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SUMO2 [nucleoplasm]
Stable Identifier
R-HSA-2984281
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Small ubiquitin-related modifier 2, SUMO2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
Ub,SUMO,K63polyUb:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
Ub,SUMO,K63polyUb:XPC [nucleoplasm] (Homo sapiens)
SUMO1,2,3 [nucleoplasm] (Homo sapiens)
SUMO2 [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
SUMO1,2,3 [nucleoplasm] (Homo sapiens)
SUMO2 [nucleoplasm] (Homo sapiens)
SUMOylation of XPC (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
SUMO1,2,3 [nucleoplasm] (Homo sapiens)
SUMO2 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
Processing and activation of SUMO (Homo sapiens)
SUMO is conjugated to E1 (UBA2:SAE1) (Homo sapiens)
Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)
SUMO2 [nucleoplasm] (Homo sapiens)
SUMO is proteolytically processed (Homo sapiens)
SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)
SUMO2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12383504
Molecular features of human ubiquitin-like SUMO genes and their encoded proteins
Su, HL
,
Li, SS
Gene
2002
9556629
Characterization of a second member of the sentrin family of ubiquitin-like proteins
Kamitani, T
,
Kito, K
,
Nguyen, HP
,
Fukuda-Kamitani, T
,
Yeh, ET
J. Biol. Chem.
1998
External Reference Information
External Reference
UniProt:P61956 SUMO2
Gene Names
SUMO2, SMT3B, SMT3H2
Chain
chain:1-93, propeptide:94-95
Reference Genes
BioGPS Gene:6613 SUMO2
COSMIC (genes):SUMO2 SUMO2
CTD Gene:6613 SUMO2
dbSNP Gene:6613 SUMO2
ENSEMBL:ENSG00000188612 SUMO2
HGNC:11125 SUMO2
KEGG Gene (Homo sapiens):6613 SUMO2
Monarch:6613 SUMO2
NCBI Gene:6613 SUMO2
OMIM:603042 SUMO2
UCSC:P61956 SUMO2
Reference Transcript
RefSeq:NM_006937.3 SUMO2
RefSeq:NM_001005849.1 SUMO2
Other Identifiers
0001770040
11716369_x_at
11741526_x_at
11753750_x_at
16848755
208738_3p_x_at
208738_x_at
208739_x_at
211444_at
213881_3p_x_at
213881_x_at
3003031
3761609
3770624
3770625
3770633
3770634
3770635
3770636
3770637
3770638
3770641
3770642
3770643
4018870
4018872
41185_f_at
6613
8018315
8174636
8178322
A_23_P107048
A_23_P118435
A_23_P310295
A_24_P330691
GE79270
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006464
GO:0008150
GO:0009056
GO:0016605
GO:0016925
GO:0019899
GO:0031625
GO:0032436
GO:0043226
Hs.180139.0.S2_3p_a_at
Hs.180139.0.S2_3p_x_at
Hs.180139.1.S1_3p_a_at
Hs.180139.1.S1_3p_x_at
ILMN_1738150
ILMN_2333594
PH_hs_0036913
TC17001873.hg
X99585_at
g12803928_3p_at
g5566605_3p_x_at
Participant Of
hasMember
SUMO1,2,3 [nucleoplasm]
SUMO2,3 [nucleoplasm]
output
SENP1,2,5 proteolytically process SUMO2
input
Conjugation of SUMO2 to UBA2:SAE1
repeatedUnit
polySUMO2 [nucleoplasm]
Other forms of this molecule
SUMO2(1-95) [nucleoplasm]
UBA2-G93-SUMO2 [nucleoplasm]
UBE2I-G93-SUMO2 [nucleoplasm]
MDC1-SUMO2 [nucleoplasm]
Inferred To
Homologues of SUMO2 [nucleoplasm] (Xenopus tropicalis)
SUMO3 [nucleoplasm] (Gallus gallus)
SUMO3 [nucleoplasm] (Sus scrofa)
sumo3 [nucleoplasm] (Xenopus tropicalis)
SUMO2 [nucleoplasm] (Canis familiaris)
SUMO2 [nucleoplasm] (Plasmodium falciparum)
sumo2 [nucleoplasm] (Danio rerio)
sumo2 [nucleoplasm] (Xenopus tropicalis)
Sumo3 [nucleoplasm] (Rattus norvegicus)
Gm49325 [nucleoplasm] (Mus musculus)
smt3 [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_001005849.1
,
NP_008868.3
OpenTargets
ENSG00000188612
HPA
ENSG00000188612-SUMO2
GeneCards
P61956
Ensembl
ENSP00000400886
,
ENST00000420826
,
ENST00000314523
,
ENSP00000405965
,
ENSG00000188612
PRO
P61956
PDB
5EQL
,
5ELU
,
2IO0
,
2D07
,
3UIO
,
4BKG
,
1WZ0
,
2N1W
,
2AWT
,
2CKH
,
1WM2
,
2N9E
,
1WM3
,
5GHB
,
5GHC
,
2RPQ
,
2IO3
,
3ZO5
,
1Z5Q
,
4NPN
,
5D2M
,
2IYD
,
3UIN
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P0U3 SENP1
1
SENP1 [nucleoplasm]
(R-HSA-2984299)
0.743
6
UniProt:Q9HC62 SENP2
1
SENP2 [nucleoplasm]
(R-HSA-2984298)
0.719
5
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.718
6
UniProt:Q12873 CHD3
2
SUMO1-K1971-CHD3 [nucleoplasm]
(R-HSA-8956372)
CHD3 [nucleoplasm]
(R-HSA-4657012)
0.668
3
UniProt:P46060 RANGAP1
3
RANGAP1 [nuclear envelope]
(R-HSA-167661)
SUMO1-K524-RANGAP1 [nuclear envelope]
(R-HSA-3000416)
RANGAP1 [cytosol]
(R-HSA-376255)
0.656
4
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.592
4
UniProt:P63279 UBE2I
8
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
0.59
7
UniProt:P38398 BRCA1
5
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
BRCA1 [nucleoplasm]
(R-HSA-50949)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.589
2
UniProt:Q5W0Q7 USPL1
0.573
2
UniProt:Q6DRC5 USPL1
0.558
2
UniProt:P23497-2 SP100
0.556
3
UniProt:Q8IX15-3 HOMEZ
0.556
3
UniProt:O15060 ZBT39
0.556
3
UniProt:Q86T24 KAISO
0.556
3
UniProt:Q96IT1 ZNF496
1
ZNF496 [nucleoplasm]
(R-HSA-1247860)
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:P08670 VIM
11
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.553
2
UniProt:Q15047 SETDB1
1
SETDB1 [nucleoplasm]
(R-HSA-417136)
0.553
2
UniProt:P10242 MYB
1
MYB [nucleoplasm]
(R-HSA-992697)
0.544
3
UniProt:O88846
1
Rnf4 [cytosol]
(R-RNO-975974)
0.544
2
UniProt:Q8N2W9 PIAS4
2
SUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
PIAS4 [nucleoplasm]
(R-HSA-2993789)
0.508
3
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.499
3
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