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MyrG2-BLK [plasma membrane]
Stable Identifier
R-HSA-9606871
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tyrosine-protein kinase Blk ecNumber2.7.10.2/ecNumber, BLK_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)
LYN,FYN,BLK [plasma membrane] (Homo sapiens)
MyrG2-BLK [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51451 BLK
Gene Names
BLK
Chain
initiator methionine:, chain:2-505
Reference Genes
BioGPS Gene:640 BLK
COSMIC (genes):BLK BLK
CTD Gene:640 BLK
dbSNP Gene:640 BLK
ENSEMBL:ENSG00000136573 BLK
ENSEMBL_homo_sapiens_GENE:ENSG00000136573.16 BLK
ENSEMBL_homo_sapiens_GENE:ENSG00000285369.3 BLK
HGNC:1057 BLK
KEGG Gene (Homo sapiens):640 BLK
Monarch:640 BLK
NCBI Gene:640 BLK
OMIM:191305 BLK
UCSC:P51451 BLK
Reference Transcript
RefSeq:NM_001715.2 BLK
Other Identifiers
11727346_a_at
11756075_x_at
17065750
206255_3p_at
206255_PM_at
206255_at
3085991
3086008
3086009
3086010
3086011
3086013
3086014
3086016
3086017
3086019
3086021
3086026
3086029
3086033
3086034
3086035
3086036
640
8144625
854_at
A_23_P31725
GE81061
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005102
GO:0005515
GO:0005524
GO:0005829
GO:0005886
GO:0006468
GO:0007169
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0023052
GO:0030154
GO:0031234
GO:0032024
GO:0032092
GO:0035556
GO:0036211
GO:0045087
GO:0050853
GO:0098542
GO:0140096
ILMN_1668277
S76617_at
TC08000087.hg
TC08001801.hg
g4502412_3p_s_at
Participates
as a member of
LYN,FYN,BLK [plasma membrane] (Homo sapiens)
Other forms of this molecule
BLK [cytosol]
Modified Residues
Name
N-myristoylglycine at 2
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
RefSeq
NP_001706.2
ZINC - World Drugs
BLK_HUMAN
Guide to Pharmacology - Targets
1940
OpenTargets
ENSG00000136573
ZINC - FDA approved
BLK_HUMAN
ZINC - Substances
BLK_HUMAN
ZINC target
P51451
ZINC - Biogenic
BLK_HUMAN
PRO
P51451
ZINC - Investigational
BLK_HUMAN
HPA
ENSG00000136573-BLK
GeneCards
P51451
Ensembl
ENSG00000136573
,
ENST00000259089
,
ENSP00000259089
Pharos - Targets
P51451
Orphanet
19048
ZINC - Predictions - Purchasable
BLK_HUMAN
HMDB Protein
HMDBP01438
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.83
9
UniProt:O43281 EFS
0.712
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.692
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.669
3
UniProt:Q8IZU3 SYCP3
1
SYCP3 [nucleoplasm]
(R-HSA-912329)
0.589
2
UniProt:O75031 HSF2B
0.556
3
UniProt:Q96N16 JKIP1
0.556
3
UniProt:P51114-2 FXR1
0.556
3
UniProt:Q96Q35-2 FLACC1
0.556
5
UniProt:Q9BWW4 SSBP3
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:O14796 SH2D1B
1
SH2D1B [cytosol]
(R-HSA-5685187)
0.556
3
UniProt:O43281-2 EFS
0.556
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:Q13322-4 GRB10
0.556
3
UniProt:P49023-2 PXN
0.556
3
UniProt:O95551 TDP2
1
TDP2 [nucleoplasm]
(R-HSA-5687253)
0.556
3
UniProt:P51116 FXR2
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
UniProt:Q96BR9 ZBT8A
0.556
3
UniProt:Q13239-3 Q132393
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:A0A0C4DGF1 A0A0C4DGF1
0.556
3
UniProt:Q8NDB2 BANK1
0.556
6
IntAct:EBI-10171584 80125
0.556
3
IntAct:EBI-22620261 CCSB ORF ID
0.556
3
UniProt:Q9UGK3 STAP2
2
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
STAP2 [cytosol]
(R-HSA-8848028)
0.556
3
UniProt:Q6NX45 ZNF774
1
ZNF774 [nucleoplasm]
(R-HSA-3110232)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.556
3
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.556
3
UniProt:O14543 SOCS3
1
SOCS3 [cytosol]
(R-HSA-873794)
0.556
3
UniProt:Q6NXT1 ANR54
0.527
2
UniProt:P12724 RNASE3
2
RNASE3 [azurophil granule lumen]
(R-HSA-6799158)
RNASE3 [extracellular region]
(R-HSA-6803115)
0.527
2
UniProt:P06576 ATP5F1B
6
ATP5F1B [mitochondrial matrix]
(R-HSA-164576)
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
0.527
2
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.527
2
UniProt:Q9NTX9 F217B
0.527
2
UniProt:P48047 ATP5PO
1
ATP5PO [mitochondrial inner membrane]
(R-HSA-164533)
0.527
2
UniProt:P24539 ATP5PB
1
ATP5PB [mitochondrial inner membrane]
(R-HSA-164537)
0.527
2
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.527
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.499
3
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