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ACACA [cytosol]
Stable Identifier
R-HSA-1660609
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Acetyl-CoA carboxylase 1, ACACA_HUMAN, ACC1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in biotin (Btn) metabolism (Homo sapiens)
Defective HLCS causes multiple carboxylase deficiency (Homo sapiens)
Defective HLCS does not biotinylate ACACA:Mn2+ (Homo sapiens)
ACACA:2Mn2+ [cytosol] (Homo sapiens)
ACACA [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
ChREBP activates metabolic gene expression (Homo sapiens)
Transcriptional activation of ACACA by ChREBP:MLX (Homo sapiens)
ACACA [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
Activation of gene expression by SREBF (SREBP) (Homo sapiens)
Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)
ACACA [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
HLCS biotinylates ACACA:Mn2+ (Homo sapiens)
ACACA:2Mn2+ [cytosol] (Homo sapiens)
ACACA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13085 ACACA
Gene Names
ACACA, ACAC, ACC1, ACCA
Chain
chain:1-2346
Reference Genes
dbSNP Gene:31 ACACA
ENSEMBL:ENSG00000278540 ACACA
Participates
as an output of
Expression of Acetyl CoA Carboxylase 1 (ACACA, ACC1) (Homo sapiens)
Transcriptional activation of ACACA by ChREBP:MLX (Homo sapiens)
as a component of
ACACA:2Mn2+ [cytosol] (Homo sapiens)
Other forms of this molecule
Btn-ACACA [cytosol]
Inferred To
acaca [cytosol]
(Xenopus tropicalis)
ACC [cytosol]
(Drosophila melanogaster)
ACACA [cytosol]
(Bos taurus)
ACACA [cytosol]
(Canis familiaris)
ACACA [cytosol]
(Dictyostelium discoideum)
ACACA [cytosol]
(Gallus gallus)
ACACA [cytosol]
(Mus musculus)
ACACA [cytosol]
(Plasmodium falciparum)
ACACA [cytosol]
(Rattus norvegicus)
ACACA [cytosol]
(Saccharomyces cerevisiae)
ACACA [cytosol]
(Schizosaccharomyces pombe)
ACACA [cytosol]
(Sus scrofa)
pod-2 [cytosol]
(Caenorhabditis elegans)
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9CQ20
1
Mid1ip1 [cytosol]
(R-MMU-8867328)
0.642
4
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.591
3
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.564
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.564
2
UniProt:Q13085 ACACA
2
ACACA [cytosol]
(R-HSA-1660609)
Btn-ACACA [cytosol]
(R-HSA-2976730)
0.558
2
UniProt:O60218 AKR1B10
1
AKR1B10 [cytosol]
(R-HSA-2855246)
0.556
4
UniProt:Q15418 RPS6KA1
7
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
0.527
2
UniProt:P25098 GRK2
4
GRK2 [plasma membrane]
(R-HSA-50270)
p-S29-ADRBK1 [plasma membrane]
(R-HSA-111969)
ADRBK1 [cilium]
(R-HSA-5632504)
p-S29-ADRBK1 [cytosol]
(R-HSA-9645318)
0.527
2
UniProt:Q9H6Z9 EGLN3
2
EGLN3 [nucleoplasm]
(R-HSA-1234104)
EGLN3 [cytosol]
(R-HSA-1234115)
0.527
2
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.524
2
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