Reactome | GAPDH [cytosol]

GAPDH [cytosol]

Stable Identifier

R-HSA-70428

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

glyceraldehyde-3-phosphate dehydrogenase monomer, glyceraldehyde 3-phosphate dehydrogenase, liver, glyceraldehyde 3-phosphate dehydrogenase, muscle, G3P2_HUMAN, G3P1_HUMAN, Glyceraldehyde 3-phosphate dehydrogenase, liver

Locations in the PathwayBrowser

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General

While there are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, there is only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989). Consistent with this conclusion, the homogeneous enzymes purified from various human tissues had indistinguishable physical and immunochemical properties (Heinz and Freimuller 1982), and studies of human erythrocytes of various ages suggested that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).

External Reference Information

External Reference

UniProt:P04406 GAPDH

Gene Names

GAPDH, GAPD, CDABP0047, OK/SW-cl.12

Chain

initiator methionine:, chain:2-335

Reference Genes

BioGPS Gene:2597 GAPDH

COSMIC (genes):GAPDH GAPDH

CTD Gene:2597 GAPDH

dbSNP Gene:2597 GAPDH

ENSEMBL:ENSG00000111640 GAPDH

HGNC:4141 GAPDH

KEGG:hsa:2597 GAPDH

Monarch:2597 GAPDH

NCBI Gene:2597 GAPDH

OMIM:138400 GAPDH

UCSC:P04406 GAPDH

Reference Transcript

Other Identifiers

11754912_x_at

16747338

212581_PM_x_at

212581_x_at

213453_PM_x_at

213453_x_at

217398_3p_x_at

217398_PM_x_at

217398_x_at

2347474

2379956

2597

2962139

3290165

3402627

3402628

3402629

3402630

3402631

3402632

3402633

3402634

3402635

3402636

3402637

3402638

3402639

3402640

3402641

3402642

3402643

3402644

3402645

3402646

3402647

3402648

3402649

3402650

3402651

3402652

3402653

3419406

3419414

35905_s_at

3992397

4005331

4005332

4005336

4006736

7953385

AFFX-HUMGAPDH/M33197_3_at

AFFX-HUMGAPDH/M33197_5_at

AFFX-HUMGAPDH/M33197_M_at

A_14_P116558

GE80009

GO:0000166

GO:0000226

GO:0001819

GO:0002376

GO:0003824

GO:0004365

GO:0005515

GO:0005634

GO:0005737

GO:0005811

GO:0005829

GO:0005856

GO:0005886

GO:0005975

GO:0006006

GO:0006091

GO:0006096

GO:0006417

GO:0006915

GO:0007010

GO:0008017

GO:0008092

GO:0010951

GO:0012501

GO:0015630

GO:0016020

GO:0016241

GO:0016491

GO:0016620

GO:0016740

GO:0017148

GO:0019828

GO:0031640

GO:0031965

GO:0031982

GO:0032481

GO:0035605

GO:0035606

GO:0042802

GO:0043123

GO:0043226

GO:0043231

GO:0045087

GO:0048471

GO:0050661

GO:0050821

GO:0050832

GO:0051287

GO:0051402

GO:0051873

GO:0055086

GO:0061844

GO:0070062

GO:0071346

GO:0097452

GO:0097718

GO:0098542

GO:0098772

GO:0140096

GO:1901135

GO:1990904

HMNXSV003017455

Hs.169476.4.A1_3p_s_at

Hs.169476.5.A1_3p_s_at

ILMN_1343295

ILMN_1802252

ILMN_2038778

PH_hs_0037816

TC12000084.hg

TC12002203.hg

TC16001826.hg

X01677_f_at

Participates

as a component of

glyceraldehyde-3-phosphate dehydrogenase tetramer [cytosol] (Homo sapiens)

Inferred To

GAPDH [cytosol] (Bos taurus)

GAPDH [cytosol] (Caenorhabditis elegans)

GAPDH [cytosol] (Canis familiaris)

GAPDH [cytosol] (Danio rerio)

GAPDH [cytosol] (Dictyostelium discoideum)

GAPDH [cytosol] (Drosophila melanogaster)

GAPDH [cytosol] (Gallus gallus)

GAPDH [cytosol] (Mus musculus)

GAPDH [cytosol] (Plasmodium falciparum)

GAPDH [cytosol] (Rattus norvegicus)

GAPDH [cytosol] (Saccharomyces cerevisiae)

GAPDH [cytosol] (Schizosaccharomyces pombe)

GAPDH [cytosol] (Sus scrofa)

GAPDH [cytosol] (Xenopus tropicalis)

LOC106558132 [cytosol] (Canis familiaris)

Homologues of GAPDH [cytosol] (Caenorhabditis elegans)

Homologues of GAPDH [cytosol] (Canis familiaris)

Homologues of GAPDH [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002037.2, NP_001276674.1, NP_001276675.1, NP_001243728.1

ZINC - World Drugs

G3P_HUMAN

OpenTargets

ENSG00000111640

ENSEMBL

ENST00000396861, ENSP00000380070, ENST00000229239, ENST00000619601, ENSP00000229239, ENSP00000380067, ENSP00000380068, ENSP00000478864, ENST00000396859, ENST00000396858

ZINC - Substances

G3P_HUMAN

ZINC - Biogenic

G3P_HUMAN

ZINC target

P04406

PRO

P04406

GlyGen

P04406

PDB

4WNI, 6YNH, 1ZNQ, 6ADE, 6YNE, 6YNF, 8G13, 8G16, 8G17, 8P5F, 8G12, 8G14, 8G15, 8DNS, 6M61, 6YND, 6IQ6, 3GPD, 4WNC, 1U8F

ZINC - Metabolites

G3P_HUMAN

HPA

ENSG00000111640-GAPDH

Pharos - Targets

P04406

ZINC - Predictions - Purchasable

G3P_HUMAN

HMDB Protein

HMDBP00695

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.785	7
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.675	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	7
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.571	3
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.564	2
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.556	3
UniProt:O75344 FKBP6	2	FKBP6 [nucleoplasm] (R-HSA-912512) FKBP6 [cytosol] (R-HSA-5601923)	0.556	3
UniProt:P17612 PRKACA	4	PRKACA [cytosol] (R-HSA-57844) PRKACA [nucleoplasm] (R-HSA-111936) PRKACA [ciliary base] (R-HSA-5610402) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
UniProt:Q9UIJ7 AK3	1	AK3 [mitochondrial matrix] (R-HSA-1008241)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.556	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.553	2
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:P49841 GSK3B	4	GSK3B [cytosol] (R-HSA-2997551) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [nucleoplasm] (R-HSA-2022823) GSK3B del304-316 [cytosol] (R-HSA-5339682)	0.547	2
UniProt:P00558 PGK1	1	PGK1 [cytosol] (R-HSA-70483)	0.544	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q92696 RABGGTA	2	RABGGTA [plasma membrane] (R-HSA-6801086) RABGGTA [cytosol] (R-HSA-8870418)	0.527	2
UniProt:P35228 NOS2	3	NOS2 [peroxisomal matrix] (R-HSA-9033124) NOS2 [nucleoplasm] (R-HSA-9636250) NOS2 [cytosol] (R-HSA-202107)	0.499	8
UniProt:P00441 SOD1	5	2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [extracellular region] (R-HSA-350705)	0.499	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12

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