Reactome | AP2B1 [endolysosome membrane]

AP2B1 [endolysosome membrane]

Stable Identifier

R-HSA-6784827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome membrane

Synonyms

AP-2 beta 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P63010 AP2B1

Gene Names

AP2B1, ADTB2, CLAPB1

Chain

initiator methionine:1, chain:2-937

Reference Genes

BioGPS Gene:163 AP2B1

COSMIC (genes):AP2B1 AP2B1

CTD Gene:163 AP2B1

dbSNP Gene:163 AP2B1

ENSEMBL:ENSG00000006125.18 AP2B1

HGNC:563 AP2B1

KEGG Gene (Homo sapiens):163 AP2B1

Monarch:163 AP2B1

NCBI Gene:163 AP2B1

OMIM:601025 AP2B1

UCSC:P63010 AP2B1

Reference Transcript

Other Identifiers

0003120632

11716261_a_at

11716262_a_at

163

16833345

200612_PM_s_at

200612_s_at

200615_PM_s_at

200615_s_at

36161_at

3718683

3718684

3718686

3718696

3718700

3718703

3718706

3718707

3718708

3718709

3718710

3718712

3718713

3718714

3718715

3718717

3718718

3718721

3718722

3718723

3718724

3718725

3718730

3718732

3718735

3718739

3718740

3718741

4014722

4014723

4014724

4014729

4014731

4014733

4014735

4014738

8006542

A_23_P55149

A_24_P253827

GE57939

GO:0001822

GO:0003279

GO:0003281

GO:0003674

GO:0005048

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006886

GO:0006897

GO:0007507

GO:0008150

GO:0009898

GO:0015031

GO:0016020

GO:0016192

GO:0030117

GO:0030122

GO:0030131

GO:0030276

GO:0030666

GO:0030669

GO:0030674

GO:0031090

GO:0031410

GO:0032991

GO:0035615

GO:0035904

GO:0036020

GO:0043226

GO:0045334

GO:0048856

GO:0060976

GO:0072583

GO:0098794

GO:0098884

GO:0098978

GO:0099590

HMNXSV003043367

Hs.74626.0.A1_3p_s_at

ILMN_1681998

ILMN_2331735

M34175_at

PH_hs_0024131

TC17000399.hg

g4557468_3p_a_at

Participates

as a component of

Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)

Other forms of this molecule

AP2B1 [plasma membrane]

AP2B1 [clathrin-coated endocytic vesicle membrane]

AP2B1 [cytosol]

Inferred To

AP2B1 [endolysosome membrane] (Bos taurus)

AP2B1 [endolysosome membrane] (Canis familiaris)

AP2B1 [endolysosome membrane] (Danio rerio)

AP2B1 [endolysosome membrane] (Gallus gallus)

AP2B1 [endolysosome membrane] (Sus scrofa)

APL1 [endolysosome membrane] (Saccharomyces cerevisiae)

ap1b1 [endolysosome membrane] (Dictyostelium discoideum)

apb-1 [endolysosome membrane] (Caenorhabditis elegans)

apl2 [endolysosome membrane] (Schizosaccharomyces pombe)

apl1 [endolysosome membrane] (Schizosaccharomyces pombe)

AP-1-2beta [endolysosome membrane] (Drosophila melanogaster)

APL2 [endolysosome membrane] (Saccharomyces cerevisiae)

ap2b1 [endolysosome membrane] (Xenopus tropicalis)

Ap2b1 [endolysosome membrane] (Mus musculus)

Ap2b1 [endolysosome membrane] (Rattus norvegicus)

Homologues of AP2B1 [endolysosome membrane] (Saccharomyces cerevisiae)

Homologues of AP2B1 [endolysosome membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_016879775.1, XP_016879773.1, NP_001273.1, XP_011522757.1, NP_001025177.1, XP_005257995.1, XP_005257994.1

OpenTargets

ENSG00000006125

GeneCards

P63010

HPA

ENSG00000006125-AP2B1

Ensembl

ENST00000618940, ENSP00000483185, ENST00000621914, ENSP00000482315, ENST00000610402, ENSP00000482835, ENSG00000006125

PRO

P63010

Pharos - Targets

P63010

PDB

2IV9, 2G30, 6QH5, 5M5R, 2JKT, 6YAH, 4UQI, 6YAI, 7OM8, 6YAE, 1E42, 6QH6, 2IV8, 2VGL, 2JKR, 2XA7, 6URI, 6YAF, 6QH7

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5SW96 LDLRAP1	2	LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869097) LDLRAP1 [plasma membrane] (R-HSA-171143)	0.773	5
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.678	3
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374) SLC25A6 [mitochondrial inner membrane] (R-HSA-49745)	0.666	4
UniProt:Q15811 ITSN1	1	ITSN1 [cytosol] (R-HSA-3006481)	0.592	3
UniProt:P42566 EPS15	2	p-Y850 EPS15 [cytosol] (R-HSA-8867028) EPS15 [cytosol] (R-HSA-182920)	0.59	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.569	5
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.556	3
UniProt:Q99757 TXN2	2	TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.556	3
UniProt:P29353 SHC1	5	SHC1 [cytosol] (R-HSA-74680) p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4

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