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HSPA1L [cytosol]
Stable Identifier
R-HSA-3371410
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Heat shock 70 kDa protein 1-like, Heat shock 70 kDa protein 1L, HSP70-Hom
Locations in the PathwayBrowser
Expand all
Cellular responses to external stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
Regulation of HSF1-mediated heat shock response (Homo sapiens)
HSP110s exchange ATP for ADP on HSP70s:ADP (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA1L:ADP [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA1L:ATP [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol (Homo sapiens)
HSP70s:ADP [cytosol] (Homo sapiens)
HSPA1L:ADP [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA1L:ATP [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
Hikeshi binds HSP70s:ATP (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA1L:ATP [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA1L:ATP [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Homo sapiens)
Hikeshi:HSP70s:ATP [cytosol] (Homo sapiens)
HSP70s:ATP [cytosol] (Homo sapiens)
HSPA1L:ATP [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) (Homo sapiens)
ATP binding to HSP90 triggers conformation change (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
ATP hydrolysis by HSP70 (Homo sapiens)
HSP40:HSP70:ADP:nascent protein [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP40:HSP70:ATP:nascent protein [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein (Homo sapiens)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP70 binds to HSP40:nascent protein (Homo sapiens)
HSP40:HSP70:ATP:nascent protein [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP70:ATP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein (Homo sapiens)
HSP40:HSP70:ADP:nascent protein [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP90:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein (Homo sapiens)
HSP70:ATP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP90:ATP:FKBP4:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein (Homo sapiens)
HSP70:ATP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
HSP90:ATP:FKBP5:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP90:ATP:STIP1:HSP70:nascent protein [cytosol] (Homo sapiens)
HSP70:ADP [cytosol] (Homo sapiens)
HSP70 proteins [cytosol] (Homo sapiens)
HSPA1L [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34931 HSPA1L
Gene Names
HSPA1L
Chain
chain:1-641
Reference Genes
BioGPS Gene:3305 HSPA1L
COSMIC (genes):HSPA1L HSPA1L
CTD Gene:3305 HSPA1L
dbSNP Gene:3305 HSPA1L
ENSEMBL:ENSG00000204390 HSPA1L
ENSEMBL:ENSG00000206383 HSPA1L
ENSEMBL:ENSG00000234258 HSPA1L
ENSEMBL:ENSG00000236251 HSPA1L
HGNC:5234 HSPA1L
KEGG Gene (Homo sapiens):3305 HSPA1L
Monarch:3305 HSPA1L
NCBI Gene:3305 HSPA1L
OMIM:140559 HSPA1L
UCSC:P34931 HSPA1L
Reference Transcript
RefSeq:NM_005527.3 HSPA1L
Other Identifiers
0003990358
11727138_a_at
17017485
17026864
17029337
17032123
17039574
210189_at
2949451
2949452
2949453
2949454
2949455
2949456
2949457
3305
40656_at
8125134
8178650
8179848
A_23_P70547
GE57353
GE81523
GO:0000003
GO:0000166
GO:0002199
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0005886
GO:0006457
GO:0006605
GO:0006810
GO:0006950
GO:0006986
GO:0007005
GO:0007339
GO:0008150
GO:0008180
GO:0015031
GO:0016192
GO:0016887
GO:0019899
GO:0031072
GO:0031625
GO:0032991
GO:0034620
GO:0042026
GO:0043167
GO:0043226
GO:0044183
GO:0044297
GO:0051082
GO:0051085
GO:0051787
GO:0072562
GO:1900034
GO:1903955
ILMN_1654566
M59829_at
PH_hs_0004622
TC06001546.hg
TC6_apd_hap1000087.hg
TC6_cox_hap2000173.hg
TC6_dbb_hap3000162.hg
TC6_qbl_hap6000163.hg
g3461865_3p_at
Participant Of
hasCandidate
HSP70 proteins [cytosol]
hasComponent
HSPA1L:ADP [cytosol]
HSPA1L:ATP [cytosol]
Other forms of this molecule
HSPA1L [nucleoplasm]
Inferred To
Hsc70-2 [cytosol] (Drosophila melanogaster)
hspE-2 [cytosol] (Dictyostelium discoideum)
hspB [cytosol] (Dictyostelium discoideum)
Homologues of HSPA1L [cytosol] (Dictyostelium discoideum)
Homologues of HSPA1L [cytosol] (Saccharomyces cerevisiae)
Homologues of HSPA1L [cytosol] (Schizosaccharomyces pombe)
Homologues of HSPA1L [cytosol] (Xenopus tropicalis)
ssa2 [cytosol] (Schizosaccharomyces pombe)
SSA3 [cytosol] (Saccharomyces cerevisiae)
SSA4 [cytosol] (Saccharomyces cerevisiae)
ssa1 [cytosol] (Schizosaccharomyces pombe)
hsp70 [cytosol] (Xenopus tropicalis)
SSA1 [cytosol] (Saccharomyces cerevisiae)
Hspa1l [cytosol] (Mus musculus)
Hspa1l [cytosol] (Rattus norvegicus)
HSPA1L [cytosol] (Bos taurus)
HSPA1L [cytosol] (Canis familiaris)
HSPA1L [cytosol] (Dictyostelium discoideum)
HSPA1L [cytosol] (Plasmodium falciparum)
SSA2 [cytosol] (Saccharomyces cerevisiae)
hspa1b [cytosol] (Danio rerio)
hspa1b [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_005518.3
OpenTargets
ENSG00000204390
HPA
ENSG00000204390-HSPA1L
GeneCards
P34931
Ensembl
ENSG00000206383
,
ENST00000417601
,
ENSP00000364805
,
ENST00000456772
,
ENST00000383390
,
ENSP00000408347
,
ENST00000375654
,
ENSP00000372881
,
ENSP00000396486
,
ENSG00000204390
,
ENSG00000236251
,
ENSG00000234258
PRO
P34931
PDB
3GDQ
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95429 BAG4
3
BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853156)
BAG4 [cytosol]
(R-HSA-5212670)
BAG4(1-126):FGFR1(208-822) fusion [plasma membrane]
(R-HSA-8853157)
0.666
4
UniProt:Q13233 MAP3K1
2
p-T1400,T1412-MAP3K1 [cytosol]
(R-HSA-2685607)
MAP3K1 [cytosol]
(R-HSA-166866)
0.589
2
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.589
2
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.589
2
UniProt:P19838 NFKB1
8
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.564
3
UniProt:Q00613 HSF1
11
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
HSF1 [cytosol]
(R-HSA-3371452)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
0.508
2
UniProt:P11142 HSPA8
10
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.462
2
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