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-5659846)
0.556
3
UniProt:P00973 OAS1
1
OAS1 [cytosol]
(R-HSA-947486)
0.556
3
UniProt:Q9NWB7 IFT57
2
IFT57 [cilium]
(R-HSA-5610389)
IFT57 [ciliary tip]
(R-HSA-5625363)
0.556
3
UniProt:P02671-2 FGA
0.556
3
UniProt:Q96NE9 FRMD6
0.556
3
UniProt:P43357 MAGA3
0.556
3
UniProt:O14964 HGS
2
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
HGS [cytosol]
(R-HSA-182954)
0.556
3
UniProt:P53674 CRBB1
0.556
3
UniProt:Q9UPT5 EXOC7
2
EXOC7 [cytosol]
(R-HSA-5623386)
EXOC7 [plasma membrane]
(R-HSA-2872288)
0.508
3
UniProt:Q15051 IQCB1
1
IQCB1 [cytosol]
(R-HSA-5626648)
0.508
2
UniProt:P61006 RAB8A
6
RAB8A [cytosol]
(R-HSA-5623399)
RAB8A [Golgi membrane]
(R-HSA-2562535)
GGC-RAB8A [cytosol]
(R-HSA-8874063)
GGC-RAB8A [trans-Golgi network membrane]
(R-HSA-8876082)
RAB8A [recycling endosome membrane]
(R-HSA-8854145)
GGC-RAB8A [cytoplasmic vesicle membrane]
(R-HSA-1445093)
0.508
2
UniProt:O15014 ZN609
0.508
2
UniProt:Q9NV70 EXOC1
2
EXOC1 [cytosol]
(R-HSA-5623375)
EXOC1 [plasma membrane]
(R-HSA-2872284)
0.508
3
UniProt:Q13586 STIM1
1
STIM1 [endoplasmic reticulum membrane]
(R-HSA-434675)
0.508
2
UniProt:P46459 NSF
1
NSF [cytosol]
(R-HSA-264471)
0.508
2
UniProt:Q96A65 EXOC4
2
EXOC4 [plasma membrane]
(R-HSA-264989)
EXOC4 [cytosol]
(R-HSA-5623381)
0.508
3
UniProt:Q96KP1 EXOC2
2
EXOC2 [plasma membrane]
(R-HSA-264887)
EXOC2 [cytosol]
(R-HSA-5623376)
0.508
2
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