Reactome | SUMO2 [nucleoplasm]

SUMO2 [nucleoplasm]

Stable Identifier

R-HSA-2984281

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Small ubiquitin-related modifier 2, SUMO2_HUMAN

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DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12383504	Molecular features of human ubiquitin-like SUMO genes and their encoded proteins Su, HL, Li, SS	Gene	2002
9556629	Characterization of a second member of the sentrin family of ubiquitin-like proteins Kamitani, T, Kito, K, Nguyen, HP, Fukuda-Kamitani, T, Yeh, ET	J. Biol. Chem.	1998

External Reference Information

External Reference

UniProt:P61956 SUMO2

Gene Names

SUMO2, SMT3B, SMT3H2

Chain

chain:1-93, propeptide:94-95

Reference Genes

BioGPS Gene:6613 SUMO2

COSMIC (genes):SUMO2 SUMO2

CTD Gene:6613 SUMO2

dbSNP Gene:6613 SUMO2

ENSEMBL:ENSG00000188612 SUMO2

HGNC:11125 SUMO2

KEGG Gene (Homo sapiens):6613 SUMO2

Monarch:6613 SUMO2

NCBI Gene:6613 SUMO2

OMIM:603042 SUMO2

UCSC:P61956 SUMO2

Reference Transcript

Other Identifiers

0001770040

11716369_x_at

11741526_x_at

11753750_x_at

16848755

208738_3p_x_at

208738_x_at

208739_x_at

211444_at

213881_3p_x_at

213881_x_at

3003031

3761609

3770624

3770625

3770633

3770634

3770635

3770636

3770637

3770638

3770641

3770642

3770643

4018870

4018872

41185_f_at

6613

8018315

8174636

8178322

A_23_P107048

A_23_P118435

A_23_P310295

A_24_P330691

GE79270

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006464

GO:0008150

GO:0009056

GO:0016605

GO:0016925

GO:0019899

GO:0031386

GO:0031625

GO:0032436

GO:0043226

GO:0044389

HMNXSV003005390

HMNXSV003007837

Hs.180139.0.S2_3p_a_at

Hs.180139.0.S2_3p_x_at

Hs.180139.1.S1_3p_a_at

Hs.180139.1.S1_3p_x_at

ILMN_1738150

ILMN_2333594

PH_hs_0036913

TC17001873.hg

X99585_at

g12803928_3p_at

g5566605_3p_x_at

Participates

as a member of

as an output of

SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)

as an input of

Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)

as a repeated unit of

polySUMO2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SUMO2(1-95) [nucleoplasm]

UBA2-G93-SUMO2 [nucleoplasm]

UBE2I-G93-SUMO2 [nucleoplasm]

MDC1-SUMO2 [nucleoplasm]

Inferred To

SUMO2 [nucleoplasm] (Bos taurus)

SUMO2 [nucleoplasm] (Canis familiaris)

SUMO2 [nucleoplasm] (Dictyostelium discoideum)

SUMO2 [nucleoplasm] (Gallus gallus)

SUMO2 [nucleoplasm] (Plasmodium falciparum)

SUMO2 [nucleoplasm] (Sus scrofa)

sumo2 [nucleoplasm] (Danio rerio)

sumo2 [nucleoplasm] (Xenopus tropicalis)

Sumo2 [nucleoplasm] (Mus musculus)

Sumo2 [nucleoplasm] (Rattus norvegicus)

smt3 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_008868.3, NP_001005849.1

Target Pathogen

5b354852be737e166372ebeb, 5b354852be737e166372e9d3

OpenTargets

ENSG00000188612

HPA

ENSG00000188612-SUMO2

GeneCards

P61956

Ensembl

ENSP00000405965, ENSG00000188612, ENST00000420826, ENSP00000400886, ENST00000314523

PRO

P61956

PDB

5D2M, 5GHC, 2AWT, 2D07, 2IO0, 1WM2, 2N9E, 2CKH, 4NPN, 1WM3, 3UIO, 5EQL, 2IO3, 1Z5Q, 2IYD, 4BKG, 2N1W, 6JXW, 1WZ0, 2RPQ, 6JXX, 3ZO5, 3UIN, 5GHB, 5ELU

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) SUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.75	6
UniProt:Q9P0U3 SENP1	2	SENP1 [nucleoplasm] (R-HSA-2984299) SENP1 [cytosol] (R-HSA-9715128)	0.743	6
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.719	5
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.718	6
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.668	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.592	4
UniProt:P63279 UBE2I	8	UBE2I [nuclear envelope] (R-HSA-4655408) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.59	7
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.589	2
UniProt:Q5W0Q7 USPL1			0.573	2
UniProt:Q6DRC5 USPL1			0.558	2
UniProt:Q13569 TDG	3	TDG [nucleoplasm] (R-HSA-65812) SUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) SUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718)	0.558	2
UniProt:P23497-2 SP100			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:O15060 ZBT39			0.556	3
UniProt:Q86T24 KAISO			0.556	3
UniProt:Q96IT1 ZNF496	1	ZNF496 [nucleoplasm] (R-HSA-1247860)	0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.553	2
UniProt:O88846	1	Rnf4 [cytosol] (R-RNO-975974)	0.544	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.544	3
UniProt:Q8N2W9 PIAS4	2	SUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415) PIAS4 [nucleoplasm] (R-HSA-2993789)	0.508	3
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.499	3

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