Reactome | SUMO2 [nucleoplasm]

SUMO2 [nucleoplasm]

Stable Identifier

R-HSA-2984281

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Small ubiquitin-related modifier 2, SUMO2_HUMAN

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- Nucleotide Excision Repair (Homo sapiens)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
    - Formation of Incision Complex in GG-NER (Homo sapiens)
      - RNF111 ubiquitinates SUMOylated XPC (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO,K63polyUb:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)
      - SUMOylation of XPC (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)
        
        Ub,SUMO:XPC [nucleoplasm] (Homo sapiens)
        
        SUMO1,2,3 [nucleoplasm] (Homo sapiens)
        
        SUMO2 [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12383504	Molecular features of human ubiquitin-like SUMO genes and their encoded proteins Su, HL, Li, SS	Gene	2002
9556629	Characterization of a second member of the sentrin family of ubiquitin-like proteins Kamitani, T, Kito, K, Nguyen, HP, Fukuda-Kamitani, T, Yeh, ET	J. Biol. Chem.	1998

External Reference Information

External Reference

UniProt:P61956 SUMO2

Gene Names

SUMO2, SMT3B, SMT3H2

Chain

chain:1-93, propeptide:94-95

Reference Genes

BioGPS Gene:6613 SUMO2

COSMIC (genes):SUMO2 SUMO2

CTD Gene:6613 SUMO2

dbSNP Gene:6613 SUMO2

ENSEMBL:ENSG00000188612 SUMO2

HGNC:11125 SUMO2

KEGG Gene (Homo sapiens):6613 SUMO2

Monarch:6613 SUMO2

NCBI Gene:6613 SUMO2

OMIM:603042 SUMO2

UCSC:P61956 SUMO2

Reference Transcript

Other Identifiers

0001770040

11716369_x_at

11741526_x_at

11753750_x_at

16848755

1WM2

1WM3

1WZ0

1Z5Q

208738_3p_x_at

208738_x_at

208739_x_at

211444_at

213881_3p_x_at

213881_x_at

2AWT

2CKH

2D07

2IO0

2IO3

2IYD

2N1W

2N9E

2RPQ

3003031

37314

3761609

3770624

3770625

3770633

3770634

3770635

3770636

3770637

3770638

3770641

3770642

3770643

3UIN

3UIO

3ZO5

4018870

4018872

41185_f_at

42123

48064

4BKG

4NPN

5D2M

5ELU

5EQL

5GHB

5GHC

6613

8018315

8174636

8178322

A0A024R8S3

A_23_P107048

A_23_P118435

A_23_P310295

A_24_P330691

AAD45399

AAH08450

AAH16775

AAH22340

AAH62713

AAH68465

AAH70159

AAH71645

AAH71646

AAI07854

AC022211

AK311837

BAG34779

BC008450

BC016775

BC022340

BC062713

BC068465

BC070159

BC071645

BC071646

BC107853

BF978876

CAA67897

CAB037314

CCDS45773

CCDS45774

CH471099

EAW89249

EAW89250

ENSG00000188612

ENSP00000400886

ENSP00000405965

ENST00000314523

ENST00000314523.7

ENST00000420826

ENST00000420826.6

EntrezGene:6613

EntrezGene:SUMO2

g12803928_3p_at

g5566605_3p_x_at

GE79270

GO:0001222

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0006464

GO:0008134

GO:0008150

GO:0009056

GO:0016605

GO:0016925

GO:0019899

GO:0031625

GO:0032436

GO:0043226

HGNC:11125

HPA042123

HPA048064

Hs.180139.0.S2_3p_a_at

Hs.180139.0.S2_3p_x_at

Hs.180139.1.S1_3p_a_at

Hs.180139.1.S1_3p_x_at

ILMN_1738150

ILMN_2333594

IPR000626

IPR022617

IPR029071

J3KRH1

L76416

MIM:603042

NM_001005849

NM_006937

NP_001005849

NP_008868

PF11976

PH_hs_0036913

SM00213

SUMO2

SUMO2-201

SUMO2-202

TC17001873.hg

UPI0000004177

UPI00001E69E0

X99585

X99585_at

Participant Of

hasMember

output

SENP1,2,5 proteolytically process SUMO2

input

Conjugation of SUMO2 to UBA2:SAE1

repeatedUnit

polySUMO2 [nucleoplasm]

Other forms of this molecule

SUMO2(1-95) [nucleoplasm]

UBA2-G93-SUMO2 [nucleoplasm]

UBE2I-G93-SUMO2 [nucleoplasm]

MDC1-SUMO2 [nucleoplasm]

Inferred To

SUMO2 [nucleoplasm] (Canis familiaris)

SUMO2 [nucleoplasm] (Dictyostelium discoideum)

SUMO2 [nucleoplasm] (Sus scrofa)

Sumo3 [nucleoplasm] (Rattus norvegicus)

Sumo2 [nucleoplasm] (Mus musculus)

smt3 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_008868.3, NP_001005849.1

Target Pathogen

5b354852be737e166372e9d3, 5b354852be737e166372ebeb

OpenTargets

ENSG00000188612

HPA

ENSG00000188612-SUMO2

GeneCards

P61956

Ensembl

ENSP00000400886, ENSG00000188612, ENST00000420826, ENSP00000405965, ENST00000314523

PRO

P61956

PDB

2IYD, 2N1W, 2RPQ, 5GHB, 5ELU, 2IO3, 2AWT, 1WM3, 1WM2, 5EQL, 2CKH, 3ZO5, 4BKG, 2IO0, 4NPN, 2N9E, 5D2M, 1WZ0, 2D07, 5GHC, 3UIN, 3UIO, 1Z5Q

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9P0U3 SENP1	1	SENP1 [nucleoplasm] (R-HSA-2984299)	0.743	6
UniProt:Q9HC62 SENP2	1	SENP2 [nucleoplasm] (R-HSA-2984298)	0.719	5
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.718	6
UniProt:Q12873 CHD3	2	SUMO1-K1971-CHD3 [nucleoplasm] (R-HSA-8956372) CHD3 [nucleoplasm] (R-HSA-4657012)	0.668	3
UniProt:P46060 RANGAP1	3	RANGAP1 [nuclear envelope] (R-HSA-167661) SUMO1-K524-RANGAP1 [nuclear envelope] (R-HSA-3000416) RANGAP1 [cytosol] (R-HSA-376255)	0.656	4
UniProt:Q8IZL8 PELP1	1	PELP1 [nucleoplasm] (R-HSA-3826531)	0.592	4
UniProt:P63279 UBE2I	8	SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) SUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) UBE2I [cytosol] (R-HSA-4655342) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617)	0.59	7
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.589	2
UniProt:Q5W0Q7 USPL1			0.573	2
UniProt:Q6DRC5 USPL1			0.558	2
UniProt:P23497-2 SP100			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:O15060 ZBT39			0.556	3
UniProt:Q86T24 KAISO			0.556	3
UniProt:Q96IT1 ZNF496	1	ZNF496 [nucleoplasm] (R-HSA-1247860)	0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:P08670 VIM	11	VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.544	3
UniProt:O88846	2	Rnf4 [nucleoplasm] (R-RNO-5684076) Rnf4 [cytosol] (R-RNO-975974)	0.544	2
UniProt:Q8N2W9 PIAS4	2	SUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415) PIAS4 [nucleoplasm] (R-HSA-2993789)	0.508	3
UniProt:Q92844 TANK	2	TANK [cytosol] (R-HSA-933407) K63polyUb-TANK [cytosol] (R-HSA-5362480)	0.499	3