Reactome | SUMO2 [nucleoplasm]

SUMO2 [nucleoplasm]

Stable Identifier

R-HSA-2984281

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Small ubiquitin-related modifier 2, SUMO2_HUMAN

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
9556629	Characterization of a second member of the sentrin family of ubiquitin-like proteins Kamitani, T, Yeh, ET, Fukuda-Kamitani, T, Nguyen, HP, Kito, K	J. Biol. Chem.	1998
12383504	Molecular features of human ubiquitin-like SUMO genes and their encoded proteins Su, HL, Li, SS	Gene	2002

External Reference Information

External Reference

UniProt:P61956 SUMO2

Gene Names

SUMO2, SMT3B, SMT3H2

Chain

chain:1-93, propeptide:94-95

Reference Genes

BioGPS Gene:6613 SUMO2

COSMIC (genes):SUMO2 SUMO2

CTD Gene:6613 SUMO2

dbSNP Gene:6613 SUMO2

ENSEMBL:ENSG00000188612 SUMO2

HGNC:11125 SUMO2

KEGG Gene (Homo sapiens):6613 SUMO2

Monarch:6613 SUMO2

NCBI Gene:6613 SUMO2

OMIM:603042 SUMO2

UCSC:P61956 SUMO2

Reference Transcript

Other Identifiers

0001770040

11716369_x_at

11741526_x_at

11753750_x_at

16848755

208738_3p_x_at

208738_x_at

208739_x_at

211444_at

213881_3p_x_at

213881_x_at

3003031

3761609

3770624

3770625

3770633

3770634

3770635

3770636

3770637

3770638

3770641

3770642

3770643

4018870

4018872

41185_f_at

6613

8018315

8174636

8178322

A_23_P107048

A_23_P118435

A_23_P310295

A_24_P330691

GE79270

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0006464

GO:0008150

GO:0009056

GO:0009058

GO:0016605

GO:0016925

GO:0019789

GO:0019899

GO:0031386

GO:0031625

GO:0032436

GO:0034641

GO:0043226

GO:0044389

GO:0045944

HMNXSV003005390

HMNXSV003007837

Hs.180139.0.S2_3p_a_at

Hs.180139.0.S2_3p_x_at

Hs.180139.1.S1_3p_a_at

Hs.180139.1.S1_3p_x_at

ILMN_1738150

ILMN_2333594

PH_hs_0036913

TC17001873.hg

X99585_at

g12803928_3p_at

g5566605_3p_x_at

Participates

as a member of

SUMO1,2,3 [nucleoplasm] (Homo sapiens)

as an output of

SENP1,2,5 proteolytically process SUMO2 (Homo sapiens)

as an input of

Conjugation of SUMO2 to UBA2:SAE1 (Homo sapiens)

Other forms of this molecule

SUMO2(1-95) [nucleoplasm]

UBA2-G93-SUMO2 [nucleoplasm]

UBE2I-G93-SUMO2 [nucleoplasm]

lysyl-G93-SUMOyl-K11-SUMO2 [nucleoplasm]

Inferred To

Sumo [nucleoplasm] (Drosophila melanogaster)

SUMO2 [nucleoplasm] (Bos taurus)

SUMO2 [nucleoplasm] (Canis familiaris)

SUMO2 [nucleoplasm] (Dictyostelium discoideum)

SUMO2 [nucleoplasm] (Gallus gallus)

SUMO2 [nucleoplasm] (Plasmodium falciparum)

SUMO2 [nucleoplasm] (Sus scrofa)

sumo2 [nucleoplasm] (Danio rerio)

sumo2 [nucleoplasm] (Xenopus tropicalis)

Sumo2 [nucleoplasm] (Mus musculus)

Sumo2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_008868.3, NP_001005849.1

OpenTargets

ENSG00000188612

HPA

ENSG00000188612-SUMO2

GeneCards

P61956

Ensembl

ENSP00000400886, ENST00000314523, ENSG00000188612, ENSP00000405965, ENST00000420826

PRO

P61956

Pharos - Targets

P61956

PDB

2AWT, 5EQL, 2IYD, 1WM3, 5D2M, 5GHC, 4NPN, 2N1W, 5GHB, 2RPQ, 2CKH, 3UIO, 2D07, 6JXW, 3UIN, 5ELU, 2N9E, 1WZ0, 2IO3, 1WM2, 4BKG, 3ZO5, 2IO0, 6JXX

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) monoSUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.75	6
UniProt:Q9P0U3 SENP1	2	SENP1 [cytosol] (R-HSA-9715128) SENP1 [nucleoplasm] (R-HSA-2984299)	0.743	6
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.719	5
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.718	6
UniProt:Q12873 CHD3	2	CHD3 [nucleoplasm] (R-HSA-4657012) monoSUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372)	0.668	3
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.592	4
UniProt:P63279 UBE2I	8	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [cytosol] (R-HSA-4655342) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) UBE2I [nucleoplasm] (R-HSA-912481) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619)	0.59	7
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.589	2
UniProt:Q5W0Q7 USPL1			0.573	2
UniProt:Q6DRC5 USPL1			0.558	2
UniProt:Q13569 TDG	3	polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) TDG [nucleoplasm] (R-HSA-65812) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718)	0.558	2
UniProt:P23497-2 SP100			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:O15060 ZBT39			0.556	3
UniProt:Q86T24 KAISO			0.556	3
UniProt:Q96IT1 ZNF496	1	ZNF496 [nucleoplasm] (R-HSA-1247860)	0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.553	2
UniProt:O88846	1	Rnf4 [cytosol] (R-RNO-975974)	0.544	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.544	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.508	3
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.499	3

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