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NEDD4L [cytosol]
Stable Identifier
R-HSA-976003
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase NEDD4-like, NED4L_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HIV Infection (Homo sapiens)
HIV Life Cycle (Homo sapiens)
Late Phase of HIV Life Cycle (Homo sapiens)
Budding and maturation of HIV virion (Homo sapiens)
HIV Virion Budding (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Virion Budding Complex [plasma membrane] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7:NEDD4L complex translocates to the cytosol (Homo sapiens)
SMAD7:NEDD4L [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Stimuli-sensing channels (Homo sapiens)
RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels (Homo sapiens)
RAF1:SGK:TSC22D3:WPP [cytosol] (Homo sapiens)
WPP1/NEDD4L [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
WPP1/NEDD4L [cytosol] (Homo sapiens)
NEDD4L [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96PU5 NEDD4L
Gene Names
NEDD4L, KIAA0439, NEDL3
Chain
initiator methionine:, chain:2-975
Reference Genes
BioGPS Gene:23327 NEDD4L
COSMIC (genes):NEDD4L NEDD4L
CTD Gene:23327 NEDD4L
dbSNP Gene:23327 NEDD4L
ENSEMBL:ENSG00000049759 NEDD4L
ENSEMBL_homo_sapiens_GENE:ENSG00000049759.20 NEDD4L
HGNC:7728 NEDD4L
KEGG Gene (Homo sapiens):23327 NEDD4L
Monarch:23327 NEDD4L
NCBI Gene:23327 NEDD4L
OMIM:606384 NEDD4L
UCSC:Q96PU5 NEDD4L
Reference Transcript
RefSeq:NM_001144968.1 NEDD4L
RefSeq:NM_001243960.1 NEDD4L
RefSeq:NM_001144967.2 NEDD4L
RefSeq:NM_001144966.2 NEDD4L
RefSeq:NM_001144971.1 NEDD4L
RefSeq:NM_001144964.1 NEDD4L
RefSeq:NM_001144970.2 NEDD4L
RefSeq:NM_001144965.1 NEDD4L
RefSeq:XM_017025679.1 NEDD4L
RefSeq:NM_001144969.1 NEDD4L
RefSeq:NM_015277.5 NEDD4L
Other Identifiers
11722423_a_at
11722424_a_at
11722425_s_at
11741140_s_at
11741141_x_at
11741547_a_at
11758571_s_at
16852573
212445_PM_s_at
212445_s_at
212448_PM_at
212448_at
226974_PM_at
226974_at
23327
241396_PM_at
241396_at
3789948
3789949
3789950
3789951
3789952
3789953
3789968
3789978
3789990
3790002
3790007
3790012
3790022
3790023
3790024
3790028
3790041
3790042
3790043
3790046
3790047
3790048
3790049
3790050
3790052
3790055
3790056
3790058
3790059
3790061
3790064
3790070
3790073
3790074
3790076
3790080
3790082
3790085
3790088
3790089
3790096
3790099
3790100
3790103
3790104
3790105
3790106
3790107
3790108
3790109
3790110
3790111
3790157
3790158
3790160
39356_at
51287_at
67652_at
8021376
A_14_P110610
A_23_P27279
A_23_P387856
A_24_P108311
A_24_P782308
A_33_P3391005
GE53186
GO:0003012
GO:0003013
GO:0003254
GO:0003824
GO:0004842
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005771
GO:0005794
GO:0005829
GO:0005886
GO:0006511
GO:0006513
GO:0015459
GO:0016192
GO:0016567
GO:0016740
GO:0017080
GO:0019870
GO:0019871
GO:0030154
GO:0030163
GO:0031410
GO:0031647
GO:0034220
GO:0034765
GO:0036211
GO:0042391
GO:0043161
GO:0043226
GO:0044325
GO:0045732
GO:0048814
GO:0048856
GO:0055085
GO:0060306
GO:0061630
GO:0070062
GO:0070936
GO:0086005
GO:0098772
