Reactome | HSPA1L [cytosol]

HSPA1L [cytosol]

Stable Identifier

R-HSA-3371410

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Heat shock 70 kDa protein 1-like, Heat shock 70 kDa protein 1L, HSP70-Hom

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P34931 HSPA1L

Gene Names

HSPA1L

Chain

chain:1-641

Reference Genes

BioGPS Gene:3305 HSPA1L

COSMIC (genes):HSPA1L HSPA1L

CTD Gene:3305 HSPA1L

dbSNP Gene:3305 HSPA1L

ENSEMBL:ENSG00000204390 HSPA1L

ENSEMBL:ENSG00000206383 HSPA1L

ENSEMBL:ENSG00000234258 HSPA1L

ENSEMBL:ENSG00000236251 HSPA1L

HGNC:5234 HSPA1L

KEGG Gene (Homo sapiens):3305 HSPA1L

Monarch:3305 HSPA1L

NCBI Gene:3305 HSPA1L

OMIM:140559 HSPA1L

UCSC:P34931 HSPA1L

Reference Transcript

RefSeq:NM_005527.3 HSPA1L

Other Identifiers

0003990358

11727138_a_at

17017485

17026864

17029337

17032123

17039574

210189_at

2949451

2949452

2949453

2949454

2949455

2949456

2949457

3305

3GDQ

40656_at

43285

52504

8125134

8178650

8179848

A0A1U9X7W7

A0A1U9X7X9

A_23_P70547

AAA63228

AAD21817

AAH34483

ABC88476

ADO22199

AF134726

AL662834

AL671762

AL929592

AQY76885

AQY76886

AQY76888

AQY76889

AQY76890

BA000025

BAA32521

BAB63301

BC034483

CCDS34413

CR388202

D85730

DQ383515

ENSG00000204390

ENSG00000206383

ENSG00000234258

ENSG00000236251

ENSP00000364805

ENSP00000372881

ENSP00000396486

ENSP00000408347

ENST00000375654

ENST00000375654.4

ENST00000383390

ENST00000417601

ENST00000456772

EntrezGene:3305

EntrezGene:HSPA1L

g3461865_3p_at

GE57353

GE81523

GO:0000003

GO:0000166

GO:0002199

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0006457

GO:0006605

GO:0006810

GO:0006950

GO:0006986

GO:0007005

GO:0007339

GO:0008150

GO:0008180

GO:0015031

GO:0016192

GO:0016887

GO:0019899

GO:0031072

GO:0031625

GO:0032991

GO:0034605

GO:0034620

GO:0042026

GO:0042623

GO:0043167

GO:0043226

GO:0044183

GO:0044297

GO:0051082

GO:0051085

GO:0051787

GO:0072562

GO:1900034

GO:1903955

GQ891337

HGNC:5234

HPA043285

HPA052504

HSPA1L

HSPA1L-201

HSPA1L-202

HSPA1L-204

HSPA1L-205

ILMN_1654566

IPR013126

IPR018181

IPR029047

IPR029048

KY500398

KY500399

KY500401

KY500402

KY500403

M59829

M59829_at

MIM:140559

NM_005527

NP_005518

PF00012

PH_hs_0004622

PR00301

Q53FA3

TC06001546.hg

TC6_apd_hap1000087.hg

TC6_cox_hap2000173.hg

TC6_dbb_hap3000162.hg

TC6_qbl_hap6000163.hg

UPI000012CC97

UPI000013D087

Participant Of

hasCandidate

HSP70 proteins [cytosol]

hasComponent

Other forms of this molecule

HSPA1L [nucleoplasm]

Inferred To

Homologues of HSPA1L [cytosol] (Danio rerio)

Homologues of HSPA1L [cytosol] (Dictyostelium discoideum)

Homologues of HSPA1L [cytosol] (Drosophila melanogaster)

Homologues of HSPA1L [cytosol] (Saccharomyces cerevisiae)

Homologues of HSPA1L [cytosol] (Schizosaccharomyces pombe)

HSPA1L [cytosol] (Bos taurus)

HSPA1L [cytosol] (Caenorhabditis elegans)

HSPA1L [cytosol] (Canis familiaris)

HSPA1L [cytosol] (Danio rerio)

HSPA1L [cytosol] (Dictyostelium discoideum)

HSPA1L [cytosol] (Drosophila melanogaster)

HSPA1L [cytosol] (Mus musculus)

HSPA1L [cytosol] (Plasmodium falciparum)

HSPA1L [cytosol] (Rattus norvegicus)

HSPA1L [cytosol] (Saccharomyces cerevisiae)

HSPA1L [cytosol] (Schizosaccharomyces pombe)

HSPA1L [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_005518.3

OpenTargets

ENSG00000204390

GeneCards

P34931

PRO

P34931

PDB

3GDQ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95429 BAG4	3	BAG4(1-126):p-8Y FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126):FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.621	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.589	2
UniProt:Q13233 MAP3K1	2	p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607) MAP3K1 [cytosol] (R-HSA-166866)	0.589	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.589	2
UniProt:P19838 NFKB1	8	p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.564	3
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.508	2
UniProt:P11142 HSPA8	10	HSPA8 [plasma membrane] (R-HSA-936508) Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.462	2