Reactome | HSPA1L [cytosol]

HSPA1L [cytosol]

Stable Identifier

R-HSA-3371410

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Heat shock 70 kDa protein 1-like, Heat shock 70 kDa protein 1L, HSP70-Hom

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P34931 HSPA1L

Gene Names

HSPA1L

Chain

chain:1-641

Reference Genes

BioGPS Gene:3305 HSPA1L

COSMIC (genes):HSPA1L HSPA1L

CTD Gene:3305 HSPA1L

dbSNP Gene:3305 HSPA1L

ENSEMBL:ENSG00000204390 HSPA1L

ENSEMBL:ENSG00000206383 HSPA1L

ENSEMBL:ENSG00000234258 HSPA1L

ENSEMBL:ENSG00000236251 HSPA1L

HGNC:5234 HSPA1L

KEGG Gene (Homo sapiens):3305 HSPA1L

Monarch:3305 HSPA1L

NCBI Gene:3305 HSPA1L

OMIM:140559 HSPA1L

UCSC:P34931 HSPA1L

Reference Transcript

RefSeq:NM_005527.3 HSPA1L

Other Identifiers

0003990358

11727138_a_at

17017485

17026864

17029337

17032123

17039574

210189_at

2949451

2949452

2949453

2949454

2949455

2949456

2949457

3305

40656_at

8125134

8178650

8179848

A_23_P70547

GE57353

GE81523

GO:0000003

GO:0000166

GO:0002199

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0006457

GO:0006605

GO:0006810

GO:0006950

GO:0006986

GO:0007005

GO:0007339

GO:0008150

GO:0008180

GO:0015031

GO:0016192

GO:0016887

GO:0019899

GO:0031072

GO:0031625

GO:0032991

GO:0034620

GO:0042026

GO:0043167

GO:0043226

GO:0044183

GO:0044297

GO:0051082

GO:0051085

GO:0051787

GO:0072562

GO:1900034

GO:1903955

ILMN_1654566

M59829_at

PH_hs_0004622

TC06001546.hg

TC6_apd_hap1000087.hg

TC6_cox_hap2000173.hg

TC6_dbb_hap3000162.hg

TC6_qbl_hap6000163.hg

g3461865_3p_at

Participant Of

hasCandidate

HSP70 proteins [cytosol]

hasComponent

Other forms of this molecule

HSPA1L [nucleoplasm]

Inferred To

Hsc70-2 [cytosol] (Drosophila melanogaster)

hspE-2 [cytosol] (Dictyostelium discoideum)

hspB [cytosol] (Dictyostelium discoideum)

Homologues of HSPA1L [cytosol] (Dictyostelium discoideum)

Homologues of HSPA1L [cytosol] (Saccharomyces cerevisiae)

Homologues of HSPA1L [cytosol] (Schizosaccharomyces pombe)

Homologues of HSPA1L [cytosol] (Xenopus tropicalis)

ssa2 [cytosol] (Schizosaccharomyces pombe)

SSA3 [cytosol] (Saccharomyces cerevisiae)

SSA4 [cytosol] (Saccharomyces cerevisiae)

ssa1 [cytosol] (Schizosaccharomyces pombe)

hsp70 [cytosol] (Xenopus tropicalis)

SSA1 [cytosol] (Saccharomyces cerevisiae)

Hspa1l [cytosol] (Mus musculus)

Hspa1l [cytosol] (Rattus norvegicus)

HSPA1L [cytosol] (Bos taurus)

HSPA1L [cytosol] (Canis familiaris)

HSPA1L [cytosol] (Dictyostelium discoideum)

HSPA1L [cytosol] (Plasmodium falciparum)

SSA2 [cytosol] (Saccharomyces cerevisiae)

hspa1b [cytosol] (Danio rerio)

hspa1b [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005518.3

OpenTargets

ENSG00000204390

GeneCards

P34931

HPA

ENSG00000204390-HSPA1L

Ensembl

ENSG00000206383, ENSP00000364805, ENST00000417601, ENST00000375654, ENSG00000236251, ENST00000456772, ENSP00000372881, ENSP00000396486, ENSG00000204390, ENSG00000234258, ENSP00000408347, ENST00000383390

PRO

P34931

PDB

3GDQ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95429 BAG4	3	BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.666	4
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.589	2
UniProt:Q13233 MAP3K1	2	p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607) MAP3K1 [cytosol] (R-HSA-166866)	0.589	2
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.589	2
UniProt:P19838 NFKB1	8	NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.564	3
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.508	2
UniProt:P11142 HSPA8	10	HSPA8 [secretory granule lumen] (R-HSA-6801530) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.462	2

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