Reactome | AP2B1 [endolysosome membrane]

AP2B1 [endolysosome membrane]

Stable Identifier

R-HSA-6784827

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endolysosome membrane

Synonyms

AP-2 beta 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P63010 AP2B1

Gene Names

AP2B1, ADTB2, CLAPB1

Chain

initiator methionine:1, chain:2-937

Reference Genes

BioGPS Gene:163 AP2B1

COSMIC (genes):AP2B1 AP2B1

CTD Gene:163 AP2B1

dbSNP Gene:163 AP2B1

ENSEMBL:ENSG00000006125 AP2B1

HGNC:563 AP2B1

KEGG Gene (Homo sapiens):163 AP2B1

Monarch:163 AP2B1

NCBI Gene:163 AP2B1

OMIM:601025 AP2B1

UCSC:P63010 AP2B1

Reference Transcript

Other Identifiers

0003120632

11716261_a_at

11716262_a_at

163

16833345

200612_s_at

200615_s_at

36161_at

3718683

3718684

3718686

3718696

3718700

3718703

3718706

3718707

3718708

3718709

3718710

3718712

3718713

3718714

3718715

3718717

3718718

3718721

3718722

3718723

3718724

3718725

3718730

3718732

3718735

3718739

3718740

3718741

4014722

4014723

4014724

4014729

4014731

4014733

4014735

4014738

8006542

A_23_P55149

A_24_P253827

GE57939

GO:0001822

GO:0002376

GO:0003279

GO:0003281

GO:0003674

GO:0005048

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005768

GO:0005773

GO:0005829

GO:0005886

GO:0005905

GO:0006810

GO:0006886

GO:0006897

GO:0007165

GO:0007267

GO:0007507

GO:0008150

GO:0008219

GO:0009056

GO:0015031

GO:0016020

GO:0016192

GO:0019886

GO:0022607

GO:0030117

GO:0030118

GO:0030122

GO:0030131

GO:0030276

GO:0030666

GO:0030669

GO:0030674

GO:0031410

GO:0032802

GO:0032991

GO:0034383

GO:0035615

GO:0035904

GO:0036020

GO:0043226

GO:0044403

GO:0044877

GO:0045334

GO:0045807

GO:0048013

GO:0048268

GO:0048856

GO:0050690

GO:0060071

GO:0060976

GO:0061024

GO:0065003

GO:0072583

GO:0098794

GO:0098884

GO:0098978

GO:0099590

GO:1901215

GO:1905477

HMNXSV003043367

Hs.74626.0.A1_3p_s_at

ILMN_1681998

ILMN_2331735

M34175_at

PH_hs_0024131

TC17000399.hg

g4557468_3p_a_at

Participates

as a component of

Adaptor protein 2 complex [endolysosome membrane] (Homo sapiens)

Other forms of this molecule

AP2B1 [plasma membrane]

AP2B1 [clathrin-coated endocytic vesicle membrane]

AP2B1 [cytosol]

Inferred To

AP2B1 [endolysosome membrane] (Canis familiaris)

AP2B1 [endolysosome membrane] (Gallus gallus)

AP2B1 [endolysosome membrane] (Sus scrofa)

APL1 [endolysosome membrane] (Saccharomyces cerevisiae)

ap1b1 [endolysosome membrane] (Dictyostelium discoideum)

apb-1 [endolysosome membrane] (Caenorhabditis elegans)

apl2 [endolysosome membrane] (Schizosaccharomyces pombe)

apl1 [endolysosome membrane] (Schizosaccharomyces pombe)

AP-1-2beta [endolysosome membrane] (Drosophila melanogaster)

APL2 [endolysosome membrane] (Saccharomyces cerevisiae)

ap2b1 [endolysosome membrane] (Danio rerio)

Ap2b1 [endolysosome membrane] (Mus musculus)

Ap2b1 [endolysosome membrane] (Rattus norvegicus)

Homologues of AP2B1 [endolysosome membrane] (Saccharomyces cerevisiae)

Homologues of AP2B1 [endolysosome membrane] (Schizosaccharomyces pombe)

Cross References

RefSeq

XP_005257994.1, NP_001025177.1, XP_011522757.1, NP_001273.1, XP_016879773.1, XP_016879775.1, XP_005257995.1

OpenTargets

ENSG00000006125

GeneCards

P63010

HPA

ENSG00000006125-AP2B1

Ensembl

ENST00000621914, ENSG00000006125, ENST00000610402, ENSP00000482835, ENSP00000482315, ENSP00000483185, ENST00000618940

PRO

P63010

PDB

4UQI, 2JKT, 1E42, 6YAI, 6YAF, 2JKR, 2IV8, 6QH6, 6QH5, 5M5R, 2G30, 6YAE, 6YAH, 6URI, 2VGL, 2IV9, 2XA7, 6QH7

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5SW96 LDLRAP1	2	LDLRAP1 [plasma membrane] (R-HSA-171143) LDLRAP1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869097)	0.681	4
UniProt:Q96CW1 AP2M1	6	AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [endolysosome membrane] (R-HSA-6784828) AP2M1 [lysosomal membrane] (R-HSA-196144) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.678	3
UniProt:P12236 SLC25A6	2	SLC25A6 [mitochondrial inner membrane] (R-HSA-49745) SLC25A6 [mitochondrial intermembrane space] (R-HSA-1955374)	0.666	4
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.556	3
UniProt:Q99757 TXN2	3	HC-TXN2 [mitochondrial matrix] (R-HSA-9035482) TXN2 [mitochondrial matrix] (R-HSA-3323048) 2xHC-TXN2 [mitochondrial matrix] (R-HSA-3323059)	0.556	3
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y-SHC1 [cytosol] (R-HSA-162568) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321)	0.527	3
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2

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