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TOLLIP [extracellular region]
Stable Identifier
R-HSA-6800448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Toll-interacting protein, TOLIP_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
TOLLIP [extracellular region] (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
TOLLIP [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H0E2 TOLLIP
Gene Names
TOLLIP
Chain
initiator methionine:, chain:2-274
Reference Genes
BioGPS Gene:54472 TOLLIP
COSMIC (genes):TOLLIP TOLLIP
CTD Gene:54472 TOLLIP
dbSNP Gene:54472 TOLLIP
ENSEMBL:ENSG00000078902 TOLLIP
ENSEMBL_homo_sapiens_GENE:ENSG00000078902.16 TOLLIP
ENSEMBL_homo_sapiens_GENE:ENSG00000291426.1 TOLLIP
HGNC:16476 TOLLIP
KEGG Gene (Homo sapiens):54472 TOLLIP
Monarch:54472 TOLLIP
NCBI Gene:54472 TOLLIP
OMIM:606277 TOLLIP
UCSC:Q9H0E2 TOLLIP
Reference Transcript
RefSeq:NM_001318515.1 TOLLIP
RefSeq:NM_001318516.1 TOLLIP
RefSeq:NM_019009.3 TOLLIP
RefSeq:NM_001318512.1 TOLLIP
RefSeq:NM_001318514.1 TOLLIP
Other Identifiers
11722171_a_at
11722172_a_at
11755301_a_at
16734240
217930_PM_s_at
217930_s_at
222469_PM_s_at
222469_s_at
233881_PM_s_at
233881_s_at
3358740
3358741
3358743
3358744
3358745
3358746
3358747
3358748
3358754
3358755
3358756
3358760
3358761
3358767
3358771
45728_at
54472
7945620
91328_at
A_23_P75903
A_24_P287189
A_33_P3385101
GE55270
GE846858
GO:0002376
GO:0005150
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005764
GO:0005768
GO:0005769
GO:0005773
GO:0005829
GO:0005886
GO:0006511
GO:0006914
GO:0006954
GO:0007165
GO:0016310
GO:0016604
GO:0019897
GO:0019900
GO:0023052
GO:0030154
GO:0030163
GO:0030855
GO:0031410
GO:0031624
GO:0031625
GO:0032183
GO:0032991
GO:0033235
GO:0035325
GO:0035578
GO:0035580
GO:0036010
GO:0036211
GO:0043130
GO:0043226
GO:0045087
GO:0045321
GO:0048471
GO:0048856
GO:0060090
GO:0070062
GO:0070498
GO:0098542
HMNXSV003058436
Hs.25413.1.S1_3p_a_at
ILMN_1765523
PH_hs_0002235
TC11001258.hg
g12053176_3p_a_at
g9506854_3p_a_at
Participates
as a member of
Specific granule lumen proteins [extracellular region] (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Other forms of this molecule
TOLLIP [cytosol]
TOLLIP [azurophil granule lumen]
TOLLIP [specific granule lumen]
Inferred To
TOLLIP [extracellular region]
(Bos taurus)
TOLLIP [extracellular region]
(Canis familiaris)
TOLLIP [extracellular region]
(Gallus gallus)
TOLLIP [extracellular region]
(Sus scrofa)
Tollip [extracellular region]
(Mus musculus)
Tollip [extracellular region]
(Rattus norvegicus)
CUE5 [extracellular region]
(Saccharomyces cerevisiae)
tollip [extracellular region]
(Danio rerio)
tollip [extracellular region]
(Xenopus tropicalis)
tli-1 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001305444.1
,
NP_001305445.1
,
NP_001305443.1
,
NP_001305441.1
,
NP_061882.2
OpenTargets
ENSG00000078902
GeneCards
Q9H0E2
HPA
ENSG00000078902-TOLLIP
Ensembl
ENSP00000314733
,
ENST00000317204
,
ENST00000527886
,
ENSP00000434035
,
ENSG00000078902
PRO
Q9H0E2
Pharos - Targets
Q9H0E2
PDB
2N31
,
1WGL
Interactors (56)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60784 TOM1
3
TOM1 [azurophil granule membrane]
(R-HSA-6799348)
TOM1 [plasma membrane]
(R-HSA-6806274)
TOM1 [specific granule membrane]
(R-HSA-6800923)
0.851
8
UniProt:Q15038 DAZP2
0.841
11
UniProt:O75674 TM1L1