GO:0140096
GO:1901016
GO:1901017
GO:1901380
GO:1902305
GO:1902306
GO:1903861
GO:2000009
GO:2000650
GO:2001288
HMNXSV003057322
Hs.12017.1.S1_3p_a_at
Hs.12017.1.S2_3p_at
Hs.3731.0.S1_3p_at
ILMN_1733627
PH_hs_0023225
TC18000202.hg
TC18000730.hg
TC18000731.hg
Participates
as a component of
Virion Budding Complex [plasma membrane] (Homo sapiens)
Smad7:NEDD4L [cytosol] (Homo sapiens)
SMAD7:NEDD4L [cytosol] (Homo sapiens)
as an input of
Recruitment Of HIV Virion Budding Machinery (Homo sapiens)
as a member of
WPP1/NEDD4L [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
as an output of
NEDD4L ubiquitinates Smad7 and TGFBR1 (Homo sapiens)
Other forms of this molecule
NEDD4L [nucleoplasm]
Inferred To
pub1 [cytosol]
(Schizosaccharomyces pombe)
RSP5 [cytosol]
(Saccharomyces cerevisiae)
Homologues of NEDD4L [cytosol]
(Dictyostelium discoideum)
Homologues of NEDD4L [cytosol]
(Schizosaccharomyces pombe)
Nedd4 [cytosol]
(Drosophila melanogaster)
pub3 [cytosol]
(Schizosaccharomyces pombe)
Nedd4l [cytosol]
(Mus musculus)
Nedd4l [cytosol]
(Rattus norvegicus)
NEDD4L [cytosol]
(Bos taurus)
NEDD4L [cytosol]
(Caenorhabditis elegans)
NEDD4L [cytosol]
(Canis familiaris)
NEDD4L [cytosol]
(Dictyostelium discoideum)
NEDD4L [cytosol]
(Gallus gallus)
NEDD4L [cytosol]
(Plasmodium falciparum)
NEDD4L [cytosol]
(Sus scrofa)
pub2 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001138438.1
,
NP_001138437.1
,
NP_001138436.1
,
NP_001230889.1
,
NP_001138443.1
,
NP_001138442.1
,
NP_056092.2
,
NP_001138441.1
,
XP_016881168.1
,
NP_001138439.1
,
NP_001138440.1
OpenTargets
ENSG00000049759
GeneCards
Q96PU5
HPA
ENSG00000049759-NEDD4L
Ensembl
ENSP00000383199
,
ENSP00000389406
,
ENST00000674517
,
ENSP00000502003
,
ENST00000676226
,
ENSP00000348847
,
ENSP00000393395
,
ENSP00000411947
,
ENSP00000405440
,
ENSP00000502325
,
ENSP00000502688
,
ENSP00000350569
,
ENST00000256830
,
ENST00000456173
,
ENSP00000502428
,
ENST00000431212
,
ENSP00000468546
,
ENST00000435432
,
ENSP00000372301
,
ENSG00000049759
,
ENST00000586263
,
ENST00000456986
,
ENST00000356462
,
ENST00000357895
,
ENST00000400345
,
ENSP00000256830
,
ENSP00000501665
,
ENST00000382850
,
ENST00000675502
,
ENST00000675865
,
ENST00000675801
PRO
Q96PU5
Pharos - Targets
Q96PU5
Orphanet
24755
HMDB Protein
HMDBP02282
PDB
6ZBT
,
7NMZ
,
7LP1
,
2LAJ
,
7LP2
,
6ZC9
,
2LTY
,
7LP3
,
2NSQ
,
2MPT
,
3JW0
,
2ONI
,
7LP4
,
2LB2
,
5HPK
,
7LP5
,
3JVZ
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.758
5
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.745
5
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.727
6
UniProt:Q96B67 ARRD3
0.702
4
UniProt:Q9BZD6 TMG4
0.656
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
8
UniProt:Q15038 DAZP2
0.556
3
UniProt:Q13571 LAPM5
0.547
2
UniProt:Q15884 EREP1
0.547
4
UniProt:Q4VCS5 AMOT
0.527
2
UniProt:Q8N5I2 ARRD1
0.527
4
UniProt:Q8NCT1 ARRD4
0.527
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.483
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.471
2
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