0.804
6
UniProt:Q9BQY4 RHXF2
0.8
6
UniProt:Q05048 CSTF1
1
CSTF1 [nucleoplasm]
(R-HSA-72001)
0.695
5
UniProt:Q93062 RBPMS
0.666
4
UniProt:Q96HA8 NTAQ1
0.666
4
UniProt:P54253 ATX1
0.666
7
UniProt:Q6ZVM7 TM1L2
0.659
4
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
5
UniProt:Q4VC12 MSS51
0.556
3
UniProt:Q6ZVM7-2 TOM1L2
0.556
7
UniProt:Q3LI64 KRTAP6-1
1
KRTAP6-1 [cytosol]
(R-HSA-6810298)
0.556
5
UniProt:Q86UA1 PRP39
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:Q96D03 DDT4L
0.556
3
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.556
3
UniProt:Q70EL1-9 USP54
0.556
3
UniProt:Q9NWB1-5 RBFOX1
0.556
3
UniProt:Q3SYF9 KRTAP19-7
1
KRTAP19-7 [cytosol]
(R-HSA-6810305)
0.556
3
UniProt:Q96NT3-2 GUCD1
0.556
3
UniProt:Q3LI76 KRTAP15-1
1
KRTAP15-1 [cytosol]
(R-HSA-6810304)
0.556
3
UniProt:P86480 PR20D
0.556
3
UniProt:P32502
1
GCD7 [cytosol]
(R-SCE-72519)
0.556
3
UniProt:Q8N5M4 TTC9C
0.556
3
UniProt:Q96E35 ZMY19
0.556
3
UniProt:Q92567-2 FAM168A
0.556
3
UniProt:O60784-2 TOM1
0.556
5
UniProt:Q14203-5 DCTN1
0.556
3
UniProt:Q16656-4 NRF1
0.556
3
UniProt:Q8IUC3 KRA71
0.556
3
UniProt:P35548 MSX2
1
MSX2 [nucleoplasm]
(R-HSA-9007760)
0.556
3
UniProt:Q9BSU1 PHAF1
0.556
5
UniProt:O75674-2 TOM1L1
0.556
5
UniProt:O75553 DAB1
2
DAB1 [cytosol]
(R-HSA-8855236)
p-Y198,220,232-DAB1 [cytosol]
(R-HSA-8855227)
0.556
3
UniProt:Q5BKX5-3 ACTMAP
0.556
3
UniProt:O60260-5 PRKN
0.556
3
UniProt:Q96B67 ARRD3
0.556
3
UniProt:Q14764 MVP
3
MVP [secretory granule lumen]
(R-HSA-6803290)
MVP [extracellular region]
(R-HSA-6806474)
MVP [ficolin-1-rich granule lumen]
(R-HSA-6803325)
0.556
3
UniProt:A8MTA8-2 CIMIP2B
0.556
3
UniProt:Q5VYS4 MEDAG
0.556
3
UniProt:Q3SY46 KRTAP13-3
1
KRTAP13-3 [cytosol]
(R-HSA-6810267)
0.556
5
UniProt:Q9H668 STN1
1
STN1 [nucleoplasm]
(R-HSA-9668821)
0.556
3
UniProt:Q9H305 CDIP1
0.556
3
IntAct:EBI-22404606 CCSB ORF ID
0.556
3
UniProt:Q9UHG0 DCDC2
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:P20618 PSMB1
7
PSMB1(1-28) [cytosol]
(R-HSA-9908143)
pro-PSMB1 [cytosol]
(R-HSA-9908139)
PSMB1 [secretory granule lumen]
(R-HSA-6803287)
PSMB1 [extracellular region]
(R-HSA-6806477)
PSMB1 [ficolin-1-rich granule lumen]
(R-HSA-6803340)
PSMB1 [nucleoplasm]
(R-HSA-174347)
PSMB1 [cytosol]
(R-HSA-68738)
0.556
3
UniProt:P37840 SNCA
5
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
Ub-SNCA [cytosol]
(R-HSA-5660754)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
SNCA [cytosol]
(R-HSA-5658500)
0.556
3
UniProt:A1E959 ODAM
1
ODAM [extracellular region]
(R-HSA-977149)
0.553
2
UniProt:Q96S55 WRIP1
0.499
2
UniProt:Q86TG7 PEG10
0.499
2
UniProt:Q86Y13 DZIP3
1
DZIP3 [cytosol]
(R-HSA-976002)
0.499
2
UniProt:O43187 IRAK2
6
IRAK2 [endosome membrane]
(R-HSA-975116)
p-IRAK2 [endosome membrane]
(R-HSA-975187)
IRAK2 [plasma membrane]
(R-HSA-937014)
IRAK2 [cytosol]
(R-HSA-772534)
p-IRAK2 [plasma membrane]
(R-HSA-936949)
p-IRAK2 [cytosol]
(R-HSA-446636)
0.499
2
UniProt:P19525 EIF2AK2
5
p-EIF2AK2 [nucleoplasm]
(R-HSA-9836332)
SUMO-EIF2AK2 [cytosol]
(R-HSA-9834829)
ISG15-EIF2AK2 [cytosol]
(R-HSA-9833968)
p-EIF2AK2 [cytosol]
(R-HSA-9833834)
EIF2AK2 [cytosol]
(R-HSA-168699)
0.499
2
UniProt:Q9H492 MAP1LC3A
3
MAP1LC3A [autophagosome membrane]
(R-HSA-5683640)
MAP1LC3A(1-121) [cytosol]
(R-HSA-5682681)
MAP1LC3A [cytosol]
(R-HSA-5205676)
0.463
3
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